Expression of LGR7 in the primate corpus luteum implicates the corpus luteum as a relaxin target organ

Annals of the New York Academy of Sciences

Volumn 1160, Issue , 2009, Pages 147-151

  Maseelall, Priya B ^a   Seungdamrong, Aimee ^a   Weiss, Gerson ^a   Wojtczuk, Andrea S ^a   Donnelly, Robert ^a   Stouffer, Richard L ^b   Goldsmith, Laura T ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Corpus luteum; LGR7; Relaxin; Relaxin receptor; Rhesus monkey; RXFP1

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GONADORELIN ANTAGONIST; ITURELIX; LUTEINIZING HORMONE; MESSENGER RNA; PROTEIN LGR7; PROTEIN RXFP1; RELAXIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; CORPUS LUTEUM; FEMALE; LUTEAL PHASE; MACACA; MENSTRUAL CYCLE; NONHUMAN; NUCLEOTIDE SEQUENCE; PREGNANCY; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHESUS MONKEY;

ANIMALIA; MACACA MULATTA; PRIMATES;

EID: 64549127361     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.03946.x     Document Type: Conference Paper

References (10)

1. Weiss, G., E.M. O'Byrne & B.G. Steinetz. 1976. Re-laxin: A product of the human corpus luteum of pregnancy. Science 194: 948-949.
2. Hsu, S.Y., K. Nakabayashi, S. Nishi, et al. 2002. Activation of orphan receptors by the hormone relaxin. Science 295: 671-674.
3. Shirota, K., K. Tateishi, T. Koji, et al. 2005. Early human preantral follicles have relaxin and relaxin receptor (LGR7), and relaxin promotes their development. J. Clin. Endocrinol. Metab. 90: 516-521.
4. Duffy, D.M., T.R. Wells, G.J. Haluska, et al. 1997. The ratio of progesterone receptor isoforms changes in the monkey corpus luteum during the luteal phase of the menstrual cycle. Biol. Reprod. 57: 693-699.
5. Duffy, D.M., D.R. Stewart & R.L. Stouffer. 1999. Titrating luteinizing hormone replacement to sustain the structure and function of the corpus luteum after gonadotropin-releasing hormone antagonist treatment in rhesus monkeys. J. Clin. Endocrinol. Metab. 84: 342-349.
6. Mazella, J., M. Tang & L. Tseng. 2004. Disparate effects of relaxin and TGFβ1: Relaxin increases, but TGFβ1 inhibits, the relaxin receptor and the production of IGFBP-1 in human endome-trial stromal/decidual cells. Hum. Reprod. 19: 1513-1518.
7. Maruo, N., K. Nakabayashi, S. Wakahashi, et al. 2007. Effects of recombinant H2 relaxin on the expression of matrix metalloproteinases and tissue inhibitor metalloproteinase in cultured early pla-cental extravillous trophoblasts. Endocrine 32: 303-310.
8. Jeyabalan, A., L.J. Kerchner, M.C. Fisher, et al. 2006. Matrix metalloproteinase-2 activity, protein, mRNA, and tissue inhibitors in small arteries from pregnant and relaxin-treated nonpregnant rats. J. Appl. Physiol. 100: 1955-1963.
9. Young, K.A., J.D. Hennebold & R.L. Stouffer. 2002. Dynamic expression of mRNAs and proteins for matrix metalloproteinases and their tissue inhibitors in the primate corpus luteum during the menstrual cycle. Mol. Hum. Reprod. 8: 833-840.
10. Bogan, R.L., M.J. Murphy, R.L. Stouffer, et al. 2008. Systematic determination of differential gene expression in the primate corpus luteum during the luteal phase of the menstrual cycle. Mol. Endocrinol. 22: 1260-1273.