Pancreatic differentiation from pluripotent stem cells: Tweaking the system

Cell Research

Volumn 19, Issue 4, 2009, Pages 395-396

  Holland, Andrew M ^a   Elefanty, Andrew G ^a   Stanley, Edouard G ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; ACTIVIN A; ANDROSTANE DERIVATIVE; EPIDERMAL GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; TRANSFORMING GROWTH FACTOR BETA; WORTMANNIN;

ARTICLE; CELL DIFFERENTIATION; CYTOLOGY; DRUG ANTAGONISM; EMBRYONIC STEM CELL; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; PANCREAS ISLET BETA CELL; PLURIPOTENT STEM CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTIVINS; ANDROSTADIENES; CELL DIFFERENTIATION; DIABETES MELLITUS, TYPE 1; EMBRYONIC STEM CELLS; EPIDERMAL GROWTH FACTOR; HUMANS; INSULIN-SECRETING CELLS; PLURIPOTENT STEM CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 64149115299     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2009.37     Document Type: Article

References (11)

1. Korsgren O, Nilsson B, Berne C, et al. Current status of clinical islet transplantation. Transplantation 2005; 79:1289-1293.
2. Kroon E, Martinson LA, Kadoya K, et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol 2008; 26:443-452.
3. Jiang W, Shi Y, Zhao D, et al. In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Res 2007; 17:333-344.
4. Zhang D, Jiang W, Liu M, et al. Highly efficient differentiation of human ES cells and iPS cells into mature pancreaticinsulin-producing cells. Cell Res 2009; 19:429-438.
5. McLean AB, D'Amour KA, Jones KL, et al. Activin a efficiently specifies definitive endoderm from human embryonicstem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells 2007; 25:29-38.
6. Stafford D, Prince VE. Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development. Curr Biol 2002; 12:1215-1220.
7. Huotari MA, Palgi J, Otonkoski T. Growth factor-mediated proliferation and differentiation of insulin-producing INS-1 and RINm5F cells: identification of betacellulin as a novel beta-cell mitogen. Endocrinology 1998; 139:1494-1499.
8. Yamamoto K, Miyagawa J, Waguri M, et al. Recombinant human betacellulin promotes the neogenesis of beta-cells and ameliorates glucose intolerance in mice with diabetes induced by selective alloxan perfusion. Diabetes 2000; 49:2021-2027.
9. Sandler S, Andersson A, Korsgren O, et al. Tissue culture of human fetal pancreas. Effects of nicotinamide on insulin production and formation of isletlike cell clusters. Diabetes 1989; 38 Suppl 1:168-171.
10. Xu G, Stoffers DA, Habener JF, Bonner- Weir S. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 1999; 48:2270-2276.
11. Lehmann R, Zuellig RA, Kugelmeier P, et al. Superiority of small islets in human islet transplantation. Diabetes 2007; 56:594-603.