Assay of salsolinol in peripheral blood mononuclear cells of alcoholics and healthy subjects by gas chromatography-mass spectrometry

Addiction Biology

Volumn 7, Issue 4, 2002, Pages 403-407

  Haber, H ^b   Jahn, H ^a   Ehrenreich, H ^a   Melzig, Matthias F ^c  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CLOMETHIAZOLE; SALSOLINOL;

ADULT; ALCOHOLISM; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIET; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG URINE LEVEL; DRUG WITHDRAWAL; GAS CHROMATOGRAPHY; HUMAN; LYMPHOCYTE; MALE; MASS SPECTROMETRY; MONONUCLEAR CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SOLID PHASE EXTRACTION; THEORY;

ADULT; ALCOHOLISM; BEHAVIOR, ADDICTIVE; BIOLOGICAL MARKERS; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEALTH STATUS; HUMANS; ISOQUINOLINES; LYMPHOCYTES; MALE; TEMPERANCE;

EID: 6444245322     PISSN: 13556215     EISSN: None     Source Type: Journal    
DOI: 10.1080/1355621021000005991     Document Type: Article

References (16)

1. Naoi M, Maruyama W. Cell death of dopamine neuron in aging and Parkinson's diseases. Mech Ageing Dev 1999;111:175-188.
2. Rommelspacher H, Saellstroem-Baum S, Dufeu P, Schmidt LG. Determination of (R)- and (S)-salsolinol sulfate and dopamine sulfate levels in plasma of non-alcoholics and alcoholics. Alcohol 1995;12:309-315.
3. Faraj BA, Camp VM, Davis DC, Lenton JD, Kutner M. Elevation of plasma salsolinol sulfate in chronic alcoholics as compared to non-alcoholics. Alcohol Clin Exp Res 1989;13:155-163.
4. Collins MA, NijmWP, Borge GF, Teas G, Goldfarb C. Dopamine-related tetrahydroisoquinoline: Significant urinary excretion by alcoholics after alcohol consumption. Science 1979;206:1184-1186.
5. Adachi J, Mizoi Y, Fukunaga T et al. Individual differences in urinary excretion of salsolinol in alcoholic patients. Alcohol 1986;3:371-375.
6. Adachi J, Mizoi Y, Fukunaga T, Kogame M, Ninomiya I, Naito, T. Effect of acetaldehyde on urinary salsolinol in healthy man after ethanol intake. Alcohol 1986;3:215-220.
7. Haber H, Winkler A, Putscher I et al. Plasma and urine salsolinol in humans: Effect of acute ethanol intake on the enantiomeric composition of salsolinol. Alcohol Clin Exp Res 1996;20:87-92.
8. Hirst M, Evans DR, Gowdey CW, Adams MA. The influences of ethanol and other factors on the excretion of urinary salsolinol in social drinkers. Pharmacol Biochem Behav 1985;22:993-1000.
9. Riggin RM, McCarthy MJ, Kissinger PT. Identification of salsolinol as a major dopamine metabolite in the banana. J Agric Food Chem 1976;24:189-191.
10. Melzig MF, Putscher I, Henklein P, Haber H. In vitro pharmacological activity of the tetrahydroiso-quinoline salsolinol present in products from Theobroma cacao L. like cocoa and chocolate. J Ethnopharmacol 2000;73:153-159.
11. Haber H, Stender N, Mangholz A, Ehrenreich H, Melzig MF. Quantitative determination of endogenous tetrahydroisoquinoline salsolinol in peripheral blood mononuclear cells by gas chromatography-mass spectrometry. J Chromatogr 1999;B735:299-303.
12. Geigy C. Scientific Tables. Leutner, editor. Novartis Medical Education 1986;3:205-207.
13. Haber H, Putscher I, Fickel J, SchuemannM, Melzig MF. Easy preparation of R(+)- and S(-)-salsolinol of high optical purity. Pharmazie 1993;48:700-702.
14. Haber H, Haber HM, Melzig MF. A new rapid method for the analysis of catecholic tetrahydroisoquinolines by gas chromatography/mass spectrometry. Anal Biochem 1995;224:256-262.
15. Haber H, Dumaual N, Bare DJ et al. The quantitative determination of R- and S-salsolinol in the striatum and adrenal gland of rats selectively bred for disparate alcohol drinking. Addict Biol 1999;4:181-189.
16. Sokoloff P, Schwartz JC. Novel dopamine recepors half a decade later. TIPS 1995;16:270-275.