메뉴 건너뛰기




Volumn 10, Issue SUPPL. 1, 2009, Pages

Clinical pharmacology of oxymorphone

Author keywords

Absorption; Metabolism pharmacokinetic; Opioids; Oxymorphone; Pharmacodynamic excretion

Indexed keywords

CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; MORPHINE; NALTREXONE; OPIATE; OXYMORPHONE; RIFAMPICIN;

EID: 64249084148     PISSN: 15262375     EISSN: 15264637     Source Type: Journal    
DOI: 10.1111/j.1526-4637.2009.00594.x     Document Type: Review
Times cited : (20)

References (48)
  • 4
    • 0010269640 scopus 로고
    • The analgesic equivalence to morphine and relative side action liability of oxymorphone (4-hydroxy-dihydromorphinon)
    • Eddy NB, Lee LEJ. The analgesic equivalence to morphine and relative side action liability of oxymorphone (4-hydroxy-dihydromorphinon). J Pharmacol Exp Ther 1959; 125: 116-21.
    • (1959) J Pharmacol Exp Ther , vol.125 , pp. 116-121
    • Eddy, N.B.1    Lee, L.E.J.2
  • 5
    • 0003979206 scopus 로고    scopus 로고
    • Endo Pharmaceuticals. Chadds Ford, PA: Author
    • Endo Pharmaceuticals. Data on File. Chadds Ford, PA: Author; 2003.
    • (2003) Data on File
  • 6
    • 0017580705 scopus 로고    scopus 로고
    • Comparisons of the analgesic effects of oral and intramuscular oxymorphone and morphine in patients with cancer
    • Beaver WT, Wallenstein SL, Houde RW, Rogers A. Comparisons of the analgesic effects of oral and intramuscular oxymorphone and morphine in patients with cancer. J Clin Pharmacol 1997; 17: 186-98.
    • (1997) J Clin Pharmacol , vol.17 , pp. 186-198
    • Beaver, W.T.1    Wallenstein, S.L.2    Houde, R.W.3    Rogers, A.4
  • 7
    • 3042595723 scopus 로고    scopus 로고
    • Establishing the dosage equivalency of oxymorphone extended release and oxycodone controlled release in patients with cancer pain: A randomized controlled study
    • Gabrail NY, Dvergsten C, Ahdieh H. Establishing the dosage equivalency of oxymorphone extended release and oxycodone controlled release in patients with cancer pain: A randomized controlled study. Curr Med Res Opin 2004; 20: 911-8.
    • (2004) Curr Med Res Opin , vol.20 , pp. 911-918
    • Gabrail, N.Y.1    Dvergsten, C.2    Ahdieh, H.3
  • 8
    • 13244272132 scopus 로고    scopus 로고
    • Effectiveness and safety of oral extended-release oxymorphone for the treatment of cancer pain: A pilot study
    • Epub Nov 9, 2004
    • Sloan P, Slatkin N, Ahdieh H. Effectiveness and safety of oral extended-release oxymorphone for the treatment of cancer pain: A pilot study. Support Care Cancer 2005; 13: 57-65. Epub Nov 9, 2004.
    • (2005) Support Care Cancer , vol.13 , pp. 57-65
    • Sloan, P.1    Slatkin, N.2    Ahdieh, H.3
  • 9
    • 33846339442 scopus 로고    scopus 로고
    • Assessment of dosing frequency of sustained-release opioid preparations in patients with chronic nonmalignant pain
    • Gallagher RM, Weiz-Bosna M, Gammaitoni A. Assessment of dosing frequency of sustained-release opioid preparations in patients with chronic nonmalignant pain. Pain Med 2007; 8: 71-4.
    • (2007) Pain Med , vol.8 , pp. 71-74
    • Gallagher, R.M.1    Weiz-Bosna, M.2    Gammaitoni, A.3
  • 10
    • 11144235004 scopus 로고    scopus 로고
    • Efficacy and safety of oxymorphone extended-release in chronic low back pain: Results of a randomized, double-blind, pkacebo- and active-controlled study
    • Hale ME, Dvergsten C, Gimbel J. Efficacy and safety of oxymorphone extended-release in chronic low back pain: Results of a randomized, double-blind, pkacebo- and active-controlled study. J Pain 2005; 6: 21-8.
