Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations

Molecular Immunology

Volumn 46, Issue 8-9, 2009, Pages 1696-1701

  Swierzko, Anna St ^a   Cedzynski, Maciej ^a   Domzalska Popadiuk, Iwona ^b   MacDonald, Shirley L ^c   Borkowska Klos, Monika ^d   Atkinson, Anne P M ^c   Szala, Agnieszka ^a   Jopek, Aleksandra ^d   Jensenius, Jens C ^e   Kawakami, Masaya ^f   Szczapa, Jerzy ^d   Matsushita, Misao ^g   Szemraj, Janusz ^h   Turner, Marc L ^c   Kilpatrick, David C ^c  

^a INSTITUTE OF MEDICAL BIOLOGY   (Poland)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

^c SCOTTISH NATIONAL BLOOD TRANSFUSION SERVICE   (United Kingdom)

^d POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^e AARHUS UNIVERSITY   (Denmark)

^f KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^g TOKAI UNIVERSITY   (Japan)

^h MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Innate immunity; Lectin pathway of complement; MASP 2; Neonate

Indexed keywords

MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEINASE; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEINASE 2; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; BIRTH WEIGHT; COMPLEMENT LECTIN PATHWAY; CONTROLLED STUDY; ENZYME BLOOD LEVEL; FEMALE; GENE MUTATION; GENOTYPE; GESTATIONAL AGE; HETEROZYGOSITY; HOMOZYGOTE; HUMAN; INNATE IMMUNITY; LOW BIRTH WEIGHT; MALE; NEWBORN; PERINATAL INFECTION; PREMATURITY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; UMBILICAL CORD BLOOD;

BIRTH WEIGHT; COHORT STUDIES; FEMALE; FETAL BLOOD; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GESTATIONAL AGE; HUMANS; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; INFANT, NEWBORN, DISEASES; INFECTION; MALE; MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES; POLYMORPHISM, SINGLE NUCLEOTIDE; PREMATURE BIRTH;

EID: 64149087423     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.02.022     Document Type: Article

References (30)

