The role of the equilibrative nucleoside transporter 1 (ENT1) in transport and metabolism of ribavirin by human and wild-type or ent1(-/-) mouse erythrocytes

Journal of Pharmacology and Experimental Therapeutics

Volumn 329, Issue 1, 2009, Pages 387-398

  Endres, Christopher J ^a   Moss, Aaron M ^a   Ke, Ban ^a   Govindarajan, Rajgopal ^a   Choi, Doo Sup ^b   Messing, Robert O ^c   Unadkat, Jashvant D ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA SAN FRANCISCO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; ISOTOPE; RIBAVIRIN; RIBAVIRIN H 3; RIBAVIRIN MONOPHOSPHATE; RIBAVIRIN TRIPHOSPHATE; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DEGRADATION; DRUG DIFFUSION; DRUG DISPOSITION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG TRANSPORT; DRUG UPTAKE; ERYTHROCYTE; EX VIVO STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; ISOTOPE LABELING; MOUSE; NONHUMAN; NORMAL HUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RADIOACTIVITY; SIMULATION; TRANSPORT KINETICS;

ALGORITHMS; ANIMALS; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DATA INTERPRETATION, STATISTICAL; DNA, COMPLEMENTARY; DOGS; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; ERYTHROCYTES; HUMANS; KINETICS; MICE; MICE, KNOCKOUT; MODELS, STATISTICAL; RIBAVIRIN; THIOINOSINE; TRANSDUCTION, GENETIC;

EID: 64049096186     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.145854     Document Type: Article

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