Steroid Withdrawal in Simultaneous Pancreas-Kidney Transplantation: A 7-Year Report

Transplantation Proceedings

Volumn 41, Issue 3, 2009, Pages 909-912

  Malheiro, J ^a   Martins, L ^a   Fonseca, I ^a   Gomes, A M ^b   Santos, J ^a   Dias, L ^a   Dores, J ^a   Oliveira, F ^a   Seca, R ^a   Almeida, R ^a   Henriques, A ^a   Cabrita, A ^a   Teixeira, M ^a  

^a HOSPITAL DE SANTO ANTÓNIO   (Portugal)

^b Centro Hospitalar Vila Nova Gaia/Espinho   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; CORTICOSTEROID; CREATININE; HEMOGLOBIN A1C; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METHYLPREDNISOLONE; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OKT 3; PREDNISOLONE; RAPAMYCIN; TACROLIMUS; THYMOCYTE ANTIBODY;

ADULT; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; GASTROINTESTINAL DISEASE; GRAFT VERSUS HOST REACTION; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; KIDNEY PANCREAS TRANSPLANTATION; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; NEPHRITIS; OBESITY; PLASMAPHERESIS; PREVALENCE; PRIORITY JOURNAL; THROMBOTIC THROMBOCYTOPENIC PURPURA; TREATMENT OUTCOME;

ADRENAL CORTEX HORMONES; CREATININE; DIABETES MELLITUS; DIABETIC NEPHROPATHIES; DRUG ADMINISTRATION SCHEDULE; FOLLOW-UP STUDIES; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; LIPIDS; PANCREAS TRANSPLANTATION; SURVIVAL ANALYSIS; SURVIVORS; TIME FACTORS;

EID: 64649090379     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2009.03.036     Document Type: Article

References (24)

1. Strata R.J. Review of immunosuppressive usage in pancreas transplantation. Clin Transplant 13 (1999) 1
2. Danovitch G.M. Immunosuppressive medications for renal transplantation: a multiple choice question. Kidney Int 59 (2001) 388
3. Tanchanco V., Krishnamurthi C., Winans A., et al. Beneficial outcomes of a steroid-free regimen with thymoglobulin induction in pancreas-kidney transplantation. Transplant Proc 40 (2008) 1551
4. Malaise J., Kuypers D.R.J., Claes P., et al. Immunosuppressive drugs after simultaneous pancreas-kidney transplantation. Transplant Proc 37 (2005) 2840
5. Grotz W.H., Mundinger F.A., Gugel B., et al. Bone fracture and osteodensitometry with dual energy X-ray absorptiometry in kidney transplant recipients. Transplantation 58 (1994) 912
6. Veenstra D.L., Best J.H., Hornberger J., et al. Incidence and long-term cost of steroid-related side effects after renal transplantation. Am J Kidney Dis 33 (1999) 829
7. Miozzari M., and Ambuhl P.M. Steroid withdrawal after long-term medication for immunosuppressive therapy in renal transplant patients: adrenal response and clinical implications. Nephrol Dial Transplant 19 (2004) 2615
8. Cantarovich D., Paineau J., Karam G., et al. Definitive corticosteroid withdrawal following simultaneous pancreas and kidney transplantation. Transplant Proc 23 (1991) 1583
9. Pascual J., Quereda C., Zamora J., et al. Steroid withdrawal in renal transplant patients on triple therapy with a calcineurin inhibitor and mycophenolate mofetil: a meta-analysis of randomized, controlled trials. Transplantation 78 (2004) 1548
10. Gjertson D.W., Terasaki P.I., and Cecka J.M. Impact analysis: a method for evaluating the impact of factors in clinical renal transplantation. Clin Transplant (1998) 437
11. Hricik D.E. Steroid-free immunosuppression in kidney transplantation: an editorial review. Am J Transplant 2 (2002) 19
12. Ratcliffe P.J., Dudley C.R., Higgins R.M., et al. Randomised controlled trail of steroid withdrawal in renal transplant recipients receiving triple immunosuppression. Lancet 348 (1996) 643
13. Smak Gregoor P.J., de Sevaux R.G., Ligtenberg G., et al. Withdrawal of cyclosporine or predisone six months after kidney transplantation in patients on triple drug therapy: a randomized, prospective, multicenter study. J Am Soc Nephrol 13 (2002) 1365
14. Mahalati K., and Kahan B.D. A pilot study of steroid withdrawal from kidney transplant recipients on sirolimus-cyclosporine a combination therapy. Transplant Proc 33 (2001) 3232
15. Citterio F., Rigotti P., Scat M.C., et al. Steroid withdrawal in renal transplant patients treated with tacrolimus. Am J Transplant 2 (2002) 172
16. Aoun M., Eschewege P., Hamoudi Y., et al. Very early steroid withdrawal in simultaneous pancreas-kidney transplants. Nephrol Dial Transplant 22 (2007) 899
17. Freise C.E., Kang S.M., Feng S., et al. Excellent short-term results with steroid-free maintenance immunosuppression in low-risk simultaneous pancreas-kidney transplantation. Arch Surg 138 (2003) 1121
18. Jaber J.J., Feustel P.J., Elbahloul O., et al. Early steroid withdrawal therapy in renal transplant recipients: a steroid-free sirolimus and cellcept-based calcineurin inhibitor-minimization protocol. Clin Transplant 21 (2007) 101
19. Kaufman D.B., Leventhal J.R., Koffron A.J., et al. A prospective study of rapid corticosteroid elimination in simultaneous pancreas-kidney transplantation. Transplantation 73 (2002) 169
20. Cantarovich D., Karam G., Hourmant M., et al. Steroid avoidance versus steroid withdrawal after simultaneous pancreas-kidney transplantation. Am J Transplantation 5 (2005) 1332
21. Malaise J., Nakache R., Kahl A., et al. Corticosteroid withdrawal in simultaneous pancreas-kidney transplantation: a 3-year report. Transplant Proc 37 (2005) 2853
22. Jordan M.L., Chakrabarti P., Luke P., et al. Results of pancreas transplantation after steroid withdrawal under tacrolimus immunosuppression. Transplantation 69 (2000) 265
23. Opelz G. Collaborative transplant study. CTS Newsletter 4 (2000) 3
24. Morrisett J.D., Abdel-Fattah G., Hoogeveen R., et al. Effects of sirolimus on plasma lipids, lipoprotein levels, and fatty acid metabolism in renal transplant patients. J Lipid Res 43 (2002) 1170