Inhibition of toxoplasma gondii and plasmodium falciparum infections in vitro by NSC3852, a redox active antiproliferative and tumor cell differentiation agent

Journal of Parasitology

Volumn 95, Issue 1, 2009, Pages 215-223

  Strobl, Jeannine S ^a   Seibert, Christopher W ^a,b   Li, Yunbo ^a,b   Nagarkatti, Rana ^a,b   Mitchell, Sheila M ^a,c   Rosypal, Alexa C ^a,c   Rathore, Dharmendar ^a,b   Lindsay, David S ^a,c  

^a EDWARD VIA COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

^b VIRGINIA BIOINFORMATICS INSTITUTE   (United States)

^c VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; ANTIPROTOZOAL AGENT; NITRIC OXIDE SYNTHASE; NSC 109814; NSC 3852; NSC 68553; NSC 74050; NSC 74949; PEROXYNITRITE; QUINOLINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG; 5 NITROSO 8 QUINOLINOL; 5-NITROSO-8-QUINOLINOL; ANTIOXIDANT; DIAGNOSTIC AGENT; FLUORESCENT DYE; NITRIC OXIDE; NITROSO DERIVATIVE; ORGANIC COMPOUND; QUINOLINOL DERIVATIVE; SYBR GREEN I;

ALGORITHM; ANTIMICROBIAL ACTIVITY; AROMATIC HYDROCARBON; BIOASSAY; MEDICINE; ORGANIC COMPOUND; PARASITOLOGY; PROTOZOAN; PUBLIC HEALTH; REDOX CONDITIONS; TUMOR;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG STRUCTURE; ERYTHROCYTE; FIBROBLAST; HUMAN; HUMAN CELL; MALARIA FALCIPARUM; OXIDATION REDUCTION REACTION; TACHYZOITE; TOXOPLASMA GONDII; TOXOPLASMOSIS; ANIMAL; CELL CULTURE; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG SENSITIVITY; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PARASITOLOGY; PLASMODIUM FALCIPARUM; TOXOPLASMA;

PLASMODIUM FALCIPARUM; TOXOPLASMA GONDII;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; ANTIPROTOZOAL AGENTS; CELL LINE; CELLS, CULTURED; ERYTHROCYTES; FIBROBLASTS; FLUORESCENT DYES; HUMANS; HYDROXYQUINOLINES; NITRIC OXIDE; NITROSO COMPOUNDS; ORGANIC CHEMICALS; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; QUINOLINES; REACTIVE OXYGEN SPECIES; TOXOPLASMA;

EID: 64549093685     PISSN: 00223395     EISSN: None     Source Type: Journal    
DOI: 10.1645/GE-1608.1     Document Type: Article

References (51)

