Cancer incidence among pesticide applicators exposed to permethrin in the Agricultural Health Study

Environmental Health Perspectives

Volumn 117, Issue 4, 2009, Pages 581-586

  Rusiecki, Jennifer A ^a   Patel, Rahulkumar ^a   Koutros, Stella ^b   Beane Freeman, Laura ^b   Landgren, Ola ^b   Bonner, Matthew R ^c   Coble, Joseph ^b   Lubin, Jay ^b   Blair, Aaron ^b   Hoppin, Jane A ^d   Alavanja, Michael C R ^b  

^a Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Agriculture; Cancer; Multiple myeloma; Occupation; Permethrin; Pesticide applicator; Pesticides; Pyrethroid

Indexed keywords

ALDICARB; CHLOROTHALONIL; COUMAFOS; METRIFONATE; PERMETHRIN; ZIRAM;

ADULT; AGED; AGRICULTURAL WORKER; ARTICLE; CANCER INCIDENCE; CANCER RISK; COLON CANCER; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; LEUKEMIA; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; MALIGNANT NEOPLASTIC DISEASE; MELANOMA; MULTIPLE MYELOMA; NONHODGKIN LYMPHOMA; OCCUPATIONAL CANCER; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROSTATE CANCER; QUESTIONNAIRE; RECTUM CANCER; RISK ASSESSMENT; SELF REPORT; UNITED STATES;

ADULT; FEMALE; HUMANS; INCIDENCE; INSECTICIDES; IOWA; MALE; MIDDLE AGED; NEOPLASMS; NORTH CAROLINA; OCCUPATIONAL EXPOSURE; PERMETHRIN;

EID: 64049117839     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.11318     Document Type: Article

References (48)

