Immunoglobulin M deposition in cutaneous nerves of anti-myelin-associated glycoprotein polyneuropathy patients correlates with axonal degeneration

Journal of Neuropathology and Experimental Neurology

Volumn 68, Issue 2, 2009, Pages 148-158

  Stalder, Anna K ^a   Erne, Beat ^a   Reimann, Regina ^a   Renaud, Susanne ^a   Fuhr, Peter ^a   Thomann, Sandra ^a   Arnold, Andreas ^a   Probst, Alphonse ^a   Schaeren Wiemers, Nicole ^a   Steck, Andreas J ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Anti MAG polyneuropathy; Axonal degeneration; Confocal microscopy; Immunoglobulin M deposition; Skin biopsy

Indexed keywords

CYCLOPHOSPHAMIDE; FLUDARABINE; IMMUNOGLOBULIN M; MYELIN ASSOCIATED GLYCOPROTEIN; RITUXIMAB; MAG PROTEIN, HUMAN; NEUROFILAMENT PROTEIN; TUMOR PROTEIN;

ADD ON THERAPY; ADULT; AGED; ANTIBODY TITER; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISEASE DURATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN DEPOSITION; MALE; NERVE CELL DEGENERATION; NERVE FIBER DEGENERATION; NERVE INJURY; NEUROFILAMENT; NEUROPATHOLOGY; PERINEURIUM; POLYNEUROPATHY; PRIORITY JOURNAL; SCHWANN CELL; SKIN BIOPSY; SKIN NERVE; ULTRASTRUCTURE ANALYSIS AND ELECTRON MICROSCOPY; BIOPSY; BLOOD; IMMUNOLOGY; INNERVATION; METABOLISM; MIDDLE AGED; MYELIN SHEATH; MYELINATED NERVE; NERVE DEGENERATION; PATHOLOGY; PATHOPHYSIOLOGY; PERIPHERAL NERVE; SENSORY RECEPTOR; SKIN; TRANSMISSION ELECTRON MICROSCOPY;

AGED; BIOPSY; FEMALE; HUMANS; IMMUNOGLOBULIN M; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; MYELIN SHEATH; NEOPLASM PROTEINS; NERVE FIBERS, MYELINATED; NEUROFILAMENT PROTEINS; PERIPHERAL NERVES; POLYNEUROPATHIES; SCHWANN CELLS; SENSORY RECEPTOR CELLS; SKIN; WALLERIAN DEGENERATION;

EID: 64049095103     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3181958187     Document Type: Article

References (37)

