Lansoprazole in globus pharyngeus: Double-blind, randomized, placebo-controlled trial

Journal of Otolaryngology - Head and Neck Surgery

Volumn 37, Issue 5, 2008, Pages 657-663

  Dumper, Jaymi ^a   Mechor, Brad ^a   Chau, Jason ^a   Allegretto, Michael ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF ALBERTA HOSPITAL   (Canada)

Author keywords

Glasgow edinburgh throat scale; Globus pharyngeus; Laryngopharyngeal reflux; Proton pump inhibitors; Randomized controlled trial

Indexed keywords

LANSOPRAZOLE; PLACEBO;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; GASTROESOPHAGEAL REFLUX; GLOBUS PHARYNGEUS; HUMAN; MALE; PRIORITY JOURNAL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SEX RATIO; THROAT DISEASE;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ADULT; AMBULATORY CARE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; MALE; MIDDLE AGED; PATIENT SATISFACTION; PHARYNGEAL DISEASES; PHARYNX; PROBABILITY; PROSPECTIVE STUDIES; QUALITY OF LIFE; REFERENCE VALUES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 64349103221     PISSN: 19160216     EISSN: None     Source Type: Journal    
DOI: 10.2310/7070.2008.0107     Document Type: Article

References (34)

1. Moloy PJ, Narula A. The globus symptom. Arch Otolaryngol 1987; 108:740-4.
2. Purcell J. A treatise of vapours or hysterick fits. 2nd ed. London: Edward Place; 1707.
3. Malcomson KG. Globus hystericus vel pharynges. J Laryngol Otol 1968;82:219-30.
4. Belafsky PC. Abnormal endoscopic pharyngeal and laryngeal findings attributable to reflux. Am J Med 2003;115:90S-6S.
5. Chevalier JM, Brossard E, Monnier P. Globus sensation and gastroesophageal reflux. Eur Arch Otorhinolaryngol 2003;260:273-6.
6. Smit CF, Van Leeuwen J, Mathus-Vliegen L, et al. Gastropharyngeal and gastroesophageal reflux in globus and hoarseness. Arch Otol Head Neck Surg 2000;126:827-30.
7. Ahmed T, Ableson T, Hicks DM, et al. Chronic laryngitis associated with GERD: a large scale prospective assessment of differences in practice patterns between gastroenterologists and ENT physicians. Gastroenterology 2005;128:M1769.
8. Noordzij JP, Khidr A, Desper E, et al. Correlation of pH probe-measured laryngopharyngeal reflux with symptoms and signs of reflux laryngitis. Laryngoscope 2002;112:2192-5.
9. Qadeer MA, Swoger J, Milstein C, et al. Correlation between symptoms and laryngeal signs in laryngopharyngeal reflux. Laryngoscope 2005;115:1947-52.
10. Hicks DM, Ours TM, Abelson TI, et al. The prevalence of hypopharynx findings associated with gastroesophageal reflux in normal volunteers. J Voice 2002;16:564-79.
11. Milstein C, Charbel S, Hicks DM, et al. Prevalence of laryngeal irritation signs associated with reflux in asymptomatic volunteers: impact of endoscopic technique (rigid vs. flexible scope). Laryngoscope 2005;115:2256-61.
12. Branski RC, Bhattacharyya N, Shapiro J. The reliability of the assessment of endoscopic laryngeal findings associated with laryngopharyngeal reflux disease. Laryngoscope 2002;112:1019-24.
13. Tutuian R, Castell DO. Diagnosis of laryngopharyngeal reflux. Curr Opin Otolaryngol Head Neck Surg 2004;12:174-9.
14. Belafsky PC, Postma GN, Koufman JA. Laryngopharyngeal reflux symptoms improve before changes in physical findings. Laryngoscope 2001;111:979-81.