    • (2005) J Pain , vol.6 , pp. 21-28
    • Hale, M.E.1    Dvergsten, C.2    Gimbel, J.3
  • 11
    • 33846635073 scopus 로고    scopus 로고
    • Efficacy and safety of OPANA ® ER (oxymorphone extended release) for relief of moderate to severe chronic low back pain in opioid-experienced patients: A 12-week, randomized, placebo-controlled study
    • Hale ME, Ahdieh H, Ma T, Rauck R. Efficacy and safety of OPANA ® ER (oxymorphone extended release) for relief of moderate to severe chronic low back pain in opioid-experienced patients: A 12-week, randomized, placebo-controlled study. J Pain 2007; 8: 175-84.
    • (2007) J Pain , vol.8 , pp. 175-184
    • Hale, M.E.1    Ahdieh, H.2    Ma, T.3    Rauck, R.4
  • 12
    • 33846671273 scopus 로고    scopus 로고
    • A 12-week, randomized, placebo-controlled trial assessing the safety and efficacy of oxymorphone extended release for opioid-naïve patients with chronic low back pain
    • Katz N, Rauck R, Ahdieh H, Ma T. Gerritsen van der Hoop R, Kerwin R, Podolsky G. A 12-week, randomized, placebo-controlled trial assessing the safety and efficacy of oxymorphone extended release for opioid-naïve patients with chronic low back pain. Curr Med Res Opin 2007; 23: 117-28.
    • (2007) Curr Med Res Opin , vol.23 , pp. 117-128
    • Katz, N.1    Rauck, R.2    Ahdieh, H.3    Ma, T.4    Gerritsen van der Hoop, R.5    Kerwin, R.6    Podolsky, G.7
  • 13
    • 33646872448 scopus 로고    scopus 로고
    • A 2-week, multicenter, randomized, double-blind, placebo-controlled dose-ranging, phase III trial comparing the efficacy of oxymoprohone extended release and placebo in adults with pain associated with osteoarthritis of the hip or knee
    • Kivitz A, Ma C, Ahdieh H, Galer B. A 2-week, multicenter, randomized, double-blind, placebo-controlled dose-ranging, phase III trial comparing the efficacy of oxymoprohone extended release and placebo in adults with pain associated with osteoarthritis of the hip or knee. Clin Ther 2006; 3: 352-64.
    • (2006) Clin Ther , vol.3 , pp. 352-364
    • Kivitz, A.1    Ma, C.2    Ahdieh, H.3    Galer, B.4
  • 14
    • 28444472350 scopus 로고    scopus 로고
    • Oxymorphone extended-release tablets relieve moderate to severe pain and improve physical function in osteoarthritis: Results of a randomized, double-blind, placebo- and active-controlled phase III trial
    • Matsumoto AK, Babul N, Ahdieh H. Oxymorphone extended-release tablets relieve moderate to severe pain and improve physical function in osteoarthritis: Results of a randomized, double-blind, placebo- and active-controlled phase III trial. Pain Med 2005; 6: 357-66.
    • (2005) Pain Med , vol.6 , pp. 357-366
    • Matsumoto, A.K.1    Babul, N.2    Ahdieh, H.3
  • 15
    • 17144390270 scopus 로고    scopus 로고
    • Safety, tolerability, and effective ness of oxymorphone extended release for moderate to severe osteoarthritis pain: A one-year study
    • McIlwain H, Ahdieh H. Safety, tolerability, and effective ness of oxymorphone extended release for moderate to severe osteoarthritis pain: A one-year study. Am J Ther 2005; 12: 106-12.
    • (2005) Am J Ther , vol.12 , pp. 106-112
    • McIlwain, H.1    Ahdieh, H.2
  • 16
    • 12144289451 scopus 로고    scopus 로고
    • Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, and hydromorphone
    • Ananthan S, Khare NK, Saini SK, et al. Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, and hydromorphone. J Med Chem 2004; 47: 1400-12.
    • (2004) J Med Chem , vol.47 , pp. 1400-1412
    • Ananthan, S.1    Khare, N.K.2    Saini, S.K.3
  • 17
    • 34748831695 scopus 로고    scopus 로고
    • Use of oxymorphone in the elderly
    • Guay DR. Use of oxymorphone in the elderly. Consult Pharm 2007; 22: 417-30.