1. ABOU-BACAR, A., A. W. PFAFF, V. LETSCHER-BRU, D. FILISETTI, R. RAJAPAKSE, E. ANTONI, O. VILLARD, J. P. KLEIN, AND E. CANDOLFI. 2004. Role of gamma interferon and T cells in congenital Toxo-plasma transmission. Parasite Immunology 26: 315-318.
2. BAGGISH, A. L., AND D. R. HILL. 2002. Antiparasitic agent atovaquone. Antimicrobial Agents and Chemotherapy 46: 1163-1173.
3. BARSOUM, R. S. 2006. Parasitic infections in transplant recipients. Nature Clinical Practice Nephrology 2: 490-503.
4. BEAMAN, M. H., C. S. SUBAUSTE, S. Y. WONG, AND J. S. REMINGTON. 1994. Toxoplasma-macrophage interactions. Immunology Series 60: 475-493.
5. BENNETT, T. N., M. PAGUIO, B. GLIGORIJEVIC, C. SEUDIEU, A. D. KOSAR, E. DAVIDSON, AND P. D. ROEPE. 2004. Novel, rapid, and inexpensive cell-based quantification of antimalarial drug efficacy. Antimicrobial Agents and Chemotherapy 48: 1807-1810.
6. BUZONI-GATEL, D., AND C. WERTS. 2006. Toxoplasma gondii and sub-version of the immune system. Trends in Parasitology 22: 448-452.
7. DE BIASE, P. M., A. G. TURJANSKI, D. A. ESTRIN, AND F. DOCTOROVICH. 2005. Mechanisms of NO release by N1-nitrosomelatonin: Nucle-ophilic attack versus reducing pathways. Journal of Organic Chemistry 70: 5790-5798.
8. DENTON, H., C. W. ROBERTS, J. ALEXANDER, K. W. THONG, AND G. H. COOMBS. 1996. Enzymes of energy metabolism in the bradyzoites and tachyzoites of Toxoplasma gondii. FEMS Microbiological Letters 137: 103-108.
9. DING, M., L. Y. KWOK, D. SCHLUTER, C. CLAYTON, AND D. SOLDATI. 2004. The antioxidant systems in Toxoplasma gondii and the role of cytosolic catalase in defence against oxidative injury. Molecular Microbiology 51: 47-61.
10. DUBEY, J. P., D. E. HILL, J. L. JONES, A. W. HIGHTOWER, E. KIRKLAND, J. M. ROBERTS, P. L. MARCET, T. LEHMANN, M. C. VIANNA, K. MISKA, ET AL. 2005. Prevalence of viable Toxoplasma gondii in beef, chicken, and pork from retail meat stores in the United States: Risk assessment to consumers. Journal of Parasitology 91: 1082-1093.
11. FLEGR, J. 2007. Effects of Toxoplasma on human behavior. Schizophrenia Bulletin 33: 757-760.
12. FLOREANI, M., AND F. CARPENEDO. 1991. Modifications of cardiac contractility by redox cycling alkylating and mixed redox cycling/al-kylating quinones. Journal of Pharmacology and Experimental Therapeutics 256: 243-248.
13. FRANCISCO FDE, M., S. L. DE SOUZA, S. M. GENNARI, S. R. PINHEIRO, V. MURADIAN, AND R. M. SOARES. 2006. Seroprevalence of toxoplas-mosis in a low-income community in the Sao Paulo municipality, SP, Brazil. Revista do Instituto de Medicina Tropical de Sao Paulo 48: 167-170.
14. FRANCO-PAREDES, C., N. ROUPHAEL, J. MENDEZ, E. FOLCH, A. J. RODRIGUEZ-MORALES, J. I. SANTOS, AND J. W. HURST. 2007. Cardiac manifestations of parasitic infections. Part 2: Parasitic myocardial disease. Clinical Cardiology 30: 218-222.
15. HEIGOLD, S., C. SERS, W. BECHTEL, B. IVANOVAS, R. SCHAFER, AND G. BAUER. 2002. Nitric oxide mediates apoptosis induction selectively in transformed fibroblasts compared to nontransformed fibroblasts. Carcinogenesis 23: 929-941.
16. HENRY, T. R., AND K. B. WALLACE. 1996. Differential mechanisms of cell killing by redox cycling and arylating quinones. Archives of Toxicology 70: 482-489.
17. HOLLAND, G. N. 2004. Ocular toxoplasmosis: A global reassessment. Part II: Disease manifestations and management. American Journal of Ophthalmology 137: 1-17.
18. JEANNEL, D., G. NIEL, D. COSTAGLIOLA, M. DANIS, B. M. TRAORE, AND M. GENTILINI. 1988. Epidemiology of toxoplasmosis among pregnant women in the Paris area. International Journal of Epidemiology 17: 595-602.
