Passive absorption of fentanyl from the fentanyl HCl iontophoretic transdermal system

Current Medical Research and Opinion

Volumn 25, Issue 2, 2009, Pages 363-366

  Sathyan, Gayatri ^a   Phipps, Brad ^a,b   Gupta, Suneel K ^a  

^a ALZA CORPORATION   (United States)

^b NONE   (United States)

Author keywords

Fentanyl ITS; Passive absorption; Transdermal

Indexed keywords

FENTANYL; NARCOTIC ANALGESIC AGENT;

ADULT; ANALGESIA; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; CLINICAL TRIAL; DIZZINESS; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DYSPEPSIA; FEMALE; HEADACHE; HUMAN; INJECTION SITE ERYTHEMA; IONTOPHORESIS; LIMB PAIN; MALE; RESPIRATION DEPRESSION; SOMNOLENCE; AREA UNDER THE CURVE; BLOOD; INTRADERMAL DRUG ADMINISTRATION; LIQUID CHROMATOGRAPHY; MIDDLE AGED; TANDEM MASS SPECTROMETRY;

ADMINISTRATION, CUTANEOUS; ADULT; ANALGESICS, OPIOID; AREA UNDER CURVE; CHROMATOGRAPHY, LIQUID; FENTANYL; HUMANS; IONTOPHORESIS; MIDDLE AGED; TANDEM MASS SPECTROMETRY;

EID: 64249125571     PISSN: 03007995     EISSN: 14734877     Source Type: Journal    
DOI: 10.1185/03007990802594941     Document Type: Article

References (16)

1. Grond S, Hall J, Spacek A, et al. Iontophoretic transdermal system using fentanyl compared with patient-controlled intravenous analgesia using morphine for postoperative pain management. Br J Anaesth 2007;98:806-815 (Pubitemid 47072593)
2. Hartrick CT, Bourne MH, Gargiulo K, et al. Fentanyl iontophoretic transdermal system for acute-pain management after orthopedic surgery: a comparative study with morphine intravenous patient-controlled analgesia. Reg Anesth Pain Med 2006;31:546-554 (Pubitemid 44810090)
3. Minkowitz HS, Rathmell JP, Vallow S, et al. Efficacy and safety of the fentanyl iontophoretic transdermal system (ITS) and intravenous patient-controlled analgesia (IV PCA) with morphine for pain management following abdominal or pelvic surgery. Pain Med 2007;8:657-668 (Pubitemid 350142913)
4. Viscusi ER, Reynolds L, Chung F, et al. Patient-controlled transdermal fentanyl hydrochloride vs intravenous morphine pump for postoperative pain: a randomized controlled trial. JAMA 2004;291:1333-1341 (Pubitemid 38541648)
5. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th edn, Text Revision. Washington, DC: American Psychiatric Association, 2000
6. Anderson LS, Grafelman DD, Carnes EJ, et al. Development and validation of an exceptionally sensitive LC-MS/MS method to analyze fentanyl and naltrexone in human serum. AAPS PharmSci 2002;4(4):[abstract W5207]
7. Cutler DJ. Linear systems analysis in pharmacokinetics. J Pharmacokinet Biopharm 1978;6:265-282 (Pubitemid 8379264)
8. Veng-Pedersen P. Linear and nonlinear system approaches in pharmacokinetics: how much do they have to offer? I. General considerations. J Pharmacokinet Biopharm 1988;16:413-472 (Pubitemid 18228871)
9. Gillespie WR. PCDCON: Manual of Deconvolution for Pharmacokinetic Analysis. Austin, TX: University of Texas, 1991
10. Gupta SK, Southam M, Sathyan G, et al. Effect of current density on pharmacokinetics following continuous or intermittent input from a fentanyl electrotransport system. J Pharm Sci 1998;87:976-981 (Pubitemid 28381255)
11. DURAGESIC® (fentanyl transdermal system) [package insert]. Titusville, NJ: Ortho-McNeil-Janssen Pharmaceuticals, Inc., 2008
12. Sathyan G, Jaskowiak J, Evashenk M, et al. Characterisation of the pharmacokinetics of fentanyl HCl patient-controlled transdermal system (PCTS): effect of current magnitude and multiple-day dosing, and comparison with IV fentanyl administration. Clin Pharmacokinet 2005;44(Suppl 1):7-15 (Pubitemid 41626712)
13. Gourlay GK, Kowalski SR, Plummer JL, et al. Fentanyl blood concentration-analgesic response relationship in the treatment of postoperative pain. Anesth Analg 1988;67:329-337 (Pubitemid 18098934)
14. Mildh LH, Scheinin H, Kirvelä OA. The concentration-effect relationship of the respiratory depressant effects of alfentanil and fentanyl. Anesth Analg 2001;93:939-946 (Pubitemid 32905983)
15. Varvel JR, Shafer SL, Hwang SS, et al. Absorption characteristics of transdermally administered fentanyl. Anesthesiology 1989;70:928-934 (Pubitemid 19148495)
16. Sathyan G, Zomorodi K, Gidwani S, et al. The effect of dosing frequency on the pharmacokinetics of fentanyl HCl patient-controlled transdermal system (PCTS). Clin Pharmacokinet 2005;44(Suppl 1):17-24 (Pubitemid 41626713)