    • (2007) Consult Pharm , vol.22 , pp. 417-430
    • Guay, D.R.1
  • 18
    • 0038653828 scopus 로고    scopus 로고
    • 13th edition. Whitehouse Station, NJ: Merck & Co
    • O'Neil MJ. The Merck Index, 13th edition. Whitehouse Station, NJ: Merck & Co.; 2001.
    • (2001) The Merck Index
    • O'Neil, M.J.1
  • 19
    • 0028105675 scopus 로고
    • Liposolubility and protein binding of oxycodone in vitro
    • Poyhia R, Seppala T. Liposolubility and protein binding of oxycodone in vitro. Pharmacol Toxicol 1994; 74: 23-7.
    • (1994) Pharmacol Toxicol , vol.74 , pp. 23-27
    • Poyhia, R.1    Seppala, T.2
  • 20
    • 0017813305 scopus 로고
    • Whole body autoradiographic localization of C[14]labeled morphine and nalorphine
    • Fand I, Sinatra R, Clouet D. Whole body autoradiographic localization of C[14]labeled morphine and nalorphine. Anat Rec 1978; 190: 392.
    • (1978) Anat Rec , vol.190 , pp. 392
    • Fand, I.1    Sinatra, R.2    Clouet, D.3
  • 21
    • 64249149270 scopus 로고    scopus 로고
    • Drug facts and comparisons
    • Drug facts and comparisons. 2006.
    • (2006)
  • 25
    • 0021971485 scopus 로고
    • Comparison of histamine release in human skin mast cells induced by morphine, fentanyl, and oxymorphone
    • Hermens JM, Ebertz JM, Hanifin JM, Hirshman CA. Comparison of histamine release in human skin mast cells induced by morphine, fentanyl, and oxymorphone. Anesthesiology 1985; 62: 124-9.
    • (1985) Anesthesiology , vol.62 , pp. 124-129
    • Hermens, J.M.1    Ebertz, J.M.2    Hanifin, J.M.3    Hirshman, C.A.4
  • 27
    • 0029930195 scopus 로고    scopus 로고
    • N-cubylmethyl substituted morphinoids as novel narcotic antagonists
    • Cheng CY, Hsin LW, Lin YP, et al. N-cubylmethyl substituted morphinoids as novel narcotic antagonists. Bioorg Med Chem 1996; 4: 73-80.
    • (1996) Bioorg Med Chem , vol.4 , pp. 73-80
    • Cheng, C.Y.1    Hsin, L.W.2    Lin, Y.P.3
  • 28
    • 0022645384 scopus 로고
    • Antinociceptive profiles of Mu and Kappa opioid agonists in a rat tooth pulp stimulation procedure
    • Steinfels GF, Cook L. Antinociceptive profiles of Mu and Kappa opioid agonists in a rat tooth pulp stimulation procedure. J Pharmacol Exp Ther 1986; 236: 111-7.
    • (1986) J Pharmacol Exp Ther , vol.236 , pp. 111-117
    • Steinfels, G.F.1    Cook, L.2
  • 29
    • 0003392747 scopus 로고    scopus 로고
    • Bethesda, MD: American Society of Health-System Pharmacists
    • American Hospital Formulary Service. Bethesda, MD: American Society of Health-System Pharmacists; 2006.
    • (2006) American Hospital Formulary Service
  • 30
    • 0037369176 scopus 로고    scopus 로고
    • Pharmacokinetic drug interactions of morphine, codeine, and their derivatives: Theory and clinical reality, part I
    • Armstrong SC, Cozza KL. Pharmacokinetic drug interactions of morphine, codeine, and their derivatives: Theory and clinical reality, part I. Psychosomatics 2003; 44: 167-71.
    • (2003) Psychosomatics , vol.44 , pp. 167-171
    • Armstrong, S.C.1    Cozza, K.L.2
  • 31
    • 16844377997 scopus 로고    scopus 로고
    • Oxymorphone extended release does not affect CYP2C9 or CYP3A4 metabolic pathways
    • Adams M, Pieniaszek HJ Jr, Gammanoni AR, et al. Oxymorphone extended release does not affect CYP2C9 or CYP3A4 metabolic pathways. J Clin Pharmacol 2005; 45: 337-45.
