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Volumn 66, Issue 8, 2009, Pages 715-726

Maraviroc: A coreceptor CCR5 antagonist for management of HIV infection

Author keywords

[No Author keywords available]

Indexed keywords

APLAVIROC; ATAZANAVIR; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; CHEMOKINE RECEPTOR CXCR4; CLARITHROMYCIN; EFAVIRENZ; ENFUVIRTIDE; ITRACONAZOLE; KETOCONAZOLE; LOPINAVIR; MARAVIROC; MIDAZOLAM; ORAL CONTRACEPTIVE AGENT; PLACEBO; PROTEINASE INHIBITOR; RIFAMPICIN; RITONAVIR; SAQUINAVIR; TELITHROMYCIN; TENOFOVIR; TIPRANAVIR; VIRUS RNA;

EID: 64549111285     PISSN: 10792082     EISSN: None     Source Type: Journal    
DOI: 10.2146/ajhp080206     Document Type: Review
Times cited : (38)

References (52)
  • 1
    • 35548984868 scopus 로고    scopus 로고
    • CCR5 antagonists in the treatment of treatment-experienced patients infected with CCR5 tropic HIV-1
    • Lorenzen T, Stoehr A, Walther I et al. CCR5 antagonists in the treatment of treatment-experienced patients infected with CCR5 tropic HIV-1. Eur J Med Res. 2007; 12:419-25.
    • (2007) Eur J Med Res , vol.12 , pp. 419-425
    • Lorenzen, T.1    Stoehr, A.2    Walther, I.3
  • 2
    • 64549126727 scopus 로고    scopus 로고
    • Selzentry (maraviroc) package insert. New York: Pfizer; 2007 Aug
    • Selzentry (maraviroc) package insert. New York: Pfizer; 2007 Aug.
  • 3
    • 27644510382 scopus 로고    scopus 로고
    • Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type I activity
    • Dorr P, Westby M, Dobbs S et al. Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type I activity. Antimicrob Agents Chemother. 2005; 49: 4721-32.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4721-4732
    • Dorr, P.1    Westby, M.2    Dobbs, S.3
  • 4
    • 0030002637 scopus 로고    scopus 로고
    • HIV-1 entry cofactor. Functional cdna cloning of a seven-transmembrane, g protein-coupled receptor
    • Feng Y, Broder CC, Kennedy PE et al. HIV-1 entry cofactor. Functional cdna cloning of a seven-transmembrane, g protein-coupled receptor. Science. 1996; 272:872-7.
    • (1996) Science , vol.272 , pp. 872-877
    • Feng, Y.1    Broder, C.C.2    Kennedy, P.E.3
  • 5
    • 15844419153 scopus 로고    scopus 로고
    • Identification of a major co-receptor for primary isolates of HIV-1
    • Deng H, Liu R, Ellmeier W et al. Identification of a major co-receptor for primary isolates of HIV-1. Nature. 1996; 381:661-6.
    • (1996) Nature , vol.381 , pp. 661-666
    • Deng, H.1    Liu, R.2    Ellmeier, W.3
  • 6
    • 15844389650 scopus 로고    scopus 로고
    • 4+ cells is mediated by the chemokine receptor cc-ckr-5
    • 4+ cells is mediated by the chemokine receptor cc-ckr-5. Nature 1996; 381:667-73.
    • (1996) Nature , vol.381 , pp. 667-673
    • Dragic, T.1    Litwin, V.2    Allaway, G.P.3
  • 7
    • 35548938219 scopus 로고    scopus 로고
    • Tropism switch in patients infected with HIV-1 and its clinical implications for the treatment with CCR5-receptor inhibitors
    • Arasteh K, Stocker H. Tropism switch in patients infected with HIV-1 and its clinical implications for the treatment with CCR5-receptor inhibitors. Eur J Med Res. 2007; 12:397-402.
    • (2007) Eur J Med Res , vol.12 , pp. 397-402
    • Arasteh, K.1    Stocker, H.2
  • 8
    • 35548939825 scopus 로고    scopus 로고
    • The epidemiology of HIV coreceptor tropism
    • Hoffman C. The epidemiology of HIV coreceptor tropism. Eur J Med Res. 2007; 12:385-90.
    • (2007) Eur J Med Res , vol.12 , pp. 385-390
    • Hoffman, C.1
  • 10
    • 55049103539 scopus 로고    scopus 로고
    • Efficacy and safety of maraviroc plus optimized background therapy in viraemic, antiretroviral treatment-experienced patients infected with CCR5-tropic HIV-1 in Europe, Australia, and North America (MOTIVATE 2): 48 week results