19. JONES, J. L., D. KRUSZON-MORAN, K. SANDERS-LEWIS, AND M. WILSON. 2007. Toxoplasma gondii infection in the United States, 1999-2004, decline from the prior decade. American Journal of Tropical Medicine and Hygiene 77: 405-410.
20. -, A. LOPEZ, M. WILSON, J. SCHULKIN, AND R. GIBBS. 2001. Congenital toxoplasmosis: A review. Obstetrical and Gynecological Survey 56: 296-305.
21. KASPER, L. H., AND D. BUZONI-GATEL. 1998. Some opportunistic parasitic infections in AIDS: Candidiasis, pneumocystosis, cryptospo-ridiosis, toxoplasmosis. Parasitology Today 14: 150-156.
22. LAMBROS, C., AND J. P. VANDERBERG. 1979. Synchronization of Plasmodium falciparum erythrocytic stages in culture. Journal of Par-asitology 65: 418-420.
23. LI, Y., AND M. A. TRUSH. 1998. Diphenylene iodonium, an NAD(P)H oxidase inhibitor, also potently inhibits mitochondrial reactive oxygen species production. Biochemical Biophysical Research Communications 253: 295-299.
24. LINDOVA, J., M. NOVOTNA, J. HAVLICEK, E. JOZIFKOVA, A. SKALLOVA, P. KOLBEKOVA, Z. HODNY, P. KODYM, AND J. FLEGR. 2006. Gender differences in behavioural changes induced by latent toxoplasmo-sis. International Journal for Parasitology 36: 1485-1492.
25. LING, Y., Z. H. LI, K. MIRANDA, E. OLDFIELD, AND S. N. MORENO. 2007. The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of biphosphonates. Journal of Biological Chemistry 282: 30804-30816.
26. MARTIROSYAN, A., S. LEONARD, X. SHI, B. GRIFFITH, P. GANNETT, AND J. STROBL. 2006. Actions of a histone deacetylase inhibitor NSC3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor cells. Journal of Pharmacology and Experimental Therapeutics 317: 546-552.
27. MARTIROSYAN, A. R., R. RAHIM-BATA, A. B. FREEMAN, C. D. CLARKE, R. L. HOWARD, AND J. S. STROBL. 2004. Differentiation-inducing quinolines as experimental breast cancer agents in the MCF-7 human breast cancer cell model. Biochemical Pharmacology 68: 1729-1738.
28. MASKOS, Z., AND G. W. WINSTON. 1994. Mechanism of p-nitrosophenol reduction catalyzed by horse liver and human pi-alcohol dehydro-genase (ADH): Human pi-ADH as a quinone reductase. Journal of Biological Chemistry 269: 31579-31584.
29. MCCARTHY, S. M., AND C. D. DAVIS. 2003. Prooxidant diet provides protection during murine infection with Toxoplasma gondii. Journal of Parasitology 89: 886-894.
30. MILLER, R., X. WEN, B. DUNFORD, X. WANG, AND Y. SUZUKI. 2006. Cytokine production of CD8+ immune T cells but not of CD4+ T cells from Toxoplasma gondii-infected mice is polarized to a type 1 response following stimulation with tachyzoite-infected macrophages. Journal of Interferon Cytokine Research 26: 787-792.
31. MONTOYA, J. G., AND F. ROSSO. 2005. Diagnosis and management of toxoplasmosis. Clinical Perinatology 32: 705-726.
32. MORTENSEN, P. B., B. NORGAARD-PEDERSEN, B. L. WALTOFT, T. L. SOR-ENSEN, D. HOUGAARD, AND R. H. YOLKEN. 2007. Early infections of Toxoplasma gondii and the later development of schizophrenia. Schizophrenia Bulletin 33: 741-744.
33. PEASLEE, K. A., AND A. C. ANDERSON. 2001. Toward rational design of species-specific inhibitors of Pneumocystis carinii thymidylate synthase and Toxoplasma gondii dihydrofolate reductase-thymidylate synthase. Journal of Eukaryotic Microbiology (Suppl.): 174S-175S.
34. PETERSEN, E. 2007. Toxoplasmosis. Seminars in Fetal Neonatal Medicine 12: 214-223.
35. PINO, P., B. J. FOTH, L. Y. KWOK, L. SHEINER, R. SCHEPERS, T. SOLDATI, AND D. SOLDATI-FAVRE. 2007. Dual targeting of antioxidant and metabolic enzymes to the mitochondrion and the apicoplast of Toxoplasma gondii. PLoS Pathology 3: e115.
