Hyperinfection strongyloidiasis in a liver transplant recipient treated with parenteral ivermectin: Case report

Transplant Infectious Disease

Volumn 11, Issue 2, 2009, Pages 137-142

  Lichtenberger, P ^a   Rosa Cunha, I ^a   Morris, M ^a   Nishida, S ^b   Akpinar, E ^b   Gaitan, J ^c   Tzakis, A ^b   Doblecki Lewis, Susanne ^a,d  

^a Division of Infectious Diseases ^*  (United States)

^b Division of Liver and Gastrointestinal Transplantation   (United States)

^c JACKSON MEMORIAL HOSPITAL   (United States)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Liver transplantation; Parenteral ivermectin; Severe strongyloidiasis; Strongyloides stercoralis

Indexed keywords

ALBENDAZOLE; ALEMTUZUMAB; COTRIMOXAZOLE; DAPTOMYCIN; IVERMECTIN; LINEZOLID; METHYLPREDNISOLONE; METRONIDAZOLE; MICAFUNGIN; PHENYTOIN; PREDNISONE; TACROLIMUS; VALGANCICLOVIR;

ACUTE GRAFT REJECTION; ADULT; ANTIBIOTIC THERAPY; ARTICLE; BACTEREMIA; CANDIDA GLABRATA; CASE REPORT; CLOSTRIDIUM DIFFICILE INFECTION; DISEASE COURSE; ENZYME IMMUNOASSAY; FECES ANALYSIS; FEMALE; FUNGEMIA; GRAND MAL SEIZURE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LIVER TRANSPLANTATION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PRIORITY JOURNAL; STRONGYLOIDES STERCORALIS; STRONGYLOIDIASIS; VANCOMYCIN RESISTANT ENTEROCOCCUS; VENTILATOR ASSOCIATED PNEUMONIA;

ADMINISTRATION, ORAL; ALBENDAZOLE; ANIMALS; ANTHELMINTICS; FEMALE; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, SUBCUTANEOUS; IVERMECTIN; LIVER TRANSPLANTATION; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; STRONGYLOIDES STERCORALIS; STRONGYLOIDIASIS; SUPERINFECTION;

EID: 64249119849     PISSN: 13982273     EISSN: 13993062     Source Type: Journal    
DOI: 10.1111/j.1399-3062.2008.00358.x     Document Type: Article

References (26)

