The synthesis of novel pH-sensitive poly(vinyl alcohol) composite hydrogels using a freeze/thaw process for biomedical applications

International Journal of Pharmaceutics

Volumn 372, Issue 1-2, 2009, Pages 154-161

  Mc Gann, Michael J ^a   Higginbotham, Clement L ^a   Geever, Luke M ^a   Nugent, Michael J D ^a  

^a Athletic Rehabilitation Therapy Ireland   (Ireland)

Author keywords

Aspirin; Drug delivery; Hydrogel composite; Poly(vinyl alcohol)

Indexed keywords

ACETYLSALICYLIC ACID; POLYACRYLIC ACID; POLYVINYL ALCOHOL;

ARTICLE; BIOMEDICAL ENGINEERING; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; FLOW KINETICS; FREEZE THAWING; GLASS TRANSITION TEMPERATURE; HYDROGEL; HYDROGEN BOND; PH; PRIORITY JOURNAL; WOUND;

BIOMEDICAL TECHNOLOGY; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; FREEZING; HYDROGELS; HYDROGEN-ION CONCENTRATION; POLYVINYL ALCOHOL;

EID: 64149100439     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.01.008     Document Type: Article

References (39)

1. Brahim S., Narinesingh D., and Guiseppi-Elie A. Polypyrrole-hydrogel composites for the construction of clinically important biosensors. Biosens. Bioelectron. 17 (2002) 53-59
2. ®) in limiting scar formation. J. Burns Wounds 4 (2005) 119-127
3. Devine D.M., Devery S.M., Lyons J.G., Geever L.M., Kennedy J.E., and Higginbotham C.L. Multifunctional polyvinylpyrrolidinone-polyacrylic acid copolymer hydrogels for biomedical applications. Int. J. Pharm. 326 (2006) 50-59
4. Gerlach G., Guenther M., Sorber J., Suchaneck G., Arndt K.F., and Richter A. Chemical and pH sensors based on the swelling behavior of Hydrogels. Sens. Actuators B 111-112 (2005) 555-561
5. Hassan C.M., and Peppas N.A. Structure and morphology of freeze/thaw hydrogels. Macromolecules 33 (2000) 2472-2479
6. Hassan C.M., and Peppas N.A. Structure and applications of poly(vinyl alcohol) hydrogels produced by conventional crosslinking or by freezing/thawing methods. J. Adv. Polym. Sci. (2000) 37-65
7. Hassan C.M., Ward J.H., and Peppas N.A. Modeling of crystal dissolution of poly(vinyl alcohol) gels produced by freezing/thawing processes. Polymer 41 (2000) 6729-6739
8. Hennink W.E., and Van Nostrum C.F. Novel crosslinking methods to design hydrogels. Adv. Drug Deliv. Rev. 54 (2002) 13-36
9. Hernández R., Sarafian A., López D., and Mijangos C. Viscoelastic properties of poly(vinyl alcohol) hydrogels and ferrogels obtained through freezing-thawing cycles. Polymer 46 (2004) 5543-5549
10. Hickey A.S., and Peppas N.A. Mesh size and diffusive characteristics of semicrystalline poly(vinyl alcohol) membranes prepared by freezing/thawing techniques. J. Membr. Sci. 107 (1995) 229-237
11. Hickey A.S., and Peppas N.A. Solute diffusion in poly(vinyl alcohol)/poly(acrylic acid) composite films using freezing/thawing techniques. Polymer 38 (1997) 5931-5936
12. Hirankumar G., Selvasekarapandian S., Kuwata N., Kawamura J., and Hattori T. Thermal, electrical and optical studies on the poly(vinyl alcohol) based polymer electrolytes. J. Power Sources 144 (2005) 262-267
13. Hoffman A.S. Hydrogels for biomedical applications. Adv. Drug Deliv. Rev. 43 (2002) 3-12
14. Huang H., Gu L., and Ozaki Y. Non-isothermal crystallization and thermal transitions of a biodegradable, partially hydrolyzed poly(vinyl alcohol). Polymer 47 (2006) 3935-3945
15. Huang Y.H., Lu J., and Xiao C.B. Thermal and mechanical properties of cationic guar gum/poly(acrylic acid) hydrogel films. Polym. Degrad. Stab. 92 (2007) 1072-1081