1. Agency for Toxic Substances and Disease Registry. 2003. Toxicological Profile for Pyrethrins and Pyrethroids. Atlanta, GA:U.S. Agency for Toxic Substances and Disease Registry.
2. Alavanja MC, Dosemeci M, Samanic C, Lubin J, Lynch CF, Knott C, et al. 2004. Pesticides and lung cancer risk in the Agricultural Health Study cohort. Am J Epidemiol 160(9):876-885.
3. Alavanja MC, Samanic C, Dosemeci M, Lubin J, Tarone R, Lynch CF, et al. 2003. Use of agricultural pesticides and prostate cancer risk in the Agricultural Health Study cohort. Am J Epidemiol 157(9):800-814.
4. Alavanja MC, Sandler DP, McDonnell CJ, Lynch CF, Pennybacker M, Zahm SH, et al. 1999. Characteristics of pesticide use in a pesticide applicator cohort: the Agricultural Health Study. Environ Res 80(2 pt 1):172-179.
5. Alavanja MC, Sandler DP, McMaster SB, Zahm SH, McDonnell CJ, Lynch CF, et al. 1996. The Agricultural Health Study. Environ Health Perspect 104:362-369.
6. Blair A, Stewart PA, Korss B, Ogilvie L, Burmeister LF, Ward MH, et al. 1997. Comparison of two techniques to obtain information on pesticide use from Iowa farmers by interview. J Agric Saf Health 3(4):229-236.
7. Blair A, Tarone R, Sandler D, Lynch CF, Rowland A, Wintersteen W, et al. 2002. Reliability of reporting on life-style and agricultural factors by a sample of participants in the Agricultural Health Study from Iowa. Epidemiology 13(1):94-99.
8. Blair A, Zahm SH. 1993. Patterns of pesticide use among farmers: implications for epidemiologic research. Epidemiology 4:55-62.
9. Blair A, Zahm SH, Pearce NE, Heineman EF, Fraumeni JF. 1992. Clues to cancer etiology from studies of farmers. Scand J Work Environ Health 18(4):209-215.
10. Chen H, Xiao J, Hu G, Zhou J, Xiao H, Wang X. 2002. Estrogenicity of organophosphorus and pyrethroid pesticides. J Toxicol Environ Health A 65(19):1419-1435.
11. Coble J, Hoppin JA, Engel L, Elci OC, Dosemeci M, Lynch CF, et al. 2002. Prevalence of exposure to solvents, metals, grain dust, and other hazards among farmers in the Agricultural Health Study. J Expo Anal Environ Epidemiol 12(6):418-426.
12. De Roos AJ, Blair A, Rusiecki JA, Hoppin JA, Svec M, Dosemeci M, et al. 2005. Cancer incidence among glyphosate-exposed pesticide applicators in the Agricultural Health Study. Environ Health Perspect 113:49-54.
13. Dosemeci M, Alavanja MC, Rowland AS, Mage D, Zahm SH, Rothman N, et al. 2002. A quantitative approach for estimating exposure to pesticides in the Agricultural Health Study. Ann Occup Hyg 46(2):245-260.
14. el-Toukhy MA, Ebied SA, Hassan AA, el-Sewedy SM. 1989. In vivo studies on the effect of some insecticides on the hepatic activities of L-tryptophan 2,3-dioxygenase and pyridoxal phosphokinase of male mice. J Environ Sci Health B 24(3):265-276.
15. Engel LS, Hill DA, Hoppin JA, Lubin JH, Lynch CF, Pierce J, et al. 2005. Pesticide use and breast cancer risk among farmers' wives in the Agricultural Health Study. Am J Epidemiol 161(2):121-135.
16. Food and Drug Administration. 2004. Pesticide Program Residue Monitoring 2002. Food and Drug Administration, Center for Food Safety and Nutrition. Available: http://www.cfsan.fda.gov/~dms/pes02rep.html [accessed 11 June 2008].
17. Gabbianelli R, Nasuti C, Falcioni G, Cantalamessa F. 2004. Lymphocyte DNA damage in rats exposed to pyrethroids: effect of supplementation with vitamins E and C. Toxicology 203(1-3):17-26.
18. Go V, Garey J, Wolff MS, Pogo BG. 1999. Estrogenic potential of certain pyrethroid compounds in the MCF-7 human breast carcinoma cell line. Environ Health Perspect 107:173-177.
19. Hakoi K, Cabral R, Hoshiya T, Hasegawa R, Shirai T, Ito N. 1992. Analysis of carcinogenic activity of some pesticides in a medium-term liver bioassay in the rat. Teratog Carcinog Mutagen 12(6):269-276.
20. Hideshima T, Mitsiades C, Tonon G, Richardson PG, Anderson KC. 2007. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat Rev Cancer 7(8):585-598.
21. Hoppin JA, Umbach DM, London SJ, Alavanja MC, Sandler DP. 2002. Chemical predictors of wheeze among farmer pesticide applicators in the Agricultural Health Study. Am J Respir Crit Care Med 165(5):683-689.
22. International Agency for Research on Cancer. 1991. Occupational Exposure Summary of Data Reported and Evaluation. IARC Monogr Eval Carcinog Risk Hum 53.
23. Ishmael J, Lithfield M. 1988. Chronic toxicity and carcinogenic evaluation of permethrin in rats and mice. Fundam Appl Toxicol 11(2):308-322.
