Genetically engineered yeasts as a new delivery vehicle of active compounds to the digestive tract: In vivo validation of the concept in the rat

Metabolic Engineering

Volumn 11, Issue 3, 2009, Pages 148-154

  Garrait, G ^a   Jarrige, J F ^a   Blanquet Diot, S ^a   Alric, M ^a  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

Author keywords

Biodrug; Digestive environment; Rat; Recombinant S. cerevisiae; Secretion

Indexed keywords

ACTIVE COMPOUNDS; BIODRUG; CONCEPT-BASED; DELIVERY VEHICLES; DIGESTIVE ENVIRONMENT; DIGESTIVE TRACTS; GLUTATHIONE S TRANSFERASE; IN-VIVO; LARGE INTESTINAL; MODEL PROTEINS; ORAL ADMINISTRATIONS; RECOMBINANT MICROORGANISMS; RECOMBINANT S. CEREVISIAE; RECOMBINANT YEASTS; SACCHAROMYCES CEREVISIAE STRAINS; SECRETION; SURVIVAL RATES; WESTERN-BLOT ANALYSIS;

AUTOMOBILE PARTS AND EQUIPMENT; MICROORGANISMS; SYSTEM THEORY; YEAST;

DIGESTIVE SYSTEM;

GENE THERAPY AGENT; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CECUM; CELL SURVIVAL; COLON; CONTROLLED STUDY; DIGESTIVE SYSTEM; DUODENUM; ENZYME ASSAY; EXPRESSION VECTOR; FUNGAL STRAIN; FUNGAL VIABILITY; GENETIC ENGINEERING; ILEUM; IN VIVO STUDY; JEJUNUM; LARGE INTESTINE; MALE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; SACCHAROMYCES CEREVISIAE; STOMACH; VALIDATION STUDY; WESTERN BLOTTING; ANIMAL; DRUG DELIVERY SYSTEM; GASTROINTESTINAL TRACT; MICROBIAL VIABILITY; MICROBIOLOGY; PHYSIOLOGY; WISTAR RAT;

ANIMALS; DRUG DELIVERY SYSTEMS; GASTROINTESTINAL TRACT; GENETIC ENGINEERING; GLUTATHIONE TRANSFERASE; MALE; MICROBIAL VIABILITY; RATS; RATS, WISTAR; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE;

RATTUS; SACCHAROMYCES CEREVISIAE;

EID: 63949086756     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2009.01.001     Document Type: Article

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