Single nucleotide variants of the TGACTCA motif modulate energetics and orientation of binding of the jun-fos heterodimeric transcription factor

Biochemistry

Volumn 48, Issue 9, 2009, Pages 1975-1983

  Seldeen, Kenneth L ^a   McDonald, Caleb B ^a   Deegan, Brian J ^a   Farooq, Amjad ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3D ATOMIC MODELS; CELLULAR PROCESS; CIS-ELEMENTS; CRITICAL DETERMINANTS; CYTOKINES; DIFFERENTIAL REGULATIONS; DNA TRANSCRIPTIONS; ELECTROSTATIC INTERACTIONS; ENTROPIC CHANGES; EXTRACELLULAR; GENE PROMOTERS; GROWTH FACTORS; HETERODIMER; INTERMOLECULAR HYDROGEN BONDINGS; ISOTHERMAL TITRATION CALORIMETRIES; PREFERRED ORIENTATIONS; PROTEIN-DNA INTERACTIONS; SINGLE NUCLEOTIDE POLYMORPHISMS; SINGLE NUCLEOTIDES; TERMINAL LINKS;

DNA; FOOD ADDITIVES; GENES; HYDROGEN; HYDROGEN BONDS; NUCLEIC ACIDS; NUCLEOTIDES; THREE DIMENSIONAL; TRANSCRIPTION FACTORS;

TRANSCRIPTION;

HETERODIMER; PROTEIN FOS; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR JUN; UNCLASSIFIED DRUG;

ARTICLE; BASIC LEUCINE ZIPPER MOTIF; BINDING AFFINITY; ENERGY TRANSFER; ENTHALPY; ENTROPY; GENETIC VARIABILITY; HYDROGEN BOND; ISOTHERMAL TITRATION CALORIMETRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DNA INTERACTION; SINGLE NUCLEOTIDE POLYMORPHISM; THERMODYNAMICS;

AMINO ACID SEQUENCE; BASE SEQUENCE; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; BINDING SITES; BINDING, COMPETITIVE; CALORIMETRY; DNA; ENTROPY; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES; POINT MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; SEQUENCE HOMOLOGY, AMINO ACID; THERMODYNAMICS; TITRIMETRY;

EID: 64549151992     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi802068s     Document Type: Article

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