    • Paper presented at, Madrid, Spain;
    • th European AIDS Conference. Madrid, Spain; 2007.
    • (2007) th European AIDS Conference
    • Fatkenheuer, G.1    Konourina, I.2    Nelson, M.3
  • 11
    • 35548983281 scopus 로고    scopus 로고
    • A multicenter, randomized, double-blind, comparative trial of a novel CCR5 antagonist, mara-viroc vs. efavirenz, both in combination with Combivir (zidovudine/lamivudine), for the treatment of antiretroviral naive patients infected R5 HIV 1: Week 48 results of the MERIT study
    • Paper presented at, Sydney, Australia;
    • th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention. Sydney, Australia; 2007.
    • (2007) th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention
    • Saag, M.1    Ive, P.2    Heera, J.3
  • 13
    • 33746160257 scopus 로고    scopus 로고
    • HIV-1 coreceptor use in triple-class treatment-experienced patients: Baseline prevelance, correlates and relationship to enfuvirtide response
    • Melby T. DeSpirito M, De Masi R et al. HIV-1 coreceptor use in triple-class treatment-experienced patients: baseline prevelance, correlates and relationship to enfuvirtide response. J Infect Dis. 2006; 194:238-46.
    • (2006) J Infect Dis , vol.194 , pp. 238-246
    • Melby, T.1    DeSpirito, M.2    De Masi, R.3
  • 14
    • 33846932573 scopus 로고    scopus 로고
    • HIV type 1 chemokine coreceptor use among antiretroviral-experienced patients screened for a clinical trial of a CCR5 inhibitor: AIDS clinical trial group A5211
    • Wilkin TJ, Su Z, Kuritzkes DR et al. HIV type 1 chemokine coreceptor use among antiretroviral-experienced patients screened for a clinical trial of a CCR5 inhibitor: AIDS clinical trial group A5211. Clin Infect Dis. 2007; 44:591-4.
    • (2007) Clin Infect Dis , vol.44 , pp. 591-594
    • Wilkin, T.J.1    Su, Z.2    Kuritzkes, D.R.3
  • 15
    • 33846623260 scopus 로고    scopus 로고
    • Development and characterization of a novel single-cycle recombinant-virus assay to determine human immunodeficiency virus type 1 coreceptor tropism
    • Whitcomb JM, Huang W, Fransen S et al. Development and characterization of a novel single-cycle recombinant-virus assay to determine human immunodeficiency virus type 1 coreceptor tropism. Antimi-crob Agents Chemother. 2007; 51:566-75.
    • (2007) Antimi-crob Agents Chemother , vol.51 , pp. 566-575
    • Whitcomb, J.M.1    Huang, W.2    Fransen, S.3
  • 18
    • 33847237614 scopus 로고    scopus 로고
    • Reduced maximal inhibition in phenotyp-ic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry
    • Westby M, Smith-Burchnell C, Mori J et al. Reduced maximal inhibition in phenotyp-ic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry.J Virol. 2007; 81:2359-71.
    • (2007) J Virol , vol.81 , pp. 2359-2371
    • Westby, M.1    Smith-Burchnell, C.2    Mori, J.3
  • 19
    • 30744447460 scopus 로고    scopus 로고
    • Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1
    • Fatkenheuer G, Pozniak A, Johnson MA et al. Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1. Nat Med. 2005; 11:1170-2.
    • (2005) Nat Med , vol.11 , pp. 1170-1172
    • Fatkenheuer, G.1    Pozniak, A.2    Johnson, M.A.3
  • 20
    • 33646443202 scopus 로고    scopus 로고
    • Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-l-infected patients following treatment with the CCR5 antagonist maraviroc is from a pre-treatment CXCR4-using virus reservoir
    • 20
    • 20.Westby M, Lewis M, Whitcomb J et al. Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-l-infected patients following treatment with the CCR5 antagonist maraviroc is from a pre-treatment CXCR4-using virus reservoir. J Virol. 2006; 80:4909-20.