36. POROIKOV, V. V., D. A. FILIMONOV, W.-D. IHLENFELDT, T. A. GLORIOZOVA, A. A. LAGUNIN, Y. V. BORODINA, A. V. STEPANCHIKOVA, AND M. C. NICKLAUS. 2003. PASS biological activity spectrum predictions in the enhanced open NCI database browser. Journal of Chemical Information and Computer Science 43: 228-236.
37. PORTUGAL, L. R., L. R. FERNANDES, G. C. CESAR, H. C. SANTIAGO, D. R. OLIVEIRA, N. M. SILVA, A. A. SILVA, J. LANNES-VIEIRA, R. M. ARANTES, R. T. GAZZINELLI, AND J. I. ALVAREZ-LEITE. 2004. Infection with Toxoplasma gondii increases atherosclerotic lesion in ApoE-deficient mice. Infection and Immunity 72: 3571-3576.
38. REBOUCAS, J. S., I. SPASOJEVIC, AND I. BATINIC-HABERLE. 2008. Pure manganese(III) 5,10,15,20-tetrakis(4-benzoic acid)porphyrin (Mn-TBAP) is not a superoxide dismutase mimic in aqueous systems: A case of structure-activity relationship as a watchdog mechanism in experimental therapeutics and biology. Journal of Biological and Inorganic Chemistry 13: 289-302.
39. ROGERS, N. M., C. A. PEH, R. FAULL, M. PANNELL, J. COOPER, AND G. R. RUSS. 2008. Transmission of toxoplasmosis in two renal allograft recipients receiving an organ from the same donor. Transplant Infectious Disease 10: 71-74.
40. SAED, G. M., H. M. ABU-SOUD, AND M. P. DIAMOND. 2004. Role of nitric oxide in apoptosis of human peritoneal and adhesion fibroblasts after hypoxia. Fertility and Sterility 82(Suppl. 3): 1198-1204.
41. SAYGI, G. 2001. The epidemiology of toxoplasmosis in Turkey - a review of the literature. Wiadomosci Parazytologiczne 47(Suppl. 1): 19-30.
42. SHEN, W. L., P. J. GAO, Z. O. CHE, K. D. JI, M. YIN, C. YAN, B. C. BERK, AND D. L. ZHU. 2006. NAD(P)H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation. Biochemistry Biophysics Research Communications 339: 337-343.
43. SHRESTHA, S. P., T. TOMITA, L. M. WEISS, AND A. ORLOFSKY. 2006. Proliferation of Toxoplasma gondii in inflammatory macrophages in vivo is associated with diminished oxygen radical production in the host cell. International Journal for Parasitology 36: 433-441.
44. STAFFORD, J. L., N. F. NEUMANN, AND M. BELOSEVIC. 2002. Macrophage-mediated innate host defense against protozoan parasites. Critical Reviews in Microbiology 28: 187-248.
45. STERIN-BORDA, L., C. FURLAN, B. ORMAN, AND E. BORDA. 2007. Differential regulation on human skin fibroblast by alpha1 adrenergic receptor subtypes. Biochemical Pharmacology 74: 1401-1412.
46. STROBL, J. S., M. CASSELL, S. M. MITCHELL, C. M. REILLY, AND D. S. LINDSAY. 2007. Scriptaid and suberoylanilide hydroxamic acid are histone deacetylase inhibitors with potent anti-Toxoplasma gondii activity in vitro. Journal of Parasitology 93: 694-700.
47. SUBSAI, K., S. KANOKSRI, C. SIWAPORN, L. HELEN, O. KANOKPORN, AND P. WANTANA. 2006. Neurological complications in AIDS patients receiving HAART: A 2-year retrospective study. European Journal of Neurology 13: 233-239.
48. TORREY, E. F., J. J. BARTKO, Z. R. LUN, AND R. H. YOLKEN. 2007. Antibodies to Toxoplasma gondii in patients with schizophrenia: A meta-analysis. Schizophrenia Bulletin 33: 729-736.
49. -, AND R. H. YOLKEN. 2007. Schizophrenia and toxoplasmosis. Schizophrenia Bulletin 33: 727-728.
50. TRAGER, W., AND J. B. JENSEN. 1976. Human malaria parasites in continuous culture. Science 193: 673-675.
51. YAZAR, S., M. GUR, I. OZDOGRU, O. YAMAN, A. OGUZHAN, AND I. SAHIN. 2006. Anti-Toxoplasma gondii antibodies in patients with chronic heart failure. Journal of Medical Microbiology 55(Pt. 1): 89-92.