Non-nucleoside reverse transcriptase inhibitors (Part 18): Synthesis and anti-HIV activity of 4-allylamino or 4-azido substituted diaryltriazines

Yaoxue Xuebao

Volumn 44, Issue 2, 2009, Pages 145-149

  Yuan zhen, Xiong ^a   Hai rong, H U ^b   Fen er, Chen ^a,c   Jan, Balzarini ^d   Christophe, Pannecouque ^d   De Erik, Clercq ^d  

^a School of Pharmacy   (China)

^b Institute of Life Science   (China)

^c FUDAN UNIVERSITY   (China)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

4 allyl diaryltriazine; 4 azido diaryl tiazine; Anti hiv; Non nucleoside reverse transcriptase inhibitors

Indexed keywords

ALLYL COMPOUND; AMINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; AZIDE; DIDANOSINE; NEVIRAPINE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TRIAZINE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; IC 50; MOLECULAR DOCKING; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS MUTANT; VIRUS REPLICATION; VIRUS STRAIN; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVE SITE; IC50; SYNTHESIS;

ANTI-HIV AGENTS; CATALYTIC DOMAIN; HIV-1; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; REVERSE TRANSCRIPTASE INHIBITORS; TRIAZINES;

EID: 64549121587     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Feng XQ, Liang YH, Zeng ZS, et al. Structural modifications of DAPY analogues with potent anti-HIV activity [J]. Chem Med Chem. In press.
2. Xiong YZ, Chen FE, Balzarini J, et al. Non-nucleoside HIV-1 reverse transcriptase inhibitors Part 13. synthesis of fluorine-containing diaryltriazine derivatives and in vitro anti-HIV evaluation against wild-type strain [J]. Chem Biodiver, in press.
3. Xiong YZ, Chen FE, Balzarini J, et al. Non-nucleoside HIV-1 reverse transcriptase inhibitors, Part 11. structural modulations of diaryltriazines with potent anti-HIV activity [J]. Eur J Med Chem, 2008, 1230-1236.
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6. Ludovicia DW, Kavash RW, Kukla MJ, et al. Evolution of anti-HIV candidates part 2: diaryltriazine (DATA) analogues [J]. Bioorg Med Chem Lett, 2001, 11: 2229-2234.