Interleukin-1β production by Zygosaccharomyces bailii [pZ3 KlIL-1β] in aerated fed-batch reactor: Importance of inoculum physiology and bioprocess modelling

Process Biochemistry

Volumn 44, Issue 5, 2009, Pages 527-533

  Romano, Vittorio ^a   Paciello, Lucia ^a   Romano, Franca ^b   de Alteriis, Elisabetta ^b   Brambilla, Luca ^c   Parascandola, Palma ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Fed batch; Heterologous protein production; Interleukin; Mathematical model; Yeast; Zygosaccharomyces bailii

Indexed keywords

BATCH OPERATIONS; BIOPROCESS; BIOPROCESS MODELLING; CHARACTERISATION; CULTURAL SYSTEMS; EXPERIMENTAL APPROACHES; EXPERIMENTAL DATUM; EXPONENTIAL GROWTHS; FED-BATCH; FED-BATCH REACTORS; HETEROLOGOUS PROTEIN PRODUCTION; HIGH CELL DENSITIES; HUMAN INTERLEUKINS; INTERLEUKIN; INTERLEUKIN-1; OPTIMISATION; OVERFLOW METABOLISMS; OXYGEN TRANSFERS; PHYSIOLOGICAL STATE; ZYGOSACCHAROMYCES BAILII;

ANIMAL CELL CULTURE; BATCH REACTORS; BIOCHEMISTRY; COMPUTER SIMULATION; OXYGEN; PHYSIOLOGY; SUGAR (SUCROSE); SUGARS; YEAST;

MATHEMATICAL MODELS;

ZYGOSACCHAROMYCES; ZYGOSACCHAROMYCES BAILII;

EID: 64049115866     PISSN: 13595113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.procbio.2009.01.004     Document Type: Article

References (25)

1. Nielsen J. Microbial process kinetics. In: Ratledge C., and Kristiansen B. (Eds). Basic biotechnology (2001), Cambridge University Press 127-149
2. Branduardi P., Valli M., Brambilla L., Sauer M., Alberghina L., and Porro D. The yeast Zygosaccharomyces bailii: a new host for heterologous protein production, secretion and for metabolic engineering applications. FEMS Yeast Res 4 (2004) 493-504
3. Sousa Dias S., Gonçalves T., Leyva J.S., Peinado J.M., and Loureiro-Dias M.C. Kinetics and regulation of fructose and glucose transport systems are responsible for fructophily in Zygosaccharomyces bailii. Microbiology 142 (1996) 1733-1738
4. Cole M.B., and Keenan M.H. Synergistic effects of weak-acid preservatives and pH on the growth of Zygosaccharomyces bailii. Yeast 2 (1986) 93-100
5. Makdesi A.K., and Beuchat L.R. Improved selective medium for enumeration of benzoate-resistant, heat-stressed Zygosaccharomyces bailii. Int J Food Microbiol 33 (1996) 169-181
6. Merico A., Capitanio D., Vigentini I., Ranzi B.M., and Compagno C. Aerobic sugar metabolism in the spoilage yeast Zygosaccharomyces bailii. FEMS Yeast Res 4 (2003) 277-283
7. Fiechter A., Fuhrmann G.F., and Kappeli O. Regulation of glucose metabolism in growing yeast cells. Adv Microb Physiol 22 (1981) 123-183
8. Mendoza-Vega O., Sabatiè J., and Brown S.W. Industrial production of heterologous proteins by fed-batch cultures of the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev 15 (1994) 369-410
9. Enfors S.O. Baker's yeast. In: Ratledge C., and Kristiansen B. (Eds). Basic biotechnology (2001), Cambridge University Press 377-389
10. Bailey J.E., and Ollis D.F. Kinetics of substrate utilization, product formation, and biomass production in cell cultures. Biochemical engineering fundamentals (1986), McGraw-Hill, New York p. 373-456
11. Lee J., Lee S.Y., and Park S. Middelberg APJ Control of fed-batch fermentation. Biotechnol Adv 17 (1999) 29-48
12. Preuβ K., Le Lanne M.V., Proth J., and Pingaud H. Modelling and predictive control of fed-batch yeast growth on industrial pilot plant scale. Chem Eng J 78 (2000) 53-59
13. Di Serio M., and Tesser R. Santacesaria E A kinetic and mass transfer model to simulate the growth of baker's yeast in industrial bioreactors. Chem Eng J 82 (2001) 347-354
14. Maurer M., Kuhleitner M., Gasser B., and Mattanovich. D Versatile modeling and optimization of fed-batch processes for the production of secreted heterologous proteins with Pichia pastoris. Microb Cell Factories 5 (2006) 37-46
15. Pham H.T.B., Larsson G., and Enfors S.O. Growth and energy metabolism in aerobic fed-batch cultures of Saccharomyces cerevisiae: simulation and model verification. Biotechnol Bioeng 60 (1998) 473-482
16. 2 production by the food spoilage yeast Zygosaccharomyces bailii. Enzyme Microb Technol 24 (1999) 270-275
17. Enfors S.O., and Haggstrom L. Mass transport in bioreactors. Bioprocess technology, fundamentals and applications (1998), Hogskoletryckeriet, Stockolm p. 79-100
18. Nelson N.A. Photometric adaptation of the Somogyi method for the determination of glucose. J Biol Chem 153 (1944) 75-380
19. Vigentini I., Brambilla L., Branduardi P., Merico A., Porro D., and Compagno C. Heterologous protein production in Zygosaccharomyces bailii: physiological effects and fermentative strategies. FEMS Yeast Res 5 (2005) 647-652
20. Livense JC, Lim HC. The growth and dynamics of Saccharomyces cerevisiae. In: GT Tsao Editors. Annual reports on fermentation processes. 1982; 5: 211-262.
21. Gorgens J.F., van Zyl W.H., Knoetze J.H., and Hahn-Hägerdal B. The metabolic burden of the PGK1 and ADH2 promoter systems for heterologous xylanase production by Saccharomyces cerevisiae in defined medium. Biotechnol Bioeng 73 (2001) 238-245
22. Y'epez Silva-Santisteban B.O., and Maugeri Filho F. Agitation, aeration and shear stress as key factors in inulinase production by Kluyveromyces marxianus. Enzyme Microb Technol 36 (2005) 717-724
23. Madeo F., Fröhlich E., Ligr M., Grey M., Sigrist S.J., Wolf D.H., and Fröhlich K.U. Oxygen stress: a regulator of apoptosis in yeast. J Cell Biol 145 (1999) 757-767
24. Pronk J.T. Auxotrophic yeast strains in fundamental and applied research. Appl Environ Microbiol 68 (2002) 2095-2100
25. Romano V., Paciello L., Parascandola P., Palermo V., Mazzoni C., Falcone C., and de Alteriis E. Heterologous protein production by yeast in aerated fed-batch cultures: relevance of the host strain viability. Chem Eng Trans 14 (2008) 75-82