Heritable pathologic cardiac hypertrophy in adulthood is preceded by neonatal cardiac growth restriction

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 296, Issue 3, 2009, Pages

  Porrello, Enzo R ^a,b   Bell, James R ^a   Schertzer, Jonathan D ^a,d   Curl, Claire L ^a   McMullen, Julie R ^b   Mellor, Kimberley M ^a   Ritchie, Rebecca H ^b   Lynch, Gordon S ^a   Harrap, Stephen B ^a   Thomas, Walter G ^b,c   Delbridge, Lea M D ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Apoptosis; Cardiac development; Developmental origins of adult disease; Genetics; Physiological and pathological cardiac hypertrophy; Proliferation

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL GROWTH; CELL SIZE; CELL VIABILITY; CONTROL GROUP; CONTROLLED STUDY; DEVELOPMENTAL STAGE; ENZYME ACTIVATION; EXPERIMENTAL RAT; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERINATAL DEVELOPMENT; PRIORITY JOURNAL; RAT; ANIMAL; APOPTOSIS; CARDIOMEGALY; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; DISEASE COURSE; DRUG EFFECT; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEART; HEART MUSCLE; IN VITRO STUDY; LONGEVITY; NEWBORN; NICK END LABELING; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPONTANEOUSLY HYPERTENSIVE RAT; ULTRASTRUCTURE; WESTERN BLOTTING;

CALCINEURIN; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BLOTTING, WESTERN; CALCINEURIN; CARDIOMEGALY; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; DISEASE PROGRESSION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEART; IN SITU NICK-END LABELING; LONGEVITY; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIUM; MYOCYTES, CARDIAC; RATS; RATS, INBRED SHR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 64149115861     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.90919.2008     Document Type: Article

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