1. Barsoum RS. Parasitic infections in organ transplantation. Exp Clin Transplant 2004 2 (2) : 258 267.
2. Barsoum RS. Parasitic infections in transplant recipients. Nat Clin Pract Nephrol 2006 2 (9) : 490 503.
3. Keiser PB, Nutman TB. Strongyloides stercoralis in the immunocompromised population. Clin Microbiol Rev 2004 17 (1) : 208 217.
4. Morgan JS, Schaffner W, Stone WJ. Opportunistic strongyloidiasis in renal transplant recipients. Transplantation 1986 42 (5) : 518 524.
5. Said T, Nampoory MP, Nair MP, et al. Hyperinfection strongyloidiasis: an anticipated outbreak in kidney transplant recipients in Kuwait. Transplant Proc 2007 39 (4) : 1014 1015.
6. Orlent H, Crawley C, Cwynarski K, Dina R, Apperley J. Strongyloidiasis pre and post autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 2003 32 (1) : 115 117.
7. Schaeffer MW, Buell JF, Gupta M, Conway GD, Akhter SA, Wagoner LE. Strongyloides hyperinfection syndrome after heart transplantation: case report and review of the literature. J Heart Lung Transplant 2004 23 (7) : 905 911.
8. Patel G, Arvelakis A, Sauter BV, Gondolesi GE, Caplivski D, Huprikar S. Strongyloides hyperinfection syndrome after intestinal transplantation. Transpl Infect Dis 2008 10 (2) : 137 141. Epub July 1, 2007, doi :.
9. El Masry HZ, O'Donnell J. Fatal strongyloides hyperinfection in heart transplantation. J Heart Lung Transplant 2005 24 (11) : 1980 1983.
10. Ben-Youssef R, Baron P, Edson F, Raghavan R, Okechukwu O. Strongyloides stercoralis infection from pancreas allograft: case report. Transplantation 2005 80 (7) : 997 998.
11. Gupta S, Jain A, Fanning TV, Couriel DR, Jimenez CA, Eapen GA. An unusual cause of alveolar hemorrhage post hematopoietic stem cell transplantation: a case report. BMC Cancer 2006 6 : 87 92.
12. Gann PH, Neva FA, Gam AA. A randomized trial of single- and two-dose ivermectin versus thiabendazole for treatment of strongyloidiasis. J Infect Dis 1994 169 (5) : 1076 1079.
13. Marti H, Haji HJ, Savioli L, et al. A comparative trial of a single-dose ivermectin versus three days of albendazole for treatment of Strongyloides stercoralis and other soil-transmitted helminthic infections in children. Am J Trop Med Hyg 1996 55 (5) : 477 481.
14. Guzzo CA, Furktek CI, Porras AG, et al. Safety, tolerability and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects. J Clin Pharmacol 2002 42 : 1122 1133.
15. Fox LM. Ivermectin uses and impact 20 years on. Curr Opin Infect Dis 2006 19 (6) : 588 593.
16. Turner SA, Maclean JD, Fleckenstein L, Greenaway C. Parenteral administration of ivermectin in a patient with disseminated strongyloidiasis. Am J Trop Med Hyg 2005 73 (5) : 911 914.
17. Marriner S, Mc Kinnon I, Bogan JA. The pharmacokinetics of ivermectin at oral and subcutaneous administration to sheep and horses. J Vet Pharmacol Ther 1987 10 (2) : 175 179.
18. Chiodini PL, Reid AJ, Wiselka MJ, Firmin R, Foweraker J. Parenteral ivermectin in strongyloides hyperinfection. Lancet 2000 355 (9197) : 43 44.
19. Hauber HP, Galle J, Chiodini PL, et al. Fatal outcome of a hyperinfection syndrome despite successful eradication of strongyloides with subcutaneous ivermectin. Infection 2005 33 (5-6) : 383 386.
20. Marty FM, Lowry CM, Rodriguez M, et al. Treatment of human disseminated strongyloidiasis with a parenteral veterinary formulation of ivermectin. Clin Infect Dis 2005 41 (1) : e5 e8.
21. Salluh JI, Feres GA, Velasco E, Holanda G, Toscano L, Soares M. Successful use of parenteral ivermectin in an immunosuppressed patient with disseminated strongyloidiasis and septic shock. Intensive Care Med 2005 31 (9) : 1292.
22. Zaha O, Hirata T, Kinjo F, Saito A, Fukuhara H. Efficacy of ivermectin for chronic strongyloidiasis: two single doses given 2 weeks apart. J Infect Chemother 2002 8 (1) : 94 98.
23. Paul AJ, Tranquilli WJ, Seward RL, Todd KS Jr., DiPietro JA. Clinical observations in collies given ivermectin orally. Am J Vet Res 1987 48 (4) : 684 685.
24. Edwards G. Ivermectin: does P-glycoprotein play a role in neurotoxicity? Filaria J 2003 2 (S1) : S8.
25. Marques-Santos LF, Bernardo RR, de Paula EF, Rumajanek VM. Cyclosporine A and trifluperazin, two resistance modulating agents increase ivermectin neurotoxicity in mice. Pharmacol Toxicol 1999 84 (3) : 125 129.
26. Martin-Davila P, Fortun J, Lopez-Velez R, et al. Transmission of tropical and geographically restricted infections during solid organ transplantation. Clin Microb Rev 2008 21 (1) : 60 96.