Effects of vitamin C on hyperoxia-induced reduction of retinal blood flow

Microvascular Research

Volumn 77, Issue 3, 2009, Pages 256-259

  Weigert, Günther ^a   Luksch, Alexandra ^a   Maár, Noemi ^a   Sacu, Stefan ^a   Schmetterer, Leopold ^a   Garhöfer, Gerhard ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Hyperoxia; Retinal blood flow; Vitamin C

Indexed keywords

ASCORBIC ACID; OXYGEN; REACTIVE OXYGEN METABOLITE;

ANTIOXIDANT ACTIVITY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; ERYTHROCYTE; HEADACHE; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; HYPEROXIA; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETINA ARTERY; RETINA BLOOD FLOW; RETINA BLOOD VESSEL; VASOCONSTRICTION; VELOCITY;

ASCORBIC ACID; BLOOD FLOW VELOCITY; CHOROID; CROSS-OVER STUDIES; ERYTHROCYTES; HEMODYNAMICS; HUMANS; HYPEROXIA; INHALATION EXPOSURE; LASER-DOPPLER FLOWMETRY; OXYGEN; RETINAL VESSELS; VASOCONSTRICTION;

EID: 64049113734     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2008.12.002     Document Type: Article

References (24)

1. Cook N.R., Albert C.M., Gaziano J.M., Zaharris E., MacFadyen J., Danielson E., Buring J.E., and Manson J.E. A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study. Arch. Intern. Med. 167 (2007) 1610-1618
2. Dallinger S., Dorner G.T., Wenzel R., Graselli U., Findl O., Eichler H.G., Wolzt M., and Schmetterer L. Endothelin-1 contributes to hyperoxia-induced vasoconstriction in the human retina. Invest. Ophthalmol. Vis. Sci. 41 (2000) 864-869
3. Dorner G.T., Garhofer G., Kiss B., Polska E., Polak K., Riva C.E., and Schmetterer L. Nitric oxide regulates retinal vascular tone in man. Am. J. Physiol. Heart Circ. Physiol. 285 (2003) 631-636
4. Irani K. Oxidant signaling in vascular cell growth, death, and survival: a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling. Circ. Res. 87 (2000) 179-183
5. Izumi N., Nagaoka T., Sato E., Sogawa K., Kagokawa H., Takahashi A., Kawahara A., and Yoshida A. Role of nitric oxide in regulation of retinal blood flow in response to hyperoxia in cats. Invest. Ophthalmol. Vis. Sci. 49 (2008) 4595-4603
6. Jaimes E.A., Sweeney C., and Raij L. Effects of the reactive oxygen species hydrogen peroxide and hypochlorite on endothelial nitric oxide production. Hypertension 38 (2001) 877-883
7. Jean-Louis S., Lovasik J.V., and Kergoat H. Systemic hyperoxia and retinal vasomotor responses. Invest. Ophthalmol. Vis. Sci. 46 (2005) 1714-1720
8. Kiss B., Polska E., Dorner G., Polak K., Findl O., Mayrl G.F., Eichler H.G., Wolzt M., and Schmetterer L. Retinal blood flow during hyperoxia in humans revisited: concerted results using different measurement techniques. Microvasc. Res. 64 (2002) 75-85
9. Li Z.Y., Tso M.O., Wang H.M., and Organisciak D.T. Amelioration of photic injury in rat retina by ascorbic acid: a histopathologic study. Invest. Ophthalmol. Vis. Sci. 26 (1985) 1589-1598
10. Luksch A., Garhofer G., Imhof A., Polak K., Polska E., Dorner G.T., Anzenhofer S., Wolzt M., and Schmetterer L. Effect of inhalation of different mixtures of O(2) and CO(2) on retinal blood flow. Br. J. Ophthalmol. 86 (2002) 1143-1147
11. Machlin L.J., and Bendich A. Free radical tissue damage: protective role of antioxidant nutrients. FASEB J. 1 (1987) 441-445
12. Mak S., Egri Z., Tanna G., Colman R., and Newton G.E. Vitamin C prevents hyperoxia-mediated vasoconstriction and impairment of endothelium-dependent vasodilation. Am. J. Physiol. Heart Circ. Physiol. 282 (2002) H2414-H2421
13. Mares-Perlman J.A., Brady W.E., Klein R., Klein B.E., Bowen P., Stacewicz-Sapuntzakis M., and Palta M. Serum antioxidants and age-related macular degeneration in a population-based case-control study. Arch. Ophthalmol. 113 (1995) 1518-1523
14. Mares-Perlman J.A., Klein R., Klein B.E., Greger J.L., Brady W.E., Palta M., and Ritter L.L. Association of zinc and antioxidant nutrients with age-related maculopathy. Arch. Ophthalmol. 114 (1996) 991-997
15. McNulty P.H., Robertson B.J., Tulli M.A., Hess J., Harach L.A., Scott S., and Sinoway L.I. Effect of hyperoxia and vitamin C on coronary blood flow in patients with ischemic heart disease. J. Appl. Physiol. 102 (2007) 2040-2045
16. Meister A. Glutathione-ascorbic acid antioxidant system in animals. J. Biol. Chem. 269 (1994) 9397-9400
17. Organisciak D.T., Jiang Y.L., Wang H.M., and Bicknell I. The protective effect of ascorbic acid in retinal light damage of rats exposed to intermittent light. Invest. Ophthalmol. Vis. Sci. 31 (1990) 1195-1202
18. Riva C.E., Grunwald J.E., and Sinclair S.H. Laser Doppler Velocimetry study of the effect of pure oxygen breathing on retinal blood flow. Invest. Ophthalmol. Vis. Sci. 24 (1983) 47-51
19. Riva C.E., Grunwald J.E., Sinclair S.H., and Petrig B.L. Blood velocity and volumetric flow rate in human retinal vessels. Invest. Ophthalmol. Vis. Sci. 26 (1985) 1124-1132
20. Seddon J.M., Ajani U.A., Sperduto R.D., Hiller R., Blair N., Burton T.C., Farber M.D., Gragoudas E.S., Haller J., Miller D.T., et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. JAMA 272 (1994) 1413-1420
21. Stadtman E.R. Protein oxidation and aging. Free Radic. Res. 40 (2006) 1250-1258
22. Szabo C. The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury. Shock 6 (1996) 79-88
23. VandenLangenberg G.M., Mares-Perlman J.A., Klein R., Klein B.E., Brady W.E., and Palta M. Associations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye Study. Am. J. Epidemiol. 148 (1998) 204-214
24. West S., Vitale S., Hallfrisch J., Munoz B., Muller D., Bressler S., and Bressler N.M. Are antioxidants or supplements protective for age-related macular degeneration?. Arch. Ophthalmol. 112 (1994) 222-227