    • (2005) J Clin Pharmacol , vol.45 , pp. 337-345
    • Adams, M.1    Pieniaszek Jr., H.J.2    Gammanoni, A.R.3
  • 32
    • 0020601851 scopus 로고
    • Oxymorphone metabolism and urinary excretion in human, rat, guinea pig, rabbit, and dogs
    • Cone EJ, Darwin WD, Buchwald WF, Gorodetzky CW. Oxymorphone metabolism and urinary excretion in human, rat, guinea pig, rabbit, and dogs. Drug Metab Dispos 1983; 11: 446-50.
    • (1983) Drug Metab Dispos , vol.11 , pp. 446-450
    • Cone, E.J.1    Darwin, W.D.2    Buchwald, W.F.3    Gorodetzky, C.W.4
  • 33
    • 0029118722 scopus 로고
    • Morphine-3-glucuronide: Hyperglycemic and neuroendocrine potentiating effects
    • Hashiguchi Y, Molina PE, Abumrad NN. Morphine-3-glucuronide: Hyperglycemic and neuroendocrine potentiating effects. Brain Res 1995; 694: 13-20.
    • (1995) Brain Res , vol.694 , pp. 13-20
    • Hashiguchi, Y.1    Molina, P.E.2    Abumrad, N.N.3
  • 34
    • 0035497973 scopus 로고    scopus 로고
    • Morphine-6beta-glucuronide and morphine-3-glucuronide, opioid receptor agonists with different potencies
    • Ulens C, Baker L, Ratka A, Waumans D, Tytgat J. Morphine-6beta-glucuronide and morphine-3-glucuronide, opioid receptor agonists with different potencies. Biochem Pharmacol 2001; 62: 1273-82.
    • (2001) Biochem Pharmacol , vol.62 , pp. 1273-1282
    • Ulens, C.1    Baker, L.2    Ratka, A.3    Waumans, D.4    Tytgat, J.5
  • 36
    • 48449091303 scopus 로고    scopus 로고
    • Oxymorphone and oxymorphone extended release: A pharmacotherapeutic review
    • Sloan PA, Barkin RL. Oxymorphone and oxymorphone extended release: A pharmacotherapeutic review. J Opioid Manag 2008; 4: 131-44.
    • (2008) J Opioid Manag , vol.4 , pp. 131-144
    • Sloan, P.A.1    Barkin, R.L.2
  • 37
    • 16844373756 scopus 로고    scopus 로고
    • Single- and multiple-dose pharmacokinetic and dose-proportionality study of oxymorphone immediate-release tablets
    • Adams MP, Ahdieh H. Single- and multiple-dose pharmacokinetic and dose-proportionality study of oxymorphone immediate-release tablets. Drugs RD 2005; 6: 91-9.
    • (2005) Drugs RD , vol.6 , pp. 91-99
    • Adams, M.P.1    Ahdieh, H.2
  • 38
    • 34547575671 scopus 로고    scopus 로고
    • Efficacy and tolerability of oxymorphone immediate release for acute postoperative pain after abnormal surgery: A randomized, double-blind, active and placebo-controlled, parallel-group trial
    • Aqua K, Gimbel J, Singla N, etal. Efficacy and tolerability of oxymorphone immediate release for acute postoperative pain after abnormal surgery: A randomized, double-blind, active and placebo-controlled, parallel-group trial. Clin Ther 2007; 25: 1008-12.
    • (2007) Clin Ther , vol.25 , pp. 1008-1012
    • Aqua, K.1    Gimbel, J.2    Singla, N.3
  • 39
    • 6444221477 scopus 로고    scopus 로고
    • The efficacy and safety of oral immediate-release oxymorphone for postsurgical pain
    • Gimbel J, Ahdieh H. The efficacy and safety of oral immediate-release oxymorphone for postsurgical pain. Anesth Analg 2004; 99: 1472-7.
    • (2004) Anesth Analg , vol.99 , pp. 1472-1477
    • Gimbel, J.1    Ahdieh, H.2
  • 40
    • 0024406693 scopus 로고
    • Pharmacokinetics and clinical efficacy of oral morphine solution and controlled-release morphine tablets in cancer patients
    • Thirlwell MP, Sloan PA, Maroun JA, et al. Pharmacokinetics and clinical efficacy of oral morphine solution and controlled-release morphine tablets in cancer patients. Cancer 1989; 63: 2275-83.
