Clinical evidence for immunomodulation induced by high-dose melphalan and autologous blood stem cell transplantation as cause for complete clinical remission of multiple myeloma-associated cryoglobulin-vasculitis

International Journal of Hematology

Volumn 88, Issue 4, 2008, Pages 454-456

  Hillengass, J ^a   Ho, A D ^a   Goldschmidt, H ^a   Waldherr, R ^b   Moehler, T M ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b Gemeinschaftspraxis fur Pathologie   (Germany)

Author keywords

Cryoglobulinemia; Immune reset; Multiple myeloma; Stem cell transplantation

Indexed keywords

CORTICOSTEROID; CRYOGLOBULIN; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DOXORUBICIN; GRANULOCYTE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN KAPPA CHAIN; MELPHALAN; PREDNISOLONE; PREDNISONE; RITUXIMAB; ALKYLATING AGENT;

ADULT; ANKLE; ARTICLE; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; CANCER CHEMOTHERAPY; CANCER REGRESSION; CANCER STAGING; CASE REPORT; CRYOGLOBULINEMIA; CYTOPENIA; DRUG DOSE REDUCTION; DRUG MEGADOSE; FOOT; GLOMERULONEPHRITIS; HUMAN; HUMAN TISSUE; IMMUNOMODULATION; KIDNEY BIOPSY; KNEE; MALE; MULTIPLE CYCLE TREATMENT; MULTIPLE MYELOMA; PLASMAPHERESIS; PNEUMONIA; PROTEINURIA; SEPSIS; SKIN DEFECT; TOE; VASCULITIS; AUTOTRANSPLANTATION; IMMUNOLOGY; MIDDLE AGED; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION;

ANTINEOPLASTIC AGENTS, ALKYLATING; CRYOGLOBULINS; HUMANS; MALE; MELPHALAN; MIDDLE AGED; MULTIPLE MYELOMA; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; TRANSPLANTATION, AUTOLOGOUS; VASCULITIS;

EID: 64249161229     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12185-008-0177-1     Document Type: Article

References (12)

1. IB Bayer-Garner BR Smoller 2003 Leukocytoclastic (small vessel) vasculitis in multiple myeloma Clin Exp Dermatol 28 5 521 4 10.1046/j.1365-2230. 2003.01324.x
2. JM van Laar A Tyndall 2006 Adult stem cells in the treatment of autoimmune diseases Rheumatology (Oxford) 45 10 1187 93 10.1093/rheumatology/ kel158
3. E Roux F Dumont-Girard M Starobinski CA Siegrist C Helg B Chapuis 2000 Recovery of immune reactivity after T-cell-depleted bone marrow transplantation depends on thymic activity Blood 96 6 2299 303
4. NM Wulffraat KI de B Prakken 2006 Refractory juvenile idiopathic arthritis: using autologous stem cell transplantation as a treatment strategy Expert Rev Mol Med 8 26 1 11 10.1017/S1462399406000135
5. JC Edwards L Szczepanski J Szechinski A Filipowicz-Sosnowska P Emery DR Close 2004 Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis N Engl J Med 350 25 2572 81 10.1056/NEJMoa032534
6. PA Muraro DC Douek A Packer K Chung FJ Guenaga R Cassiani-Ingoni 2005 Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients J Exp Med 201 5 805 16 10.1084/jem.20041679
7. A Tyndall R Saccardi 2005 Haematopoietic stem cell transplantation in the treatment of severe autoimmune disease: results from phase I/II studies, prospective randomized trials and future directions Clin Exp Immunol 141 1 1 9 10.1111/j.1365-2249.2005.02806.x
8. G D'Amico 1998 Renal involvement in hepatitis C infection: cryoglobulinemic glomerulonephritis Kidney Int 54 2 650 71 10.1046/j.1523-1755. 1998.00028.x
9. V Agnello 1997 The etiology and pathophysiology of mixed cryoglobulinemia secondary to hepatitis C virus infection Springer Semin Immunopathol 19 1 111 29 10.1007/BF00945029
10. A Gause P Lamprecht 2003 Cryoglobulinemic vasculitis Internist (Berl) 44 2 165 74
11. F Lunel L Musset P Cacoub L Frangeul P Cresta M Perrin 1994 Cryoglobulinemia in chronic liver diseases: role of hepatitis C virus and liver damage Gastroenterology 106 5 1291 300
12. LE Adinolfi R Utili V Attanasio R Zampino E Ragone MF Tripodi 1996 Epidemiology, clinical spectrum and prognostic value of mixed cryoglobulinaemia in hepatitis C virus patients: a prospective study Ital J Gastroenterol 28 1 1 9