New Labdane diterpenes as intestinal α-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 9, 2009, Pages 2562-2565

  Prabhakar Reddy, P ^a   Tiwari, Ashok K ^a   Ranga Rao, R ^a   Madhusudhana, K ^a   Rama Subba Rao, V ^a   Ali, Amtul Z ^a   Suresh Babu, K ^a   Madhusudana Rao, J ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Glucosidase inhibitory activity; Antihyperglycemic activity; Hedychium spicatum; Labdane type diterpenes; Spicatanol; Spicatanol methyl ether

Indexed keywords

ALPHA GLUCOSIDASE; ALPHA GLUCOSIDASE INHIBITOR; ANTIDIABETIC AGENT; HEDYCHIUM SPICATUM EXTRACT; INTESTINE ENZYME; LABDANE DITERPENE; PLANT EXTRACT; TERPENOID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ISOLATION; DRUG MECHANISM; ENZYME INHIBITION; HEDYCHIUM SPICATUM; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HYPERGLYCEMIA; INFRARED SPECTROMETRY; MALE; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHYTOCHEMISTRY; POSTPRANDIAL STATE; RAT; RHIZOME; STRUCTURE ACTIVITY RELATION;

ALPHA-GLUCOSIDASES; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; HYPOGLYCEMIC AGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, WISTAR; RHIZOME; ZINGIBERACEAE;

HEDYCHIUM SPICATUM;

EID: 64249171799     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.045     Document Type: Article

References (24)

1. The Wealth of India. 1959; Vol. V, p. 13. C.S.I.R., New Delhi.
2. Chopra, R. N.; Nayar, S. L.; Chopra, I. C. Glossary of Indian Medicinal Plant 1956, C.S.I.R, New Delhi.
3. Tandon S.K., Chandra S., Gupta S., and Lal J. Indian J. Pharm. Sci. 59 (1997) 148
4. Srimal R.C., Sharma S.C., and Tandon J.S. Indian J. Pharmacol. 16 (1984) 143
5. Jinga P., Nehal K., and Sumitra C. Indian J. Pharm. Sci. 68 (2006) 882
6. Jadhav V., Kore A., and Kadam V.J. Fitoterapia 78 (2007) 470
7. Dixit V.K., and Varma K.C. Indian J. Pharmacol. 2 (1979) 147
8. Akhtar M.S., Iqbal Z., Khan M.N., and Lateef M. Small Ruminant Res. 38 (2000) 99
9. Sharma P.V. Classical Uses of Medicinal Plants. First ed. (1996), Chaukhambha Vishvabharati (Oriental Publisher and Distributors), Varanasi (India) p 353
10. Carroll M.F., Gutierrez A., Castro M., Tsewang D., and Schade D.S. J. Clin. Endocrinol. Metab. 88 (2003) 5248
11. Gerich J.E. Arch. Intern. Med. 163 (2003) 1306
12. Slama G., Elgrably F., Sola A., Mbemba J., and Larger E. Diabetes Metab. 32 (2006) 187
13. Hanefeld M., and Schaper F. Expert Rev. Cardiovasc. Ther. 6 (2008) 153
14. Tiwari A.K., Kumbhare R.M., Agawane S.B., Ali A.Z., and Kumar K.V. Bioorg. Med. Chem. Lett. 18 (2008) 4130
15. Rao A.S., Srinivas P.V., Tiwari A.K., Vanka U.M.S., Rao R.V.S., Dasari K.R., and Rao J.M. J. Chromatogr., B 855 (2007) 166
16. 4, 331.1909).
17. Zou C., Zhao Q., Hao X., Chen Y., and Hong X. Acta Bota. Yunnica 21 (1999) 253
18. 4, 345.2066).
19. Sharma S.C., and Tandon J.S. Indian J. Chem. (B) 22 (1983) 93
20. Sharma S.C., Tandon J.S., Uprety H., Shukla Y.N., and Dhar M.M. Phytochemistry 14 (1975) 1059
21. Sharma S.C., Tandon J.S., and Dhar M.M. Phytochemistry 15 (1976) 827
22. Weyerstahl P., Schwieger R., Schwope I., and Hashem Md.A. Liebigs Annalen 7 (1995) 1389
23. Matsuda H., Morikawa T., Sakamoto Y., and Toguchida I. Bioorg. Med. Chem. 10 (2002) 2527
24. Gloster T.M., Meloncelli P., Stick R.V., Zechel D., Vasella A., and Davies G.J. J. Am. Chem. Soc. 129 (2007) 2345