Induction of DNA Double-Strand Breaks and Cellular Migration Through Bystander Effects in Cells Irradiated With the Slit-Type Microplanar Beam of the Spring-8 Synchrotron

International Journal of Radiation Oncology Biology Physics

Volumn 74, Issue 1, 2009, Pages 229-236

  Kashino, Genro ^a   Kondoh, Takeshi ^b   Nariyama, Nobuteru ^c   Umetani, Keiji ^c   Ohigashi, Takuji ^c   Shinohara, Kunio ^c,d   Kurihara, Ai ^e   Fukumoto, Manabu ^e   Tanaka, Hiroki ^a   Maruhashi, Akira ^a   Suzuki, Minoru ^a   Kinashi, Yuko ^a   Liu, Yong ^a   Masunaga, Shin ichiro ^a   Watanabe, Masami ^a   Ono, Koji ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c JAPAN SYNCHROTRON RADIATION RESEARCH INSTITUTE   (Japan)

^d WASEDA UNIVERSITY   (Japan)

^e TOHOKU UNIVERSITY   (Japan)

Author keywords

Bystander effect; Cellular migration; DNA double strand breaks; Radiotherapy; Slit microbeam

Indexed keywords

BEAM IRRADIATIONS; BYSTANDER EFFECT; CELL POPULATIONS; CELLULAR MIGRATION; CONDITIONED MEDIUMS; CULTURE MEDIUMS; DAMAGED CELLS; DOSE DISTRIBUTIONS; FLUORESCENCE INTENSITIES; GLIOMA CELLS; IN CELLS; IN CONTROLS; IN-VITRO; NON-IRRADIATED CELLS; PEAK DOSE; SCATTERED X-RAYS; SINGLE BEAMS; SLIT MICROBEAM; SPRING-8; SYNCHROTRON RADIATION FACILITIES; X-RAY BEAMS;

CELL PROLIFERATION; DNA; GENES; IRRADIATION; NUCLEIC ACIDS; PHOSPHORYLATION; RADIOTHERAPY; SYNCHROTRONS;

CELL CULTURE;

HISTONE H2AX;

ANIMAL CELL; ARTICLE; BYSTANDER EFFECT; CELL DAMAGE; CELL MIGRATION; CELL POPULATION; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; FLUORESCENCE; GLIOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIATION DOSE DISTRIBUTION; RAT; SIGNAL TRANSDUCTION; SYNCHROTRON; X IRRADIATION;

ANIMALS; BYSTANDER EFFECT; CELL MOVEMENT; CULTURE MEDIA, CONDITIONED; DNA BREAKS, DOUBLE-STRANDED; GLIOMA; HISTONES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEOPLASM PROTEINS; RADIOTHERAPY DOSAGE; RATS; SYNCHROTRONS; TUMOR CELLS, CULTURED;

EID: 64049115098     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.09.060     Document Type: Article

References (35)