    • (1989) Cancer , vol.63 , pp. 2275-2283
    • Thirlwell, M.P.1    Sloan, P.A.2    Maroun, J.A.3
  • 41
    • 0026451237 scopus 로고
    • Comparative oxycodone pharmacokinetics in humans after intravenous, oral, and rectal administration
    • Leow KP, Smith MT, Watt JA, Williams BE, Cramond T. Comparative oxycodone pharmacokinetics in humans after intravenous, oral, and rectal administration. Ther Drug Monit 1992; 14: 479-84.
    • (1992) Ther Drug Monit , vol.14 , pp. 479-484
    • Leow, K.P.1    Smith, M.T.2    Watt, J.A.3    Williams, B.E.4    Cramond, T.5
  • 42
    • 0026492647 scopus 로고
    • Single-dose and steady-state pharmacokinetics and pharmacodynamics of oxycodone in patients with caner
    • Leow KP, Smith MT, Williams B, Cramond T. Single-dose and steady-state pharmacokinetics and pharmacodynamics of oxycodone in patients with caner. Clin Pharmacol Ther 1992; 52: 487-95.
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 487-495
    • Leow, K.P.1    Smith, M.T.2    Williams, B.3    Cramond, T.4
  • 43
    • 1842480273 scopus 로고    scopus 로고
    • Pharmacokinetics and dose-proportionality of oxymorphone extended release and its metabolites: Results of a randomized crossover study
    • Adams MP, Ahdieh H. Pharmacokinetics and dose-proportionality of oxymorphone extended release and its metabolites: Results of a randomized crossover study. Pharmacotherapy 2004; 24: 468-76.
    • (2004) Pharmacotherapy , vol.24 , pp. 468-476
    • Adams, M.P.1    Ahdieh, H.2
  • 44
    • 33748918495 scopus 로고    scopus 로고
    • Opioids used in primary care for the management of pain: A pharamocologic, pharmacotherapeutic, and pharmacodynamic overview
    • In: Boswell MV, Cole BE, eds. 7th edition. New York: Taylor & Francis
    • Barkin RI, Fusco AM, Barkin SJ. Opioids used in primary care for the management of pain: A pharamocologic, pharmacotherapeutic, and pharmacodynamic overview. In: Boswell MV, Cole BE, eds. Wieiner's Pain Management: A Practical Guide for Clinicians, 7th edition. New York: Taylor & Francis; 2006: 789-804.
    • (2006) Wieiner's Pain Management: A Practical Guide for Clinicians , pp. 789-804
    • Barkin, R.I.1    Fusco, A.M.2    Barkin, S.J.3
  • 45
    • 0003979209 scopus 로고    scopus 로고
    • Endo Pharmaceuticals Inc. Chadds Ford, PA: Author
    • Endo Pharmaceuticals Inc. Data on File. Chadds Ford, PA: Author; 2002.
    • (2002) Data on File
  • 46
    • 18744365791 scopus 로고    scopus 로고
    • Measurements of plasma oxycodone, noroxycodone, and oxymorphone levels in a patient with bilateral nephrectomy who is undergoing haemodialysis
    • Lee MA, Leng MEF, Cooper RM. Measurements of plasma oxycodone, noroxycodone, and oxymorphone levels in a patient with bilateral nephrectomy who is undergoing haemodialysis. Pall Med 2005; 19: 259-60.
    • (2005) Pall Med , vol.19 , pp. 259-260
    • Lee, M.A.1    Leng, M.E.F.2    Cooper, R.M.3
  • 47
    • 43549121967 scopus 로고    scopus 로고
    • Evidence that morphine is metabolized to hydromorphone but not to oxymorphone
    • Cone EJ, Caplan YH, Moser F, Robert T, Black D. Evidence that morphine is metabolized to hydromorphone but not to oxymorphone. J Anal Toxicol 2008; 32: 319-23.
    • (2008) J Anal Toxicol , vol.32 , pp. 319-323
    • Cone, E.J.1    Caplan, Y.H.2    Moser, F.3    Robert, T.4    Black, D.5
  • 48
    • 43749100932 scopus 로고    scopus 로고
    • The detection of hydromorphone in urine specimens with high morphine concentrations
    • McDonough PC, Levine B, Vorce S, Jufer RA, Fowler D. The detection of hydromorphone in urine specimens with high morphine concentrations. J Forensic Sci 2008; 53: 752-4.
    • (2008) J Forensic Sci , vol.53 , pp. 752-754
    • McDonough, P.C.1    Levine, B.2    Vorce, S.3    Jufer, R.A.4    Fowler, D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.