Equine cytochrome P450 2C92: cDNA cloning, expression and initial characterization

Archives of Biochemistry and Biophysics

Volumn 485, Issue 1, 2009, Pages 49-55

  DiMaio Knych, H K ^a   DeStefano Shields, C ^b   Buckpitt, A R ^b   Stanley, S D ^a  

^a School of Veterinary Medicine   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

CYP2C; CYP450; Diclofenac; Horse; Mephenytoin; Phase I metabolism; Tolbutamide; Warfarin

Indexed keywords

COMPLEMENTARY DNA; CYTOCHROME P450 2C; CYTOCHROME P450 2C92; DICLOFENAC; OXIDOREDUCTASE; OXYGENASE; RECOMBINANT PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TOLBUTAMIDE; UNCLASSIFIED DRUG; WARFARIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; ENZYME ACTIVITY; ENZYME METABOLISM; FEMALE; GENE EXPRESSION; GENE SEQUENCE; HORSE; LIVER; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PURIFICATION;

ANIMALS; BIOCATALYSIS; CLONING, MOLECULAR; CYTOCHROME P-450 ENZYME SYSTEM; DICLOFENAC; DNA, COMPLEMENTARY; GENE EXPRESSION; HORSES; HUMANS; KINETICS; LIVER; MOLECULAR SEQUENCE DATA; SPECIES SPECIFICITY; SPODOPTERA; SUBSTRATE SPECIFICITY;

EQUIDAE;

EID: 64549119690     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2009.02.009     Document Type: Article

References (17)

1. Chauret N., Gauthier A., Martin J., and Nicoll-Griffith D.A. Drug Metab. Dispos. 10 (1997) 1130-1136
2. Nebbia C., Dacasto M., Rossetto Giaccherino A., Giuliano Albo A., and Carletti M. Vet. J. 165 (2003) 53-64
3. Lakrtiz J., Winder B.S., Noorouz-Zadeh J., Huang T.L., Buckpitt A.R., Hammock B.D., et al. Am. J. Vet. Res. 61 (2000) 152-157
4. Shimada T., Yamazaki H., Mimura M., Inui Y., and Guengerich F.P. J. Pharmacol. Exp. Ther. 270 (1994) 414-423
5. Omura T., and Sato R. J. Biol. Chem. 239 (1964) 2370-2378
6. Yasukochi Y., and Masters Y.B.S. J. Biol. Chem. 251 (1976) 5337-5344
7. Kumar V., Rock D.A., Warren C.J., Tracy T.S., and Wahlstrom J.L. Drug Metab. Dispos. 34 (2006) 1903-1908
8. Yokoyama T., Ohashi H., Kuge H., Kanehiro H., Iwata M., Yamato M., and Nakajima Y. Am. J. Transplant. 6 (2006) 50-59
9. Shaw P.M., Hosea N.A., Thompson D.V., Lenius J.M., and Guengerich F.P. Arch. Biochem. Biophys. 348 (1997) 107-115
10. Shimada T., Mernaugh R.L., and Guengerich F.P. Arch. Biochem. Biophys. 435 (2005) 207-216
11. Locuson C.W., Wienkers L.C., Jones J.P., and Tracy T.S. Drug Metab. Dispos. 35 (2007) 1174-1181
12. Yamazaki H., Nakamura M., Komatsu T., Ohyama K., Hatanaka N., Asahi S., Shimada N., Guengerich F.P., Shimada T., Nakajima M., et al. Protein Expr. Purif. 24 (2002) 329-337
13. Gruenke L.D., Konopka K., Cadieu M., and Waskell L. J. Biol. Chem. 270 (1995) 24707-24718
14. Jushchyshyn M.I., Hutzler J.M., Schrag M.L., and Wienkers L.C. Arch. Biochem. Biophys. 438 (2005) 21-28
15. Tyden E., Olsen L., Tallkvist J., Tjalve H., and Larsson P. Res. Vet. Sci. 85 (2008) 80-85
16. Shou M., Norcross R., Sandig G., Lu P., Li Y., Lin Y., Mei Q., Rodrigues D., and Rushmore T.H. Drug Metab. Dispos. 31 (2003) 1161-1169
17. D. Fu, A. Braun, B. Morrissey, V. Robillo, in: Proceedings of the 16th International Conference of Racing Analysts and Veterinarians, 2006, pp. 463-468.