Development of CoMFA and CoMSIA models of cytotoxicity data of anti-HIV-1-phenylamino-1H-imidazole derivatives

European Journal of Medicinal Chemistry

Volumn 44, Issue 6, 2009, Pages 2400-2407

  Basu, Arijit ^a   Jasu, Kalsariya ^a   Jayaprakash, Venkatesan ^a   Mishra, Nibha ^a   Ojha, P ^a   Bhattacharya, S ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Amino imidazoles; Anti HIV; CoMFA and CoMSIA models; Cytotoxicity data

Indexed keywords

1 PHENYLAMINO 1H IMIDAZOLE DERIVATIVE; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE MOLECULAR FIELD ANALYSIS; COMPARATIVE MOLECULAR SIMILARITY INDICES ANALYSIS; CYTOTOXICITY; DRUG STRUCTURE; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ALGORITHMS; ANILINE COMPOUNDS; ANTI-HIV AGENTS; COMPUTER SIMULATION; DATABASES, FACTUAL; IMIDAZOLES; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STEREOISOMERISM;

EID: 64249142581     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.09.043     Document Type: Article

References (15)

1. Simon V., Ho D.D., and Karim Q.A. Lancet 368 (2006) 489-504
2. http://www.unaids.org/Unaids/EN/Resources/Publications.
3. De Clercq E. J. Med. Chem. 38 (1995) 2491-2517
4. Artico M. Farmaco 51 (1996) 305-331
5. De Clercq E. Mini-Rev. Med. Chem. 2 (2002) 163-175
6. http://www.merck.com/newsroom/press_releases/product/2007_1012.html.
7. Dubey S., Satyanarayana Y.D., and Lavania H. Eur. J. Med. Chem. 42 (2007) 1159-1168
8. Briz V., Poveda E., and Soriano V. J. Antimicrob. Chemother. 57 (2006) 619-627
9. Lagoja I.M., Pannecouque C., Aerschot A.V., Witvrouw M., Debyser Z., Balzarini J., Hardewijn P., and De Clercq E. J. Med. Chem. 46 (2003) 1546
10. Roy K., and Leonard J.T. Bioorg. Med. Chem. 14 (2006) 1039-1046
11. Arab Chamjangali M., Beglari M., and Bagherian G. J. Mol. Graphics Modell. 26 (2007) 360-367
12. Cramer R.D., Patterson D.E., and Bunce J.D. J. Am. Chem. Soc. 110 (1988) 5959-5967
13. Klebe G., Abraham U., and Mietzner T. J. Med. Chem. 37 (1994) 4130-4146
14. Roy P.P., and Roy K. QSAR Comb. Sci. 27 (2008) 302-313
15. Cao H., Zhang H., Zheng X., and Gao D. J. Mol. Graphics Modell. 26 (2007) 236-245