Intramolecular carbolithiation reactions for the synthesis of 2,4-disubstituted tetrahydro-quinolines: Evaluation of TMEDA and (-)-sparteine as ligands in the stereoselectivity

Organic Letters

Volumn 11, Issue 6, 2009, Pages 1237-1240

  Martínez Estíbalez, Unai ^a   Sotomayor, Nuria ^a   Lete, Esther ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

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Indexed keywords

EID: 64349122907     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol900066c     Document Type: Article

References (67)

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65. The enantiomeric excess for each diastereomer was determined by comparison with the racemic mixture in all cases by CSP HPLC
66. (Chirlacel OJ, 2% hexane/i-propanol). See Supporting Information.
67. The absolute configuration of each diastereomer was assigned by comparison with the results obtained performing the carbolithiation reaction with a substrate that incorporates a (R) - (-) -4-phenyl-2-oxazolidinone as chiral auxiliary. See Supporting Information.