    • (2006) J Virol , vol.80 , pp. 4909-4920
    • Westby, M.1    Lewis, M.2    Whitcomb, J.3
  • 21
    • 3142679567 scopus 로고    scopus 로고
    • Intrinsic obstacles to human immunodeficiency virus type 1 coreceptor switching
    • Pastore C, Ramos A, Mosier DE. Intrinsic obstacles to human immunodeficiency virus type 1 coreceptor switching. J Virol. 2004; 78:7565-74.
    • (2004) J Virol , vol.78 , pp. 7565-7574
    • Pastore, C.1    Ramos, A.2    Mosier, D.E.3
  • 23
    • 15344350690 scopus 로고    scopus 로고
    • Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV
    • Walker DK, Abel S, Comby P et al. Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV. Drug Metab Dispos. 2005; 33:587-95.
    • (2005) Drug Metab Dispos , vol.33 , pp. 587-595
    • Walker, D.K.1    Abel, S.2    Comby, P.3
  • 28
    • 33749839996 scopus 로고    scopus 로고
    • Safety and efficacy of maraviroc, a novel CCR5 antagonist, when used in combination with optimized background therapy for the treatment of antiretroviral-xperienced subjects infected with dual/mixed-tropic HIV-1: 24 week results of a phase 2b exploratory trial
    • Paper presented at, Toronto, Canada;
    • Mayer H, van der Ryst E, Saag M et al. Safety and efficacy of maraviroc, a novel CCR5 antagonist, when used in combination with optimized background therapy for the treatment of antiretroviral-xperienced subjects infected with dual/mixed-tropic HIV-1: 24 week results of a phase 2b exploratory trial. Paper presented at XVI International AIDS Conference. Toronto, Canada; 2006.
    • (2006) XVI International AIDS Conference
    • Mayer, H.1    van der Ryst, E.2    Saag, M.3
  • 31
    • 33745581733 scopus 로고    scopus 로고
    • GlaxoSmifhKline ends aplaviroc trials
    • Crabb C. GlaxoSmifhKline ends aplaviroc trials. AIDS. 2006; 20:641.
    • (2006) AIDS , vol.20 , pp. 641
    • Crabb, C.1
  • 34
    • 34347379935 scopus 로고    scopus 로고
    • Phase 2 study of the safety and efficacy of vicri-viroc, a CCR5 inhibitor, in HIV-1-infected, treatment-experienced patients: AIDS clinical trial group 5211
    • Gulick RM, Su Z, Flexner C et al. Phase 2 study of the safety and efficacy of vicri-viroc, a CCR5 inhibitor, in HIV-1-infected, treatment-experienced patients: AIDS clinical trial group 5211. J Infect Dis. 2007; 196:304-12.
    • (2007) J Infect Dis , vol.196 , pp. 304-312
    • Gulick, R.M.1    Su, Z.2    Flexner, C.3
  • 36
    • 85039092610 scopus 로고    scopus 로고
    • Antiviral Drugs Advisory Committee briefing document,April 24, accessed 2007 Apr 27
    • Food and Drug Administration. Maraviroc tablets NDA 22-128: Antiviral Drugs Advisory Committee briefing document,April 24, 2007. www.fda.gov/OHRMS/ DOCKETS/AC/07/briefing/2007-4283bl-01-Pfizer.pdf (accessed 2007 Apr 27).
    • (2007) Maraviroc tablets NDA , pp. 22-128
  • 40
    • 35649022566 scopus 로고    scopus 로고
    • A study to investigate the combined coadministration of P450 CYP3A4 inhibitors and inducers on the pharmacokinetics of the novel CCR5 inhibitor UK-427,857
    • Paper presented at, Glasgow, Scotland;
    • Muirhead G, Ridgway C, Leahy D et al. A study to investigate the combined coadministration of P450 CYP3A4 inhibitors and inducers on the pharmacokinetics of the novel CCR5 inhibitor UK-427,857. Paper presented at 7th International Congress on Drug Therapy in HIV Infection. Glasgow, Scotland; 2004.
    • (2004) 7th International Congress on Drug Therapy in HIV Infection
    • Muirhead, G.1    Ridgway, C.2    Leahy, D.3
  • 42
    • 22244486859 scopus 로고    scopus 로고