1. Smith IS, Kahn SN, Lacey BW, et al. Chronic demyelinating neuropathy associated with benign IgM paraproteinaemia. Brain 1983;106:169-195
2. Nobile-Orazio E. IgM paraproteinaemic neuropathies. Curr Opin Neurol 2004;17:599-605
3. Radziwill AJ, Steck AJ, Renaud S, et al. Distal motor latency and residual latency as sensitive markers of anti-MAG polyneuropathy. J Neurol 2003;250:962-966
4. Franssen H, Notermans NC. Length dependence in polyneuropathy associated with IgM gammopathy. Ann Neurol 2006;59:365-371
5. Lupu VD, Mora CA, Dambrosia J, et al. Terminal latency index in neuropathy with antibodies against myelin-associated glycoproteins. Muscle Nerve 2007;35:196-202
6. Steck AJ, Murray N, Justafre JC, et al. Passive transfer studies in demyelinating neuropathy with IgM monoclonal antibodies to myelin-associated glycoprotein. J Neurol Neurosurg Psychiatry 1985;48:927-929
7. Renaud S, Fuhr P, Gregor M, et al. High-dose rituximab and antiYMAG-associated polyneuropathy. Neurology 2006;66:742-744
8. Gabriel JM, Erne B, Bernasconi L, et al. Confocal microscopic localization of antiYmyelin-associated glycoprotein autoantibodies in a patient with peripheral neuropathy initially lacking a detectable IgM gammopathy. Acta Neuropathol (Berl) 1998;95:540-546
9. Gabriel JM, Erne B, Miescher GC, et al. Selective loss of myelin-associated glycoprotein from myelin correlates with anti-MAG antibody titre in demyelinating paraproteinaemic polyneuropathy. Brain 1996;119:775-787
10. Mendell JR, Sahenk Z, Whitaker JN, et al. Polyneuropathy and IgM monoclonal gammopathy: Studies on the pathogenetic role of antiYmyelin- associated glycoprotein antibody. Ann Neurol 1985;17: 243-254
11. Ellie E, Vital A, Steck A, et al. Neuropathy associated with Bbenign[ antiYmyelin-associated glycoprotein IgM gammopathy: Clinical, immunological, neurophysiological pathological findings and response to treatment in 33 cases. J Neurol 1996;243:34-43
12. Jacobs JM, Scadding JW. Morphological changes in IgM parapro-teinaemic neuropathy. Acta Neuropathol (Berl) 1990;80:77-84
13. Steck AJ, Stalder AK, Renaud S. AntiYmyelin-associated glycoprotein neuropathy. Curr Opin Neurol 2006;19:458-463
14. Lauria G, Cornblath DR, Johansson O, et al. EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy. Eur J Neurol 2005;12:747-758
15. Ebenezer GJ, McArthur JC, Thomas D, et al. Denervation of skin in neuropathies: The sequence of axonal and Schwann cell changes in skin biopsies. Brain 2007;130:2703-2714
16. Provitera V, Nolano M, Pagano A, et al. Myelinated nerve endings in human skin. Muscle Nerve 2007;35:767-775
17. Lombardi R, Erne B, Lauria G, et al. IgM deposits on skin nerves in antiYmyelin-associated glycoprotein neuropathy. Ann Neurol 2005;57: 180-187
18. McCarthy BG, Hsieh ST, Stocks A, et al. Cutaneous innervation in sensory neuropathies: Evaluation by skin biopsy. Neurology 1995;45: 1848-1855
19. Erb M, Flueck B, Kern F, et al. Unraveling the differential expression of the two isoforms of myelin-associated glycoprotein in a mouse expressing GFP-tagged S-MAG specifically regulated and targeted into the different myelin compartments. Mol Cell Neurosci 2006;31: 613-627
20. Burger D, Simon M, Perruisseau G, et al. The epitope(s) recognized by HNK-1 antibody and IgM paraprotein in neuropathy is present on several N-linked oligosaccharide structures on human P0 and myelin-associated glycoprotein. J Neurochem 1990;54:1569-1575
21. Perentes E, Nakagawa Y, Ross GW, et al. Expression of epithelial membrane antigen in perineurial cells and their derivatives. An immu-nohistochemical study with multiple markers. Acta Neuropathol (Berl) 1987;75:160-165
22. Ritz MF, Erne B, Ferracin F, et al. Anti-MAG IgM penetration into myelinated fibers correlates with the extent of myelin widening. Muscle Nerve 1999;22:1030-1037
23. Charles P, Tait S, Faivre-Sarrailh C, et al. Neurofascin is a glial receptor for the paranodin/Caspr-contactin axonal complex at the axoglial junction. Curr Biol 2002;12:217-220
24. Poliak S, Peles E. The local differentiation of myelinated axons at nodes of Ranvier. Nat Rev Neurosci 2003;4:968-980
25. Petzold A. Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss. J Neurol Sci 2005;233:183-198
26. Vital C, Vital A, Deminiere C, et al. Myelin modifications in 8 cases of peripheral neuropathy with Waldenstrom's macroglobulinemia and anti-MAG activity. Ultrastruct Pathol 1997;21:509-516
27. Kaku DA, England JD, Sumner AJ. Distal accentuation of conduction slowing in polyneuropathy associated with antibodies to myelinassociated glycoprotein and sulphated glucuronyl paragloboside. Brain 1994;117:941-947
28. Chassande B, Leger JM, Younes-Chennoufi AB, et al. Peripheral neuropathy associated with IgM monoclonal gammopathy: Correlations between M-protein antibody activity and clinical/electrophysiological features in 40 cases. Muscle Nerve 1998;21:55-62
29. Mata M, Kahn SN, Fink DJ. A direct electron microscopic immunocytochemical study of IgM paraproteinemic neuropathy. Arch Neurol 1988;45:693-697
30. Fluri F, Ferracin F, Erne B, et al. Microheterogeneity of antiYmyelinassociated glycoprotein antibodies. J Neurol Sci 2003;207:43-49
31. Ilyas AA, Gu Y, Dalakas MC, et al. Induction of experimental ataxic sensory neuronopathy in cats by immunization with purified SGPG. J Neuroimmunol 2008;193:87-93
32. Day IN. Enolases and PGP9.5 as tissue-specific markers. Biochem Soc Trans 1992;20:637-642
33. Howell OW, Palser A, Polito A, et al. Disruption of neurofascin localization reveals early changes preceding demyelination and remyeli-nation in multiple sclerosis. Brain 2006;129:3173-3185
34. Ohnishi A, Hirano A. Uncompacted myelin lamellae in dysglobulinemic neuropathy. J Neurol Sci 1981;51:131-140
35. Bosboom WM, Van den Berg LH, Dieks HJ, et al. Unmyelinated nerve fiber degeneration in chronic inflammatory demyelinating polyneuro-pathy. Acta Neuropathologica 2000;99:571-578
36. Levine TD, Pestronk A. IgM antibody-related polyneuropathies: B-Cell depletion chemotherapy using Rituximab. Neurology 1999;52:1701-1704
37. Renaud S, Gregor M, Fuhr P, et al. Rituximab in the treatment of polyneuropathy associated with anti-MAG antibodies. Muscle Nerve 2003;27:611-15