Evolution of the antibiotic resistance protein, FosA, is linked to a catalytically promiscuous progenitor

Biochemistry

Volumn 48, Issue 9, 2009, Pages 1847-1849

  Brown, Daniel W ^a   Schaab, Matthew R ^a   Birmingham, William R ^a   Armstrong, Richard N ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC RESISTANCES; EPOXIDE HYDROLASE; FOSFOMYCIN; GENE PRODUCTS; GLUTATHIONE TRANSFERASE; HOMOLOGOUS RECOMBINATIONS; IN-VITRO; MESORHIZOBIUM MALOTI; PATHOGENIC MICROORGANISMS; PSEUDOMONAS AERUGINOSA; RECOMBINANT PROTEINS;

ANTIBIOTICS; MICROORGANISMS;

PROTEINS;

EPOXIDE HYDROLASE; FOSFOMYCIN; GENE PRODUCT; GLUTATHIONE TRANSFERASE; PROTEIN FOSA; PROTEIN FOSX; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; CATALYSIS; CONTROLLED STUDY; ESCHERICHIA COLI; MESORHIZOBIUM; MESORHIZOBIUM LOTI; NONHUMAN; OPERON; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SEQUENCE ANALYSIS;

ALPHAPROTEOBACTERIA; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MICROBIAL; EVOLUTION, MOLECULAR; FOSFOMYCIN; GLUTATHIONE; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

MESORHIZOBIUM LOTI; PSEUDOMONAS AERUGINOSA;

EID: 64549108884     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900078q     Document Type: Article

References (9)

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