Consequences of major bleeding in hospitalized patients with non-ST segment elevation acute coronary syndromes receiving injectable anticoagulants

Current Medical Research and Opinion

Volumn 25, Issue 2, 2009, Pages 413-420

  Happe, Laura E ^a   Rao, Sunil V ^b,c   Horblyuk, Ruslan ^d   Franklin, Meg ^a   Lunacsek, Orsolya E ^a   Menditto, Laura ^d  

^a XCENDA   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c DURHAM VA MEDICAL CENTER   (United States)

^d GLAXOSMITHKLINE   (United States)

Author keywords

Anticoagulants; Major bleed; Resource utilization; Unstable angina NSTEMI

Indexed keywords

ANTICOAGULANT AGENT; DALTEPARIN; ENOXAPARIN; FONDAPARINUX; HEPARIN;

ACUTE CORONARY SYNDROME; ADULT; AGE DISTRIBUTION; AGED; ANTICOAGULANT THERAPY; BLEEDING; BRAIN HEMORRHAGE; COHORT ANALYSIS; CONFERENCE PAPER; COVARIANCE; FEMALE; HEMOPERITONEUM; HOSPITAL CARE; HOSPITAL READMISSION; HOSPITALIZATION; HOSPITALIZATION COST; HUMAN; INTERNATIONAL CLASSIFICATION OF DISEASES; LENGTH OF STAY; LIVER DISEASE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MORTALITY; OUTCOME ASSESSMENT; PEPTIC ULCER; RETROSPECTIVE STUDY; RISK FACTOR; ST SEGMENT ELEVATION; STATISTICAL MODEL; SUBARACHNOID HEMORRHAGE; THROMBOCYTOPENIA; UNSTABLE ANGINA PECTORIS; ADOLESCENT; ARTICLE; MIDDLE AGED;

ACUTE CORONARY SYNDROME; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTICOAGULANTS; FEMALE; HEMORRHAGE; HOSPITALIZATION; HUMANS; LENGTH OF STAY; MALE; MIDDLE AGED; RISK FACTORS;

EID: 64249159808     PISSN: 03007995     EISSN: 14734877     Source Type: Journal    
DOI: 10.1185/03007990802649133     Document Type: Conference Paper

References (23)

1. Savonitto S, Ardissino D, Granger CB, et al. Prognostic value of the admission electrocardiogram in acute coronary syndromes. JAMA 1999;281:707-713 (Pubitemid 29113451)
2. Harrington RA, Becker RC, Cannon CP, et al. American College of Antithrombotic therapy for non-ST-segment elevation acute coronary syndromes: American College of Chest Physicians evidence- based clinical practice guidelines (8th Edition). Chest 2008;133:670-707 (Pubitemid 351892975)
3. Schulman S, Beyth RJ, Kearon C, et al. Hemorrhagic complications of anticoagulant and thrombolytic treatment: American College of Chest Physicians evidence-based clinical practice guidelines (8th Edition). Chest 2008;133:257-298 (Pubitemid 351892969)
4. Yusuf S, Mehta SR, Chrolavicius S, et al. Comparison of fondaparinux and enoxaparin in acute coronary syndromes. N Engl J Med 2006;354:1464-1476
5. Magee KD, Sevcik W, Moher D, et al. Low molecular weight heparins versus unfractionated heparin for acute coronary syndromes. Cochrane Database Syst Rev 2003; CD002132
6. Fifth Organization to Assess Strategies in Acute Ischemic Syndromes (OASIS-5) InvestigatorsComparison of fondaparinux and enoxaparin in acute coronary syndromes. N Engl J Med 2006;354:1464-1476
7. Eikelboom JW, Mehta SR, Anand SS, et al. Adverse impact of bleeding on prognosis in patients with acute coronary syndromes. Circulation 2006;114:774-782 (Pubitemid 44268228)
8. Rao SV, O'Grady K, Pieper KS, et al. Impact of bleeding severity on clinical outcomes among patients with acute coronary syndromes. Am J Cardiol 2005;96:1200-1206 (Pubitemid 41505393)
9. Manoukian SV, Feit F, Mehran R, et al. Impact of major bleeding on 30-day mortality and clinical outcomes in patients with acute coronary syndromes: an analysis from the ACUITY trial. J Am Coll Cardiol 2007;49:1362-1368 (Pubitemid 46476844)
10. Rao SV, Kaul PR, Liao L, et al. Association between bleeding, blood transfusion, and costs among patients with non-ST-segment elevation acute coronary syndromes. Am Heart J 2008; 155:369-374
11. Hutten BA, Lensing AW, Kraaijenhagen RA, et al. Safety of treatment with oral anticoagulants in the elderly: a systematic review. Drugs Aging 1999;14:303-312 (Pubitemid 29195346)
12. Pengo V, Legnani C, Noventa F, et al. Oral anticoagulant therapy in patients with nonrheumatic atrial fibrillation and risk of bleeding. Thromb Haemost 2001;85:418
13. Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987;40:373-383 (Pubitemid 17055592)
14. Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992;45:613-619
15. Collet JP, Montalescot G, Fine E, et al. Enoxaparin in unstable angina patients who would have been excluded from randomized pivotal trials. J Am Coll Cardiol 2003;41:8-14 (Pubitemid 36044396)
16. Rao SV, Eikelboom JA, Granger CB, et al. Bleeding and blood transfusion issues in patients with non-ST-segment elevation acute coronary syndromes. Eur Heart J 2007;28:1193-1204 (Pubitemid 47343833)
17. Kugelmass AD, Cohen DJ, Brown PP, et al. Hospital resources consumed in treating complications associated with percutaneous coronary interventions. Am J Cardiol 2006;97:322-327 (Pubitemid 43133043)
18. Fox KA, Steg PG, Eagle KA, et al. Decline in rates of death and heart failure in acute coronary syndromes, 1999-2006. JAMA 2007;297:1892-1900
19. Stone GW, McLaurin BT, Cox DA, et al.; ACUITY Investigators. Bivalirudin for patients with acute coronary syndromes. New Engl J Med 2006;355:2203-2216
20. Shorr A, Kwong L, Sarnes M, et al. Venous thromboembolism after orthopedic surgery: implications of the choice for prophylaxis. Thromb Res 2007;121:17-24 (Pubitemid 350025996)
21. Shorr A, Sarnes M, Peeples P, et al. Cost implications of injectable anticoagulant choice for thromboprophylaxis following orthopaedic surgery. Am J Health Syst Pharm 2007;64:2349-2355 (Pubitemid 350174706)
22. Shorr AF, Nutescu E, Farrelly E, et al. Postdischarge oral versus injectable anticoagulation following major orthopedic surgery. Ann Pharmacother 2008;42:1216-1221
23. Kwong LM, Happe LE, Horblyuk R, et al. Decreased venous thromboembolism with injectable vs oral anticoagulation following discharge for major orthopaedic surgery. J Arthroplasty. 2008;23:25-30