1. Cedzynski M., Szemraj J., Swierzko A.S., Bak-Romaniszyn L., Banasik M., Zeman K., and Kilpatrick D.C. Mannan-binding lectin insufficiency in children with recurrent infections of the respiratory system. Clin. Exp. Immunol. 136 (2004) 304-311
2. Chomczynski P. A reagent for single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques 3 (1993) 532-537
3. Duncan R.C., Wijeyewickrema L.C., and Pike R.N. The initiating proteases of the complement system: controlling the cleavage. Biochimie 90 (2008) 387-395
4. Gal P., Barna L., Kocsis A., and Zavodszky P. Serine proteases of the classical and lectin pathways: similarities and differences. Immunobiology 212 (2007) 267-277
5. Gal P., Harmat V., Kocsis A., Bian T., Barna L., Ambrus G., Vegh B., Balczer J., Sim R.B., Naray-Szabo G., and Závodszky P. A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations. J. Biol. Chem. 280 (2005) 33435-33444
6. Garcia-Laorden M.I., Garcia-Saavedra A., De Castro F.R., Violan J.S., Rajas O., Blanquer J., and Rodriguez-Gallego C. Low clinical penetrance of mannose-binding lectin-associated serine protease 2 deficiency. J. Allergy Clin. Immunol. 118 (2006) 1383-1386
7. Garcia-Laorden M., Sole-Violan J., de Castro F., Aspa J., Briones M., Garcia-Saavedra A., Rajas O., Blanquer J., Caballero-Hidalgo A., and Marcos-Ramos J. Mannose-binding lectin and mannose-binding lectin-associated serine protease 2 in susceptibility, severity, and outcome of pneumonia in adults. J. Allergy Clin. Immunol. 122 (2008) 368-374.e2
8. Hajela K., Kojima M., Ambrus G., Wong N.K.H., Moffatt B.E., Ferluga J., Hajela S., Gal P., and Sim R. The biological functions of MBL-associated serine proteases (MASPs). Immunobiology 205 (2002) 467-475
9. Iwaki D., Kanno K., Takahashi M., Endo Y., Lynch N.J., Schwaeble W.J., Matsushita M., Okabe M., and Fujita T. Small mannose-binding lectin-associated protein plays a regulatory role in the lectin complement pathway. J. Immunol. 177 (2006) 8626-8632
10. Kemp A.S., and Campbell D.E. The neonatal immune system. Semin. Neonatal. 1 (1997) 67-75
11. Kerr F.K., Thomas A.R., Wijeyewickrema L.C., Whisstock J.C., Boyd S.E., Kaiserman D., Matthews A.Y., Bird P.I., Thielens N.M., Rossi V., and Pike R.N. Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor. Mol. Immunol. 45 (2008) 670-677
12. Kilpatrick D.C. Clinical significance of mannan-binding lectin and L-ficolin. In: Kilpatrick D. (Ed). Collagen-related Lectins in Innate Immunity (2007), Research Signpost, Trivandrum 57-84
13. Krarup A., Wallis R., Presanis J.S., Gal P., and Sim R.B. Simultaneous activation of complement and coagulation by MBL-associated serine protease 2. PLoS One 7 (2007) e623
14. Matsushita M., Thiel S., Jensenius J.C., Terai I., and Fujita T. Proteolytic activities of two types of mannose-binding lectin-associated serine protease. J. Immunol. 165 (2000) 2637-2642
15. Mayilyan K.R., Presanis J.S., Arnold J.N., Hajela K., and Sim R.B. Heterogeneity of MBL-MASP complexes. Mol. Immunol. 43 (2006) 1286-1292
16. Messias-Reason I., Bosco D.G., Nisihara R.M., Jakobsen L.H., Petzl-Erler M.L., and Jensenius J.C. Circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease 2 in endemic pemphigus foliaceus. Clin. Exp. Dermatol. 33 (2008) 495-497
17. Moller-Kristensen M., Jensenius J.Ch., Jensen L., Thielens N., Rossi V., Arlaud G., and Thiel S. Levels of mannan-binding lectin-associated serine protease 2 in healthy individuals. J. Immunol. Methods 282 (2003) 159-167
18. Moller-Kristensen M., Thiel S., Sjoholm A., Mastushita M., and Jensenius J.C. Cooperation between MASP-1 and MASP-2 in the generation of C3 conevertase trough the MBL pathway. Int. Immunol. 19 (2007) 141-149
19. Petersen S.V., Thiel S., Jensen L., Vorup-Jensen T., Koch C., and Jensenius J.C. Control of the classical and the MBL pathway of complement activation. Mol. Immunol. 37 (2000) 803-811
20. Presanis J.S., Hajela K., Ambrus G., Gal P., and Sim R.B. Differential substrate and inhibitor profiles for human MASP-1 and MASP-2. Mol. Immunol. 40 (2004) 921-929
21. Ramasawmy R., Spina G.S., Fae K.C., Pereira A.C., Nisihara R., Messias Reason I.J., Grinberg M., Tarasoutchi F., Kalil J., and Guilherme L. Association of mannose-binding lectin gene polymorphism but not of mannose-binding serine protease 2 with chronic severe aortic regurgitation of rheumatic etiology. Clin. Vaccine Immunol. 15 (2008) 932-936
22. Rossi V., Cseh S., Bally L., Thielens N.M., Jensenius J.C., and Arlaud G.J. Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2. J. Biol. Chem. 276 (2001) 40880-40887
23. Schlapbach L.J., Aebi C., Fisch U., Ammann R.A., Otth M., Bigler S., Nelle M., Berger S., and Kessler U. Higher cord blood levels of mannose-binding lectin-associated serine protease-2 in infants with necrotising enterocolitis. Pediatr. Res. 64 (2008) 562-566
24. Stengaard-Pedersen K., Thiel S., Gadjeva M., Moller-Kristensen M., Soresnsen R., Jensen L.T., Sjoholm A.G., Fugger L., and Jensenius J.C. Inherited deficiency of mannan-binding lectin-associated serine protease 2. NEJM 349 (2003) 554-560
25. Swierzko A.St., Atkinson A.P.M., Cedzynski M., MacDonald S.L., Szala A., Domzalska-Popadiuk I., Borkowska-Klos M., Jopek A., Szczapa J., Matsushita M., Szemraj J., Turner M.L., and Kilpatrick D.C. Two factors of the lectin pathway of complement, L-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates. Mol. Immunol. 46 (2009) 551-558
26. Takahashi M., Iwaki D., Kanno K., Ishida Y., Xiong J., Matsushita M., Endo Y., Miura S., Ishii N., Sugamura K., and Fujita T. Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway. J. Immunol. 180 (2008) 6132-6138
27. Terai I., Kobayashi K., Matsushita M., and Fujita T. Human serum mannose-binding lectin (MBL)-associated serine protease-1 (MASP-1): determination of levels in body fluids and identification of two forms in serum. Clin. Exp. Immunol. 110 (1997) 317-323
28. Thiel S. Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated serine proteases. Mol. Immunol. 44 (2007) 3875-3888
29. Thiel S., Petersen S.V., Vorup-Jensen T., Matsushita M., Fujita T., Stover C.M., Schwaeble W.J., and Jensenius J.C. Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine proteases 1 and 2, and the MBL-associated protein MAp19. J. Immunol. 165 (2000) 878-887
30. Thiel S., Steffensen R., Christensen I.J., Ip W.K., Lau Y.L., Reason I.J.M., Eiberg H., Gadjeva M., Ruseva M., and Jensenius J.C. Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms. Genes Immun. 8 (2007) 154-163