Management of Erectile Function by Penile Purinergic P2 Receptors in the Diabetic Rat

Journal of Urology

Volumn 181, Issue 5, 2009, Pages 2375-2382

  Gur, Serap ^a   Kadowitz, Philip J ^a   Abdel Mageed, Asim B ^a   Kendirci, Muammer ^a   Sikka, Suresh C ^a   Burnstock, Geoffrey ^a   Hellstrom, Wayne J G ^a  

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

diabetes mellitus; erectile dysfunction; penis; purinergic; rats, Sprague Dawley; receptors

Indexed keywords

2 METHYLTHIOADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; PURINERGIC P2 RECEPTOR; PURINERGIC P2X1 RECEPTOR; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y2 RECEPTOR; STREPTOZOCIN; URIDINE TRIPHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DIABETES MELLITUS; ELECTROSTIMULATION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SMOOTH MUSCLE RELAXATION;

ADENOSINE; ADENOSINE TRIPHOSPHATE; ANIMALS; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; PENILE ERECTION; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; STREPTOZOCIN; THIONUCLEOSIDES; URIDINE TRIPHOSPHATE;

EID: 64449083384     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2009.01.002     Document Type: Article

References (20)

1. Ralevic V., and Burnstock G. Receptors for purines and pyrimidines. Pharmacol Rev 50 (1998) 413
2. Burnstock G., and Knight G.E. Cellular distribution and functions of P2 receptor subtypes in different systems. Int Rev Cytol 240 (2004) 31
3. Burnstock G. Purine and pyrimidine receptors. Cell Mol Life Sci 64 (2007) 1471
4. Tong Y.C., Broderick G., Hypolite J., and Levin R.M. Correlations of purinergic, cholinergic and adrenergic functions in rabbit corporal cavernosal tissue. Pharmacology 45 (1992) 241
5. Takahashi Y., Ishii N., Lue T.F., and Tanagho E.A. Effects of adenosine on canine penile erection. J Urol 148 (1992) 1323
6. Lee H.Y., Bardini M., and Burnstock G. P2X receptor immunoreactivity in the male genital organs of the rat. Cell Tissue Res 300 (2000) 321
7. Obara K., Lepor H., and Walden P.D. Localization of P2Y1 purinoceptor transcripts in the rat penis and urinary bladder. J Urol 160 (1998) 587
8. Gur S., Kadowitz P.J., and Hellstrom W.J. Purinergic (P2) receptor control of lower genitourinary tract function and new avenues for drug action: an overview. Curr Pharm Des 13 (2007) 3236
9. Saenz de Tejada I., Goldstein I., Azadzoi K., Krane R.J., and Cohen R.A. Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med 320 (1989) 1025
10. Rehman J., Chenven E., Brink P., Peterson B., Walcott B., Wen Y.P., et al. Diminished neurogenic but not pharmacological erections in the 2- to 3-month experimentally diabetic F-344 rat. Am J Physiol 272 (1997) H1960
11. Bivalacqua T.J., Kendirci M., Champion H.C., Hellstrom W.J., Andersson K.E., and Hedlund P. Dysregulation of cGMP-dependent protein kinase 1 (PKG-1) impairs erectile function in diabetic rats: influence of in vivo gene therapy of PKG1alpha. BJU Int 99 (2007) 1488
12. Noto T., Inoue H., Mochida H., and Kikkawa K. Role of adenosine and P2 receptors in the penile tumescence in anesthetized dogs. Eur J Pharmacol 425 (2001) 51
13. Rapaport E. Experimental cancer therapy in mice by adenine nucleotides. Eur J Cancer Clin Oncol 24 (1988) 1491
14. Shabbir M., Thompson C., Jarmulowiczc M., Mikhailidis D., and Burnstock G. Effect of extracellular ATP on the growth of hormone-refractory prostate cancer in vivo. BJU Int 102 (2008) 108
15. Agteresch H.J., Burgers S.A., van der Gaast A., Wilson J.H., and Dagnelie P.C. Randomized clinical trial of adenosine 5′-triphosphate on tumor growth and survival in advanced lung cancer patients. Anticancer Drugs 14 (2003) 639
16. Dunn P.M., Zhong Y., and Burnstock G. P2X receptors in peripheral neurons. Prog Neurobiol 65 (2001) 107
17. Angulo J., Cuevas P., Fernández A., Allona A., Moncada I., Martín-Morales A., et al. Enhanced thromboxane receptor-mediated responses and impaired endothelium-dependent relaxation in human corpus cavernosum from diabetic impotent men: role of protein kinase C activity. J Pharmacol Exp Ther 319 (2006) 783
18. Tien X.Y., Brasitus T.A., Kaetzel M.A., Dedman J.R., and Nelson D.J. Activation of the cystic fibrosis transmembrane conductance regulator by cGMP in the human colonic cancer cell line, Caco-2. J Biol Chem 269 (1994) 51
19. Lau D.H., Metcalfe M.J., Mumtaz F.H., Mikhailidis D.P., and Thompson C.S. Purinergic modulation of human corpus cavernosum relaxation. Int J Androl (2007) Epub ahead of print
20. Calvert R.C., Khan M.A., Thompson C.S., Mikhailidis D.P., and Burnstock G. A functional study of purinergic signalling in the normal and pathological rabbit corpus cavernosum. BJU Int 101 (2008) 1043