Mifepristone does not induce cervical softening in non-pregnant women

Human Reproduction

Volumn 19, Issue 10, 2004, Pages 2372-2376

  Ben Chetrit, Avraham ^a   Eldar Geva, Talia ^a   Lindenberg, Tzina ^a   Farhat, Morshed ^a   Shimonovitz, Shlomo ^a   Zacut, David ^a   Gelber, Hadassa ^a   Sitruk Ware, Regine ^b   Spitz, Irving M ^a  

^a SHAARE ZEDEK MEDICAL CENTER   (Israel)

^b POPULATION COUNCIL   (United States)

Author keywords

Mifepristone; Office hysteroscopy; Pain scale; RU 486

Indexed keywords

ANTIGESTAGEN; MIFEPRISTONE; PLACEBO; PROGESTERONE;

ADULT; ANAMNESIS; ARTICLE; BLOOD ANALYSIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MECHANISM; FEMALE; FUNCTION TEST; HUMAN; HYSTEROSCOPY; PAIN ASSESSMENT; PHYSICAL EXAMINATION; PREGNANCY; PROGESTERONE BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; UTERINE CERVIX DILATATION; UTERINE CERVIX RIPENING; UTERUS RELAXATION; VISUAL ANALOG SCALE;

EID: 6444240247     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/deh420     Document Type: Article

References (26)

1. Ashok PW and Templeton A (1999) Nonsurgical mid-trimester termination of pregnancy: a review of 500 consecutive cases. Br J Obstet Gynaecol 106,706-710.
2. Ashok PW, Flett GMM and Templeton A (2000) Mifepristone versus vaginally administered misoprostol for cervical priming before first-trimester termination of pregnancy: a randomized, controlled study. Am J Obstet Gynecol 183,998-1002.
3. Cabrol D, Dubois C, Cronje H, Gonnet JM, Guillot M, Maria B, Moodley J, Oury JF, Thoulon JM, Treisser A et al. (1990) Induction of labor with mifepristone (RU 486) in intrauterine fetal death. Am J Obstet Gynecol 163,540-542.
4. Csapo AI and Pulkkinen MO (1978) Indispensability of the human corpus luteum in the maintenance of early pregnancy: lutectomy evidence. Obstet Gynecol Surv 33,69-71.
5. Chapman CR, Casey KL, Dubner R, Foley KM, Gracely RH and Reading AE (1985) Pain measurement: an overview. Pain 22,1-31.
6. Christin-Maitre S, Bouchard P and Spitz IM (2000) Medical termination of pregnancy. N Engl J Med 342,946-956.
7. Creinin MD, Pymar HC and Schwartz JL (2001a) Mifepristone 100mg in abortion regimens. Obstet Gynecol 99,434-439.
8. Creinin MD, Schwartz JL, Pymar HC and Fink W (2001b) Efficacy of mifepristone followed on the same day by misoprostol for early termination of pregnancy: report of a randomized trial. Br J Obstet Gynaecol 108, 469-473.
9. DeLoach LJ, Higgins MS, Caplan AB and Stiff JL (1998) The visual analog scale in the immediate postoperative period: intra subject variability and correlation with a numeric scale. Anesth Analg 86,102-106.
10. Durlot F, Dubois C, Brunerie J and Frydman R (1988) Efficacy of progesterone antagonist Ru486 for pre-operative cervical dilatation during first trimester abortion. Hum Reprod 3,583-584.
11. Embrey MP and Tait T (1977) Ripening of the cervix with extra-ammotic prostaglandin E2 in viscous gel before induction of labour. Br J Obstet Gynaecol 44,264-268.
12. Facchinetti F, Piccinini F and Volpe A (2000) Chemical ripening of the cervix with intracervical application of sodium nitroprusside: a randomized controlled trial. Hum Reprod 15,2224-2227.
13. Fox MC, Creinin MD and Harwood B (2002) Mifepristone and vaginal misoprostol on the same day for abortion from 50 to 63 days' gestation. Contraception 66,225-229.
14. Gordon AJ and Calder AA (1978) Oestradiol applied locally to ripen the unfavourable cervix. Lancet ii,1319-1321.
15. Gupta JK and Johnson N (1990) Effect of mifepristone on dilatation of the pregnant and non-pregnant cervix. Lancet 335,1238-1240.
16. Jannet D, Aflak N, Abankwa A, Carbonne B, Marpeau L and Milliez J (1996) Termination of 2nd and 3rd trimester pregnancies with mifepristone and misoprostol. Eur J Obstet Gynecol Reprod Biol 70,159-163.
17. Johnson N (1989) Intracervical tents: usage and mode of action. Obstet Gynecol Surv 44,410-420.
18. Lefebvre Y, Proulx L, Elie R, Poulin O and Lanza E (1990) The effects of RU486 on cervical ripening. Am J Obstet Gynecol 162,61-65.
19. MacKenzie IZ and Embrey MP (1977) Cervical ripening with intravaginal PG E2 gel. Br Med J ii,1381-1384.
20. MacLennan AH, Green RC, Bryant-Greenwood GD, Greenwood FC and Seamark RF (1980) Ripening of the human cervix and induction of labour with purified porcine relaxin. Lancet i,220-223.
21. Ohnhaus EE and Adler R (1975) Methodological problems in the measurement of pain: a comparison between the verbal rating scale and the visual analog scale. Pain 1,379-384.
22. Piccinini F, Fano A, Volpe A and Facchinetti F (2003) Ripening of the cervix with sodium nitroprusside in nonpregnant women. J Soc Gynecol Invest 10,438-442.
23. Pymar HC, Creinin MD and Schwartz JL (2001) Mifepristone followed on the same day by vaginal misoprostol for early abortion. Contraception 64, 87-92.
24. Schaff EA, Fielding SL, Westhoff C, Ellertson C, Eisinger SH, Stadalius LS and Fuller L (2000) Vaginal misoprostol administered 1, 2, or 3 days after mifepristone for early medical abortion: a randomized trial. J Am Med Assoc 284,1948-1953.
25. Snijders MP, deGoeij AF, Debets-Te Baerts MJ, Rousch MJ, Koudstaal J and Bosman FT (1992) Imummocytochemical analysis of oestrogen receptors and progesterone receptors in the human uterus throughout the menstrual cycle and after the menopause. J Reprod Fertil 94,363-371.
26. Stjernholm Y, Sahlin L, Akerberg S, Elinder A, Eriksson HA, Malmstrom A and Ekman G (1996) Cervical ripening in humans: potential roles of estrogen, progesterone, and insulin-like growth factor-I. Am J Obstet Gynecol 174,1065-1071.