16. Jin X., and Hsieh Y.-L. pH-responsive swelling behavior of poly(vinyl alcohol)/poly(acrylic acid) bi-component fibrous hydrogel films. Polymer 46 (2005) 5149-5160
17. Kim B., and Peppas N.A. Analysis of molecular interactions in poly(methacrylic acid-g-ethylene glycol) hydrogels. Polymer 44 (2003) 3701-3707
18. Langer R. Drugs delivery and targeting. Nature 392 (1998) 5
19. Langer R. Drugs on target. Science 293 (2001) 58
20. Langer R., and Kost J. Responsive polymeric delivery systems. Adv. Drug Deliv. Rev. 46 (2001) 125-148
21. Lowman A.M., and Peppas N.A. Hydrogels. In: Mathiowitz E. (Ed). Encyclopedia of Controlled Drug Delivery (1999), Wiley, New York 397-418
22. Lozinsky V.I., Galaev I.Y., Plieva F.M., Savina I.N., Jungvid H., and Mattiasson B. Polymeric cryogels as promising materials of biotechnological interest. Trends Biotechnol. 21 (2003) 445-451
23. Mahaveer D.K., and Aminabhavi T.M. Poly(vinyl alcohol) and poly(acrylic acid) sequential interpenetrating network pH-sensitive microspheres for the delivery of diclofenac sodium to the intestine. J. Control. Release 96 (2004) 9-20
24. Maurer J.J., Eustace D.J., and Ratcliffet C.T. Thermal characterization of poly(acrylic acid). Macromolecules 20 (1987) 196-202
25. Moschou E.A., Madou M.J., Bachas L.G., and Daunert S. Voltage-switchable artificial muscles actuating at near neutral pH. Sens. Actuators B 115 (2006) 379-383
26. Nugent M.J.D., and Higginbotham C.L. Preparation of novel freeze thawed for poly(vinyl alcohol) composite hydrogel for drug delivery applications. Eur. J. Pharm. Biopharm. 67 (2007) 377-386
27. Pal K., and Banthia A.K. Polyvinyl alcohol-gelatin patches of salicylic acid: preparation, characterization and drug release studies. J. Biomater. Appl. (2006) 75-91
28. Park J.S., Park J.W., and Ruckenstein E. Thermal and dynamic mechanical analysis of PVA/MC blend hydrogels. Polymer 42 (2001) 4271-4280
29. Peppas N.A. Turbidimetric studies of aqueous poly(vinyl alcohol) solutions. Macromol. Chem. Phys. 176 (1975) 3433-3440
30. Peppas N.A. Hydrogels of poly(vinyl alcohol) and its copolymers. Hydrogels Med. Pharm. 2 (1987) 1-48
31. Peppas N.A., and Scott J.E. Controlled release from poly(vinyl alcohol) gels prepared by freezing-thawing processes. J. Control. Release 18 (1992) 95-100
32. Peppas N.A., Keys K.B., Torres-Lugo M., and Lowman A.M. Poly(ethylene glycol)-containing hydrogels in drug delivery. J. Control. Release 62 (1999) 81-87
33. Qiu Y., and Park K. Environment-sensitive hydrogels for drug delivery. Adv. Drug Deliv. Rev. 53 (2001) 321-339
34. Ritger P.L., and Peppas N.A. A simple equation for description of solute release. I. Fickian and non-Fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs. J. Control. Release 5 (1987) 23-26
35. Siegel R.A., and Kost J. pH-sensitive gels: swelling equilibria, kinetics and applications for drug delivery. Pulsed Self-regulated Drug Deliv. (1990) 129-157
36. Sinclair G.W., and Peppas N.A. Analysis of Fickian transport in polymers using simplified exponential expressions. J. Membr. Sci. 17 (1984) 329-331
37. Staudt-Bickel C., and Lichtenthaler R.N. Pervaporation thermodynamic properties and selection of film polymers. Polym. Sci. 36 (1994) 1628-1640
38. Stauffer S.R., and Peppas N.A. Poly(vinyl alcohol) hydrogels prepared by freezing thawing cyclic processing. Polymer 33 (1992) 3932-3936
39. Wu G., Su B., Zhang W., and Wang C. In vitro behaviors of hydroxyapatite reinforced polyvinyl alcohol hydrogel composite. Mater. Chem. Phys. 107 (2008) 364-369