Herpes virus-based recombinant herpes vectors: Gene therapy for pain and molecular tool for pain science

Gene Therapy

Volumn 16, Issue 4, 2009, Pages 502-508

  Yeomans, D C ^a   Wilson, S P ^b  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; ACID SENSING ION CHANNEL; CALCITONIN GENE RELATED PEPTIDE; ENKEPHALIN; HERPESVIRUS VECTOR; MU OPIATE RECEPTOR; POTASSIUM CHANNEL; POTASSIUM CHANNEL NAV1.7; PREPROENKEPHALIN; UNCLASSIFIED DRUG;

ANALGESIA; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ANTISENSE THERAPY; ARTHRITIS; DRUG MECHANISM; DRUG TARGETING; EXPRESSION VECTOR; GENE EXPRESSION; GENE FUNCTION; GENE SILENCING; GENETIC TRANSDUCTION; HUMAN; IMMUNOREACTIVITY; NONHUMAN; PAIN; PAIN ASSESSMENT; PANCREATITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR UPREGULATION; REVIEW; VALIDATION PROCESS; VIRAL GENE THERAPY;

ANIMALS; ENKEPHALINS; GENE SILENCING; GENE THERAPY; GENETIC VECTORS; HUMANS; PAIN; PROTEIN PRECURSORS; SIMPLEXVIRUS;

CYTOMEGALOVIRUS; HERPES; HERPESVIRIDAE; PRIMATES; RODENTIA;

EID: 64549090622     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2009.25     Document Type: Review

References (11)

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2. Yeomans DC, Jones T, Laurito CE, Lu Y, Wilson SP. Reversal of ongoing thermal hyperalgesia in mice by a recombinant herpesvirus that encodes human preproenkephalin. Mol Ther 2004; 9: 24-29.
3. Yeomans DC, Lu Y, Laurito CE, Peters MC, Vota-Vellis G, Wilson SP et al. Recombinant herpes vector-mediated analgesia in a primate model of hyperalgesia. Mol Ther 2006; 13: 589-597.
4. Yang H, McNearney TA, Chu R, Lu Y, Ren Y, Yeomans DC et al. Enkephalin-encoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model. Mol Pain 2008; 4: 8.
5. Lu Y, McNearney TA, Lin W, Wilson SP, Yeomans DC, Westlund KN. Treatment of inflamed pancreas with enkephalin encoding HSV-1 recombinant vector reduces inflammatory damage and behavioral sequelae. Mol Ther 2007; 15: 1812-1819.
6. Lu Y, McNearney TA, Wilson SP, Yeomans DC, Westlund KN. Joint capsule treatment with enkephalin-encoding HSV-1 recombinant vector reduces inflammatory damage and behavioural sequelae in rat CFA monoarthritis. Eur J Neurosci 2008; 27: 1153-1165.
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10. Yeomans DC, Levinson SR, Peters MC, Koszowski AG, Tzabazis AZ, Gilly WF et al. Decrease in inflammatory hyperalgesia by herpes vector-mediated knockdown of Nav1.7 sodium channels in primary afferents. Hum Gene Therapy 2005; 16: 271-277.
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