15. Yorulmaz I, Ozlugedik S, Kucuk B. Gastroesophageal reflux disease: symptoms versus pH monitoring results. Otolaryngol Head Neck Surg 2003;129:582-6.
16. Cool M, Poelmans J, Feenstra L, et al. Characteristics and clinical relevance of proximal esophageal pH monitoring. Am J Gastroenterol 2004;99:2317-23.
17. Oelschlager BK, Chang L, Pope CE II, et al. Typical GERD symptoms and esophageal pH monitoring are not enough to diagnose pharyngeal reflux. J Surg Res 2005;128:55-60.
18. Koufman JA, Aviv JE, Casiano RR, et al. Laryngopharyngeal reflux: position statement of the Committee on Speech, Voice, and Swallowing Disorders of the American Academy of Otolaryngology-Head and Neck Surgery. Otolaryngol Head Neck Surg 2002;127:32-5.
19. Moraes-Filho JPP, Cecconello I, Gama-Rodrigues J, et al. Brazilian consensus on gastroesophageal reflux disease: proposals for assessment, classification, and management. Am J Gastroenterol 2002;97:241-8.
20. Merati AL, Lim HJ, Ulualp SO, et al. Meta-analysis of upper probe measurements in normal subjects and patients with laryngopharyngeal reflux. Ann Otol Rhinol Laryngol 2005;114:177-82.
21. Kendall KA. Controversies in the diagnosis and management of laryngopharyngeal reflux disease. Curr Opin Otolaryngol Head Neck Surg 2006;14:113-4.
22. Modlin IM, Sachs G, editors. Inhibition of the gastric acid pump. In: Acid related diseases: biology and treatment. Konstanz, Germany: Schnetztor-Verlag GmbH D-Konstanz; 1998. p. 126-45.
23. Sachs G, Prinz C, Loo D, et al. Gastric acid secretion: activation and inhibition. Yale J Biol Med 1994;67:81-95.
24. Huber R, Kohl B, Sachs G, et al. Review article: the continuing development of proton pump inhibitors with particular reference to pantoprazole. Aliment Pharmacol Ther 1995;9:363-78.
25. Noordzij JP, Khidr A, Evans BA, et al. Evaluation of omeprazole in the treatment of reflex laryngitis: a prospective, placebo-controlled, randomized, double-blind study. Laryngoscope 2001; 111:2147-51.
26. Ehrer AJ, Habermann W, Hammer HF, et al. Effect of pantoprazole on the course of reflux associated laryngitis: a placebo-controlled double-blind crossover study. Scand J Gastroenterol 2003;38:462-7.
27. Vaezi MF, Richter JE, Stasney CR, et al. Treatment of chronic posterior laryngitis with esomeprazole. Laryngoscope 2006;116: 254-60.
28. Kuipers EJ. Proton pump inhibitors and gastric neoplasia. Gut 2006;55:1217-21.
29. Yearsley KA, Gilby LJ, Ramadas AV, et al. Proton pump inhibitor therapy is a risk factor for Clostridium difficile-associated diarrhoea. Aliment Pharmacol Ther 2006;24:613-9.
30. Deary IJ, Wilson JA, Harris MB, et al. Globus pharyngeus: development of a symptom assessment scale. J Psychosom Res 1995;39:203-13.
31. Juniper EF, Guyatt GH, Willam A, et al. Determining a minimal important change in a disease-specific quality oflife questionnaire. J Clin Epidemiol 1994;47:85-7.
32. Harar RP, Kumar S, Saeed MA, et al. Management of globus pharyngeus: review of 699 cases. J Laryngol Otol 2004;118:522-7.
33. Sen P, Georgalas C, Bhattacharyya AK. A systematic review of the role of proton pump inhibitors for symptoms of laryngopharyngeal reflux. Clin Otolaryngol 2006;31:20-4.
34. Park W, Hicks DM, Khandwala F, et al. Laryngopharyngeal reflux: prospective cohort study evaluating optimal dose of proton-pump inhibitor therapy and pretherapy predictors of response. Laryngoscope 2005;115:1230-8.