Aminoguanidine Alleviates Radiation-Induced Small-Bowel Damage Through Its Antioxidant Effect

International Journal of Radiation Oncology Biology Physics

Volumn 74, Issue 1, 2009, Pages 237-244

  Huang, Eng Yen ^a   Wang, Feng Sheng ^a   Lin, I Hui ^a   Yang, Kuender D ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Aminoguanidine; Antioxidant effect; Diarrhea; Irradiation; Small bowel

Indexed keywords

3-NITROTYROSINE; ABDOMINAL IRRADIATIONS; AMINOGUANIDINE; ANTIOXIDANT EFFECT; DIARRHEA; DOSE DEPENDENTS; IMMUNOHISTOCHEMISTRY; INDUCIBLE NITRIC-OXIDE SYNTHASE (INOS); NITROSATIVE STRESS; PORTAL VEINS; PROTECTIVE EFFECTS; SMALL BOWEL; SMALL INTESTINES; SPRAGUE-DAWLEY RATS;

IRRADIATION; NITRIC OXIDE; RATS; WINDOWS OPERATING SYSTEM;

COMPUTERIZED TOMOGRAPHY;

3 NITROTYROSINE; 8 HYDROXYDEOXYGUANOSINE; AMINOGUANIDINE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRATE; NITRIC OXIDE; NITRITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DIARRHEA; DOSE RESPONSE; DRUG MECHANISM; IMMUNOHISTOCHEMISTRY; INTESTINE CRYPT; INTESTINE INJURY; MALE; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PORTAL VEIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION INJURY; RADIATION PROTECTION; RAT;

ANIMALS; ANTIOXIDANTS; DEOXYGUANOSINE; DIARRHEA; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANIDINES; HELA CELLS; HUMANS; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; NITRATES; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; OXIDATIVE STRESS; RADIATION INJURIES; RADIATION-PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; TYROSINE;

EID: 64049107876     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.01.017     Document Type: Article

References (29)

1. Pia de la Maza M., Gotteland M., Ramirez C., et al. Acute nutritional and intestinal changes after pelvic radiation. J Am Coll Nutr 20 (2001) 637-642
2. Somosy Z., Horvath G., Telbisz A., et al. Morphological aspects of ionizing radiation response of small intestine. Micron 33 (2002) 167-178
3. Huang E.Y., Hsu H.C., Yang K.D., et al. Acute diarrhea during pelvic irradiation: Is small-bowel volume effect different in gynecologic patients with prior abdomen operation or not?. Gynecol Oncol 97 (2005) 118-125
4. Huang E.Y., Sung C.C., Ko S.F., et al. The different volume effects of small-bowel toxicity during pelvic irradiation between gynecologic patients with and without abdominal surgery: A prospective study with computed tomography-based dosimetry. Int J Radiat Oncol Biol Phys 69 (2007) 732-739
5. Brownlee M., Vlassara H., Kooney A., et al. Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking. Science 232 (1986) 1629-1632
6. Bolton W.K., Cattran D.C., Williams M.E., et al. Randomized trial of an inhibitor of formation of advanced glycation end products in diabetic nephropathy. Am J Nephrol 24 (2004) 32-40
7. Corbett J.A., Tilton R.G., Chang K., et al. Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction. Diabetes 41 (1992) 552-556
8. Courderot-Masuyer C., Dalloz F., Maupoil V., et al. Antioxidant properties of aminoguanidine. Fundam Clin Pharmacol 13 (1999) 535-540
9. Mansour M.A., Mostafa A.M., Nagi M.N., et al. Protective effect of aminoguanidine against nephrotoxicity induced by cisplatin in normal rats. Comp Biochem Physiol C Toxicol Pharmacol 132 (2002) 123-128
10. Giardino I., Fard A.K., Hatchell D.L., et al. Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis. Diabetes 47 (1998) 1114-1120
11. Thornalley P.J. Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts. Arch Biochem Biophys 419 (2003) 31-40
12. Brown C.D., Zhao Z.H., Thomas L.L., et al. Effects of erythropoietin and aminoguanidine on red blood cell deformability in diabetic azotemic and uremic patients. Am J Kidney Dis 38 (2001) 1414-1420
13. Zeballos G.A., Bernstein R.D., Thompson C.I., et al. Pharmacodynamics of plasma nitrate/nitrite as an indication of nitric oxide formation in conscious dogs. Circulation 91 (1995) 2982-2988
14. Wang C.L., Wu Y.T., Lee C.J., et al. Decreased nitric oxide production after intravenous immunoglobulin treatment in patients with Kawasaki disease. J Pediatr 141 (2002) 560-565
15. Ruifrok A.C., Weil M.M., Mason K.A., et al. Induction of transforming growth factor alpha in irradiated mouse jejunum. Int J Radiat Oncol Biol Phys 42 (1998) 1137-1146
16. Brey E.M., Lalani Z., Johnston C., et al. Automated selection of DAB-labeled tissue for immunohistochemical quantification. J Histochem Cytochem 51 (2003) 575-584
17. Withers H.R., and Elkind M.M. Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation. Int J Radiat Biol Relat Stud Phys Chem Med 17 (1970) 261-267
18. Hall E.J. Cell survival curve. In: Hall E.J. (Ed). Radiobiology for the radiologist. 4th ed (1994), Lippincott, Philadephia 29-43
19. Potten C.S., Booth C., and Pritchard D.M. The intestinal epithelial stem cell: The mucosal governor. Int J Exp Pathol 78 (1997) 219-243
20. Potten C.S., Owen G., and Roberts S.A. The temporal and spatial changes in cell proliferation within the irradiated crypts of the murine small intestine. Int J Radiat Biol 57 (1990) 185-199
21. Baylin S., Horakova Z., and Beaven M.A. Increase in food consumption and growth after treatment with aminoguanidine. Experientia 31 (1975) 562-564
22. Wolff D.J., Gauld D.S., Neulander M.J., et al. Inactivation of nitric oxide synthase by substituted aminoguanidines and aminoisothioureas. J Pharmacol Exp Ther 283 (1997) 265-273
23. Boer R., Ulrich W.R., Klein T., et al. The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes. Mol Pharmacol 58 (2000) 1026-1034
24. Laszlo F., Evans S.M., and Whittle B.J. Aminoguanidine inhibits both constitutive and inducible nitric oxide synthase isoforms in rat intestinal microvasculature in vivo. Eur J Pharmacol 272 (1995) 169-175
25. Voevodskaya N.V., and Vanin A.F. Gamma-irradiation potentiates L-arginine-dependent nitric oxide formation in mice. Biochem Biophys Res Commun 186 (1992) 1423-1428
26. Freeman S.L., and MacNaughton W.K. Ionizing radiation induces iNOS-mediated epithelial dysfunction in the absence of an inflammatory response. Am J Physiol Gastrointest Liver Physiol 278 (2000) G243-G250
27. MacNaughton W.K., Aurora A.R., Bhamra J., et al. Expression, activity and cellular localization of inducible nitric oxide synthase in rat ileum and colon post-irradiation. Int J Radiat Biol 74 (1998) 255-264
28. Foote E.F., Look Z.M., Giles P., et al. The pharmacokinetics of aminoguanidine in end-stage renal disease patients on hemodialysis. Am J Kidney Dis 25 (1995) 420-425
29. Wang G.Y., Ji B., Wang X., et al. Anti-cancer effect of iNOS inhibitor and its correlation with angiogenesis in gastric cancer. World J Gastroenterol 11 (2005) 3830-3833