Complete replacement of H2 by D2 via Pd/C-catalyzed H/D exchange reaction

Organic Letters

Volumn 6, Issue 20, 2004, Pages 3521-3523

  Sajiki, Hironao ^a   Kurita, Takanori ^a   Esaki, Hiroyoshi ^a   Aoki, Fumiyo ^a   Maegawa, Tomohiro ^a   Hirota, Kosaku ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; DEUTERIUM; HYDROGEN; PALLADIUM;

ARTICLE; CATALYSIS; CATALYST; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; GAS; REACTION ANALYSIS; STRUCTURE ANALYSIS;

EID: 6444239974     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol048591b     Document Type: Article

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36. 2O has often been observed during catalytic hydrogenation while the degrees of exchange efficiency are not so high. For example: (a) Schrock, R. R.; Osborn, J. A. Chem. Commun. 1970, 567-568. (b) Schrock, R. R.; Osborn, J. A. J. A. Chem. Soc. 1976, 98, 2134-2143. (c) Kubas, G. J.; Burns, C. J.; Khalsa, G. R. K.; van der Sluys, L. S.; Kiss, G.; Hoff, C. D. Organometallics 1992, 11, 3390-3404. (d) Chan, L.; Leung, Y. S. J. Organomet. Chem. 1994, 464, 103-106.
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38. 1H NMR after the conversion of the carboxylic acid into corresponding methyl ester on the basis of the integration of the methyl protons.