Synthesis and characterization of acrylamide/N-vinylpyrrolidone copolymer with pendent thiol groups for ophthalmic applications

Acta Biomaterialia

Volumn 5, Issue 4, 2009, Pages 1056-1063

  Niu, Guoguang ^a   Yang, Ying ^c   Zhang, Hongbin ^a   Yang, Jun ^c   Song, Li ^a   Kashima, Miki ^a   Yang, Zhou ^a   Cao, Hui ^a   Zheng, Yudong ^a   Zhu, Siquan ^b   Yang, Huai ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY BEIJING   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Disulfide bond; Hydrogel; Lens regeneration; Vitreous substance

Indexed keywords

ACRYLIC MONOMERS; AMIDES; COVALENT BONDS; GELATION; PORE SIZE; REFRACTIVE INDEX; SULFUR COMPOUNDS;

ACRYLAMIDES; DISSOLUTION REACTIONS; DISULPHIDE BONDS; INJECTABLES; LENS REGENERATION; N VINYLPYRROLIDONE; REDUCTIVE DISSOLUTION; SYNTHESIS AND CHARACTERIZATIONS; THIOL GROUPS; VITREOUS SUBSTANCE;

HYDROGELS;

ACRYLAMIDE N VINYLPYRROLIDINONE COPOLYMER; COPOLYMER; TISSUE SCAFFOLD; UNCLASSIFIED DRUG;

ARTICLE; DISSOLUTION; GELATION; HYDROGEL; LENS IMPLANT; PARTICLE SIZE; POLYMERIZATION; POROSITY; PRIORITY JOURNAL; REFRACTION INDEX; SYNTHESIS; VITREOUS BODY; WATER CONTENT;

EID: 64249143968     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2008.10.015     Document Type: Article

References (21)

1. Liu H., Li H., Cheng W., Yang Y., Zhu M., and Zhou C. Novel injectable calcium phosphate/chitosan composites for bone substitute materials. Acta Biomater 2 (2006) 557-565
2. Burdick J.A., and Anseth K.S. Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering. Biomaterials 23 22 (2002) 4315-4323
3. Kang G.D., Cheon S.H., Khang G., and Song S.C. Thermosensitive poly(organophosphazene) hydrogels for a controlled drug delivery. Eur J Pharm Biopharm 63 (2006) 340-346
4. Kretlow J.D., Klouda L., and Mikos A.G. Injectable matrices and scaffolds for drug delivery in tissue engineering. Adv Drug Deliv Rev 5 4-5 (2007) 263-273
5. de Groot J.H., van Beijma F.J., Haitjema H.J., Dillingham K.A., Hodd K.A., Koopmans S.A., et al. Injectable intraocular lens materials based upon hydrogels. Biomacromolecules 2 (2001) 628-634
6. Aliyar H.A., Hamilton P.D., and Ravi N. Refilling of ocular lens capsule with copolymeric hydrogel containing reversible disulfide. Biomacromolecules 6 (2005) 204-211
7. Soman N., and Banerjee R. Artificial vitreous replacements. Bio-Med Mater Eng 13 (2003) 59-74
8. Nishi O. Refilling the lens of the rabbit eye after endocapsular cataract surgery. Folia Ophthalmol 38 (1987) 1615-1618
9. Gwon A. Lens regeneration in mammals: a review. Surv Ophthamol 51 (2006) 51-62
10. Rabenstein D.L., and Weaver K.H. Kinetics and equilibria of the thiol/disulfide exchange reactions of somatostatin with glutathione. J Org Chem 61 (1996) 7391-7397
11. Shu X.Z., Liu Y., Luo Y., Roberts M.C., and Prestwich G.D. Disulfide cross-linked hyaluronan hydrogels. Biomacromolecules 3 (2002) 1304-1311
12. Plunkett K.N., Berkowski K.L., and Moore J.S. Chymotrypsin responsive hydrogel: application of a disulfide exchange protocol for the preparation of methacrylamide containing peptides. Biomacromolecules 6 (2005) 632-637
13. Serban M.A., and Prestwich G.D. Synthesis of hyaluronan haloacetates and biology of novel cross-linker-free synthetic extracellular matrix hydrogels. Biomacromolecules 8 9 (2007) 2821-2828
14. Aliyar H.A., Foster W.J., Hamilton P.D., and Ravi N. Towards the development of an artificial human vitreous. Polym Preprints 45 2 (2004) 469-470
15. Hamilton P.D., Aliyar H.A., and Ravi N. Biocompatibility of thiol-containing polyacrylamide polymers suitable for ophthalmic applications. Polym Preprints 45 2 (2004) 495-496
16. Ellman G.L. Tissue sulfhydryl groups. Arch Biochem Biophys 82 (1959) 70-77
17. Pan Z.R. Polymer Chemistry (2002), Chemical Industry Press, Beijing pp. 90-98
18. Hisano N., Morikawa N., Iwata H., and Ikada Y. Entrapment of islets into reversible disulfide hydrogels. J Biomed Mater Res 40 (1998) 115-123
19. Wyszecki G., and Stiles W.S. Color Science (1967), John Wiley & Sons, New York
20. Noell W.K., Walker V.S., and Kang B.S. Retinal damage by light in rats. Invest Ophthalmol 5 (1966) 450-473
21. Lipman R.D., and Taylor A. The in vitro replicative potential and cellular morphology of human lens epithelial cells derived from different aged donors. Curr Eye Res 6 (1987) 1453-1457