24. Kakko I, Toimela T, Tahti H. 2004. Oestradiol potentiates the effects of certain pyrethroid compounds in the MCF7 human breast carcinoma cell line. Altern Lab Anim 32(4):383-390.
25. Kim IY, Han SY, Kang TS, Lee BM, Choi KS, Moon HJ, et al. 2005. Pyrethroid insecticides, fenvalerate and permethrin, inhibit progesterone-induced alkaline phosphatase activity in T47D human breast cancer cells. J Toxicol Environ Health A 68(23-24):2175-2186.
26. Kim IY, Shin JH, Kim HS, Lee SJ, Kang IH, Kim TS, et al. 2004. Assessing estrogenic activity of pyrethroid insecticides using in vitro combination assays. J Reprod Dev 50(2):245-255.
27. Kyle RA, Rajkumar SV. 2004. Multiple myeloma. N Engl J Med 351(18):1860-1873.
28. Kyle RA, Therneau TM, Rajkumar SV, Offord JR, Larson DR, Plevak MF, et al. 2002. A long-term study of prognosis in monoclonal gammopathy of undetermined significance. N Engl J Med 346(8):564-569.
29. Landgren O, Gridley G, Turesson I, Caporaso NE, Goldin LR, Baris D, et al. 2006. Risk of monoclonal gammopathy of undetermined significance (MGUS) and subsequent multiple myeloma among African American and white veterans in the United States. Blood 107(3):904-906.
30. Landgren O, Kyle RA. 2007. Multiple myeloma, chronic lymphocytic leukaemia and associated precursor diseases. Br J Haematol 139(5):717-723.
31. Lee WJ, Sandler DP, Blair A, Samanic C, Cross AJ, Alavanja MC. 2007. Pesticide use and colorectal cancer risk in the Agricultural Health Study. Int J Cancer 121(2):339-346.
32. Leithe E, Sirnes S, Omori Y, Rivedal E. 2006. Downregulation of gap junctions in cancer cells. Crit Rev Oncog 12(3-4):225-256.
33. Macedo PA, Peterson RK, Davis RS. 2007. Risk assessments for exposure of deployed military personnel to insecticides and personal protective measures used for disease-vector management. J Toxicol Environ Health A 70(20):1758-1771.
34. National Institutes of Health. 2008. Agricultural Health Study Homepage. Available: http://www.aghealth.org [accessed 1 October 2008].
35. National Pesticide Telecommunications Network. 1997. Permethrin Fact Sheet. Corvallis, OR:Oregon State University.
36. NRC (National Research Council). 1994. Health Effects of Permethrin-Impregnated Army Battle-Dress Uniforms. Washington, DC:National Academies Press.
37. Price RJ, Walters DG, Finch JM, Gabriel KL, Capen CC, Osimitz TG, et al. 2007. A mode of action for induction of liver tumors by pyrethrins in the rat. Toxicol Appl Pharmacol 218(2):186-195.
38. Rajkumar SV. 2005. MGUS and smoldering multiple myeloma: update on pathogenesis, natural history, and management. Hematol Am Soc Hematol Educ Program 340-345.
39. Rusiecki JA, De Roos A, Lee WJ, Dosemeci M, Lubin J, Hoppin JA, et al. 2004. Cancer Incidence among pesticide applicators exposed to atrazine in the Agricultural Health Study. J Natl Cancer Inst 96(18):1375-1382.
40. Swaine H, Tandy M, eds. 1984. Permethrin. New York:Academic Press.
41. Tateno C, Ito S, Tanaka M, Yoshitake A. 1993. Effects of pyrethroid insecticides on gap junctional intercellular communications in Balb/c3T3 cells by dye-transfer assay. Cell Biol Toxicol 9(3):215-221.
42. Tisch M, Schmezer P, Faulde M, Groh A, Maier H. 2002. Genotoxicity studies on permethrin, DEET and diazinon in primary human nasal mucosal cells. Eur Arch Otorhinolaryngol 259(3):150-153.
43. U.S. Department of Defense. 2002. Personal Protective Measures against Insects and Other Arthropods of Military Significance. Washington, DC:Walter Reed Army Medical Center.
44. U.S. EPA. 2006. Permethrin Facts (Reregistration Eligibility Decision (RED) Fact Sheet). Available: http://www.epa.gov/oppsrrd1/REDs/ factsheets/permethrin_fs.htm [accessed 11 June 2008].
45. U.S. EPA. 2007. Chemicals Evaluated for Carcinogenic Potential by the Office of Pesticide Programs. Washington, DC:Health Effects Division, Office of Pesticide Programs, U.S. Environmental Protection Agency.
46. Whitmore R, Kelly J, Reading P. 1992. National Home and Garden Pesticide Use Survey. Final Report. Vol 1: Executive Summary, Results, and Recommendations. Research Triangle Park, NC:Research Triangle Institute.
47. World Health Organization. 1990. International Classification of Diseases for Oncology, 2nd Revision. Geneva:World Health Organization.
48. Young G, Evans S. 1998. Safety and efficacy of DEET and permethrin in the prevention of arthropod attack. Mil Med 163:324-330.