The inhibition of aortic smooth muscle cell proliferation by the intravenous anesthetic ketamine

Anesthesia and Analgesia

Volumn 99, Issue 5, 2004, Pages 1408-1412

  Shiga, Yousuke ^a   Minami, Kouichiro ^a,d   Segawa, Kayoko ^b   Uezono, Yasuhito ^c   Shiraishi, Munehiro ^a   Sata, Takeyoshi ^a   Yamamoto, Chieko ^b   Sung Teh, Kim ^b  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b Kitakyushu Institute of Biophysics   (Japan)

^c NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^d UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; FENTANYL; KETAMINE; KT 5823; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROPOFOL; PROTEIN KINASE C INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA MEDIA; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROSCLEROSIS; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HYPERTENSION; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR DISEASE;

ANESTHETICS, DISSOCIATIVE; ANESTHETICS, INTRAVENOUS; ANIMALS; AORTA; BALLOON DILATATION; CELL COUNT; CELL PROLIFERATION; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC GMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; FENTANYL; HUMANS; KETAMINE; MUSCLE, SMOOTH, VASCULAR; PROPOFOL; PROTEIN KINASE C; RATS; THYMIDINE; TUNICA INTIMA;

EID: 6444233482     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000132977.84091.B5     Document Type: Article

References (14)

1. Ross R. The pathogenesis of atherosclerosis: an update. N Engl J Med 1986;314:488-500.
2. Schwartz SM, Campbell GR, Campbell JH. Replication of smooth muscle cells in vascular disease. Circ Res 1986;58: 427-44.
3. Jimi N, Segawa K, Minami K, et al. Inhibitory effect of the intravenous anesthetic ketamine on rat mesangial cell proliferation. Anesth Analg 1997;84:190-5.
4. Clowes AW, Reidy MA, Clowes MM. Kinetics of cellular proliferation after arterial injury, I: smooth muscle growth in the absence of endothelium. Lab Invest 1983;49:327-33.
5. Toullec D, Pianetti P, Coste H, et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 1991;266:15771-81.
6. Chijiwa T, Mishima A, Hagiwara M, et al. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino) ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem 1990;265:5267-72.
7. Kase H, Iwahashi K, Nakanishi S, et al. K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem Biophys Res Commun 1987;142:436-40.
8. Kharasch ED. Pharmacokinetics of ketamine. In Bowdle TA, Horita A, Kharasch ED, eds. The pharmacologic basis of anesthesiology. New York: Churchill Livingstone, 1995:357-73.
9. Wieber J, Gugler R, Hengstmann JH, Dengler HJ. Pharmacokinetics of ketamine in man. Anaesthesist 1975;24:260-3.
10. Idvall J, Ahlgren I, Aronsen KR, Stenberg P. Ketamine infusions: pharmacokinetics and clinical effects. Br J Anaesth 1979;51: 1167-73.
11. Kudoh A, Kudoh E, Katagai H, Takazawa T. Ketamine suppresses norepinephrine-induced inositol 1,4,5-trisphosphate formation via pathways involving protein kinase C. Anesth Analg 2002;94:552-7.
12. Okamoto T, Minami K, Uezono Y, et al. The inhibitory effects of ketamine and pentobarbital on substance p receptors expressed in Xenopus oocytes. Anesth Analg 2003;97:104-10.
13. Minami K, Minami M, Harris RA. Inhibition of 5-hydroxytryptamine type 2A receptor-induced currents by n-alcohols and anesthetics. J Pharmacol Exp Ther 1997;281:1136-43.
14. Bowdle TA, Radant AD, Cowley DS, et al. Psychedelic effects of ketamine in healthy volunteers: relationship to steady-state plasma concentrations. Anesthesiology 1998;88:82-8.