1. Laissue J.A., Geiser G., Spanne P.O., et al. Neuropathology of ablation of rat gliosarcomas and contiguous brain tissues using a microplanar beam of synchrotron-wiggler-generated X rays. Int J Cancer 78 (1998) 360-654
2. Dilmanian F.A., Button T.M., Le Duc G., et al. Response of rat intracranial 9L gliosarcoma to microbeam radiation therapy. Neuro Oncol 4 (2002) 26-38
3. Dilmanian F.A., Qu Y., Liu S., et al. X-ray microbeams: Tumor therapy and central nervous system research. Nucl Instrum Methods Phys Res 548 (2005) 30-37
4. Nagasawa H., and Little J.B. Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Res 52 (1992) 6394-6396
5. Azzam E.I., de Toledo S.M., Gooding T., and Little J.B. Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiat Res 150 (1998) 497-504
6. Shao C., Furusawa Y., Aoki M., and Ando K. Role of gap junctional intercellular communication in radiation-induced bystander effects in human fibroblasts. Radiat Res 160 (2003) 318-323
7. Mothersill C., and Seymour C. Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. Int J Radiat Biol 71 (1997) 421-427
8. Shao C., Furusawa Y., Aoki M., et al. Nitric oxide-mediated bystander effect induced by heavy-ions in human salivary gland tumour cells. Int J Radiat Biol 78 (2002) 837-844
9. Shao C., Stewart V., Folkard M., et al. Nitric oxide-mediated signaling in the bystander response of individually targeted glioma cells. Cancer Res 63 (2003) 8437-8442
10. Shao C., Folkard M., Michael B.D., and Prise K.M. Targeted cytoplasmic irradiation induces bystander responses. Proc Natl Acad Sci USA 101 (2004) 13495-13500
11. Schettino G., Folkard M., Prise K.M., et al. Low-dose studies of bystander cell killing with targeted soft X rays. Radiat Res 160 (2003) 505-511
12. Schettino G., Folkard M., Michael D.B., and Prise K.M. Low-dose binary behavior of bystander cell killng after microbeam irradiation of a single cell with focused c(k) X-rays. Radiat Res 163 (2005) 332-336
13. Kashino G., Prise K.M., Schettino G., et al. Evidence for induction of DNA double strand breaks in the bystander response to targeted soft X-rays in CHO cells. Mutat Res 556 (2004) 209-215
14. Kashino G., Suzuki K., Matsuda N., et al. Radiation induced bystander signals are independent of DNA damage and DNA repair capacity of the irradiated cells. Mutat Res 619 (2007) 134-138
15. Ryan L.A., Smith R.W., Seymour C.B., and Mothersill C.E. Dilution of irradiated cell conditioned medium and the bystander effect. Radiat Res 169 (2008) 188-196
16. Yang H., Asaad N., and Held K.D. Medium-mediated intercellular communication is involved in bystander responses of X-ray-irradiated normal human fibroblasts. Oncogene 24 (2005) 2096-2103
17. Hamada N., Matsumoto H., Hara T., and Kobayashi Y. Intercellular and intracellular signaling pathways mediating ionizing radiation-induced bystander effects. J Radiat Res 48 (2007) 87-95
18. Rothkamm K., and Löbrich M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci U S A 100 (2003) 5057-5062
19. Burdak-Rothkamm S., Short S.C., Folkard M., et al. ATR-dependent radiation-induced gamma H2AX foci in bystander primary human astrocytes and glioma cells. Oncogene 25 (2006) 7336-7342
20. Huyen Y., Zgheib O., Ditullio Jr. R.A., et al. Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature 432 (2004) 406-411
21. Botuyan M.V., Lee J., Ward I.M., et al. Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell 127 (2006) 1361-1373
22. Ohno Y., Torikoshi M., Suzuki M., et al. Dose distribution of a 125 keV mean energy microplanar x-ray beam for basic studies on microbeam radiotherapy. Am Med Phys 35 (2008) 3252-3258
23. Nariyama N., Ohigashi T., Umetani K., et al. Spectromicroscopic film dosimetry for high-energy microbeam from synchrotronradiation. Appl Radiat Isot 67 (2009) 155-159
24. Yamada K., Yamaura J., Katoh M., et al. Fabrication of cultured oral gingiva by tissue engineering techniques without materials of animal origin. J Periodontol 77 (2006) 672-677
25. Suzuki M., Suzuki K., Kodama S., and Watanabe M. Phosphorylated histone H2AX foci persist on rejoined mitotic chromosomes in normal human diploid cells exposed to ionizing radiation. Radiat Res 165 (2006) 269-276
26. Suzuki K., Okada H., Yamauchi M., et al. Qualitative and quantitative analysis of phosphorylated ATM foci induced by low-dose ionizing radiation. Radiat Res 165 (2006) 499-504
27. Yamauchi M., Oka Y., Yamamoto M., et al. Growth of persistent foci of DNA damage checkpoint factors is essential for amplification of G1 checkpoint signaling. DNA Repair 7 (2008) 405-417
28. Kashino G., Prise K.M., Suzuki K., et al. Effective suppression of bystander effects by DMSO treatment of irradiated CHO cells. J Radiat Res 48 (2007) 327-333
29. Anscher M.S., Crocker I.R., and Jirtle R.L. Transforming growth factor-β1 expression in irradiated liver. Radiat Res 122 (1990) 77-85
30. Barcellos-Hoff M.H. Radiation-induced transforming growth factor β and subsequent extracellular matrix reorganization in murine mammary gland. Cancer Res 53 (1993) 3880-3886
31. Iyer R., Lehnert B.E., and Svensson R. Factors underlying the cell growth-related bystander responses to alpha particles. Cancer Res 60 (2000) 1290-1298
32. Shao C., Folkard M., and Prise K.M. Role of TGF-beta1 and nitric oxide in the bystander response of irradiated glioma cells. Oncogene 27 (2008) 434-440
33. Tian Y.C., Chen Y.C., Chang C.T., et al. Epidermal growth factor and transforming growth factor-beta1 enhance HK-2 cell migration through a synergistic increase of matrix metalloproteinase and sustained activation of ERK signaling pathway. Exp Cell Res 313 (2007) 2367-2377
34. Ward I.M., and Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem 276 (2001) 47759-47762
35. Stiff T., Walker S.A., Cerosaletti K., et al. ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J 25 (2006) 5775-5782