    • Effect of UK-427,857 on the pharmacokinetics of oral contraceptive steroids and the pharmacokinetics of UK-427-857 in healthy young women
    • Paper presented at, Chicago, IL;
    • Abel S, Whitlock L, Ridgway C et al. Effect of UK-427,857 on the pharmacokinetics of oral contraceptive steroids and the pharmacokinetics of UK-427-857 in healthy young women. Paper presented at 43rd International Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL; 2003.
    • (2003) 43rd International Conference on Antimicrobial Agents and Chemotherapy
    • Abel, S.1    Whitlock, L.2    Ridgway, C.3
  • 44
    • 64549090855 scopus 로고    scopus 로고
    • Drug Topics red book 2008. Montvale, NJ: Thomson PDR; 2008:709.
    • Drug Topics red book 2008. Montvale, NJ: Thomson PDR; 2008:709.
  • 46
    • 64549146457 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Trial of Maraviroc (UK-427,857) in Combination with Optimized Background Therapy Versus Optimized Background Therapy Alone for the Treatment of HIV-1 Infected Subjects (MOTIVATE 1). http://clinicaltrials.gov/ show/NCT00098306?order=9 (accessed 2008 Feb 18).
    • ClinicalTrials.gov. Trial of Maraviroc (UK-427,857) in Combination with Optimized Background Therapy Versus Optimized Background Therapy Alone for the Treatment of HIV-1 Infected Subjects (MOTIVATE 1). http://clinicaltrials.gov/ show/NCT00098306?order=9 (accessed 2008 Feb 18).
  • 47
    • 64549162201 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Trial of Maraviroc (UK-427,857) in Combination with Optimized Background Therapy Versus Optimized Background Therapy Alone for the Treatment of HIV-1 Infected Subjects (MOTIVATE 2). http://clinicaltrials.gov/ show/NCT00098722?order=5 (accessed 2008 Feb 18).
    • ClinicalTrials.gov. Trial of Maraviroc (UK-427,857) in Combination with Optimized Background Therapy Versus Optimized Background Therapy Alone for the Treatment of HIV-1 Infected Subjects (MOTIVATE 2). http://clinicaltrials.gov/ show/NCT00098722?order=5 (accessed 2008 Feb 18).
  • 48
    • 64549126287 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Trial of Maraviroc (UK-427,857) in Combination with Zidovudine/Lamivudine Versus Efa-virenz in Combination with Zidovudine/ Lamivudine (MERIT), http://clinicaltrials.gov/show/NCT00098293? order=8 (accessed 2008 Feb 18).
    • ClinicalTrials.gov. Trial of Maraviroc (UK-427,857) in Combination with Zidovudine/Lamivudine Versus Efa-virenz in Combination with Zidovudine/ Lamivudine (MERIT), http://clinicaltrials.gov/show/NCT00098293? order=8 (accessed 2008 Feb 18).
  • 49
    • 64549124143 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Trial of maraviroc (UK-427,857) in combination with optimized background therapy versus optimized background therapy alone for the treatment of HIV-] infected subjects, http://clinicaltrials.gov/show/ NCT00098748?order=6 (accessed 2008 Feb 18).
    • ClinicalTrials.gov. Trial of maraviroc (UK-427,857) in combination with optimized background therapy versus optimized background therapy alone for the treatment of HIV-] infected subjects, http://clinicaltrials.gov/show/ NCT00098748?order=6 (accessed 2008 Feb 18).
  • 51
    • 84868927173 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Standard Antiretrovi-ral Versus Multi-Class Therapy in Acutely HIV-1 Infected Antiretroviral-Naïve Subjects (ADARC 2007-01). http://clinicaltrials.gov/show/NCT00525733?order=4 (accessed 2008 Feb 18).
    • ClinicalTrials.gov. Standard Antiretrovi-ral Versus Multi-Class Therapy in Acutely HIV-1 Infected Antiretroviral-Naïve Subjects (ADARC 2007-01). http://clinicaltrials.gov/show/NCT00525733?order=4 (accessed 2008 Feb 18).


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