Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-κB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility

Arthritis Research and Therapy

Volumn 11, Issue 2, 2009, Pages

  Dieguez Gonzalez, Rebeca ^a   Calaza, Manuel ^a   Perez Pampin, Eva ^a   Balsa, Alejandro ^b   Blanco, Francisco J ^c   Cañete, Juan D ^d   Caliz, Rafael ^e   Carreño, Luis ^f   de la Serna, Arturo R ^g   Fernandez Gutierrez, Benjamin ^h   Ortiz, Ana ⁱ   Herrero Beaumont, Gabriel ^j   Pablos, Jose L ^k   Narvaez, Javier ^l   Navarro, Federico ^m   Marenco, Jose L ⁿ   Gomez Reino, Juan J ^a,o   Gonzalez, Antonio ^a  

^a Instituto de Salud Carlos III   (Spain)

^b HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^c HOSPITAL JUAN CANALEJO   (Spain)

^d HOSPITAL CLÍNIC   (Spain)

^e HOSPITAL UNIVERSITARIO VIRGEN DE LAS NIEVES   (Spain)

^f HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^g HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^h HOSPITAL CLÍNICO SAN CARLOS   (Spain)

ⁱ HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^j Hospital UniversitarioFundación Jiménez Díaz   (Spain)

^k HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^l HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^m HOSPITAL UNIVERSITARIO VIRGEN MACARENA   (Spain)

ⁿ HOSPITAL UNIVERSITARIO DE VALME   (Spain)

^o UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CITRULLINATED PEPTIDE ANTIBODY; I KAPPA B; PEPTIDE ANTIBODY; SPACER DNA; TUMOR NECROSIS FACTOR ALPHA INDUCED PROTEIN 3; UNCLASSIFIED DRUG; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NUCLEAR PROTEIN; SIGNAL PEPTIDE; TNFAIP3 PROTEIN, HUMAN;

ARTICLE; CHROMOSOME 6Q; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE FUNCTION; GENE INTERACTION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HEREDITY; HUMAN; MAJOR CLINICAL STUDY; PATHOGENESIS; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; SPAIN; SYSTEMIC LUPUS ERYTHEMATOSUS; CHROMOSOME 6; GENETIC PREDISPOSITION; GENETICS; METABOLISM; POLYMERASE CHAIN REACTION;

ARTHRITIS, RHEUMATOID; CHROMOSOMES, HUMAN, PAIR 6; DNA, INTERGENIC; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NF-KAPPA B; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 63849340940     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2650     Document Type: Article

References (22)

1. Wellcome Trust Case Control Consortium Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Nature 2007, 447:661-678. 10.1038/nature05911 17554300
2. Plenge RM Cotsapas C Davies L Price AL de Bakker PI Maller J Pe'er I Burtt NP Blumenstiel B DeFelice M Parkin M Barry R Winslow W Healy C Graham RR Neale BM Izmailova E Roubenoff R Parker AN Glass R Karlson EW Maher N Hafler DA Lee DM Seldin MF Remmers EF Lee AT Padyukov L Alfredsson L Coblyn J Two independent alleles at 6q23 associated with risk of rheumatoid arthritis Nat Genet 2007, 39:1477-1482. 2652744 17982456 10.1038/ng.2007.27
3. Plenge RM Seielstad M Padyukov L Lee AT Remmers EF Ding B Liew A Khalili H Chandrasekaran A Davies LR Li W Tan AK Bonnard C Ong RT Thalamuthu A Pettersson S Liu C Tian C Chen WV Carulli JP Beckman EM Altshuler D Alfredsson L Criswell LA Amos CI Seldin MF Kastner DL Klareskog L Gregersen PK TRAF1-C5 as a risk locus for rheumatoid arthritis - a genomewide study N Engl J Med 2007, 357:1199-1209. 2636867 17804836 10.1056/NEJMoa073491
4. Thomson W Barton A Ke X Eyre S Hinks A Bowes J Donn R Symmons D Hider S Bruce IN Wellcome Trust Case Control Consortium Wilson AG Marinou I Morgan A Emery P YEAR Consortium Carter A Steer S Hocking L Reid DM Wordsworth P Harrison P Strachan D Worthington J Rheumatoid arthritis association at 6q23 Nat Genet 2007, 39:1431-1433. 10.1038/ng.2007.32 17982455
5. Barton A Thomson W Ke X Eyre S Hinks A Bowes J Gibbons L Plant D Wellcome Trust Case Control Consortium Wilson AG Marinou I Morgan A Emery P YEAR consortium Steer S Hocking L Reid DM Wordsworth P Harrison P Worthington J Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility Hum Mol Genet 2008, 17:2274-2279. 2465799 18434327 10.1093/hmg/ddn128
6. Graham RR Cotsapas C Davies L Hackett R Lessard CJ Leon JM Burtt NP Guiducci C Parkin M Gates C Plenge RM Behrens TW Wither JE Rioux JD Fortin PR Graham DC Wong AK Vyse TJ Daly MJ Altshuler D Moser KL Gaffney PM Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus Nat Genet 2008, 40:1059-1061. 10.1038/ng.200 19165918
7. Musone SL Taylor KE Lu TT Nititham J Ferreira RC Ortmann W Shifrin N Petri MA Kamboh MI Manzi S Seldin MF Gregersen PK Behrens TW Ma A Kwok PY Criswell LA Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus Nat Genet 2008, 40:1062-1064. 10.1038/ng.202 19165919
8. Lee EG Boone DL Chai S Libby SL Chien M Lodolce JP Ma A Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice Science 2000, 289:2350-2354. 10.1126/science.289.5488.2350 11009421
9. Heyninck K Beyaert R A20 inhibits NF-kappaB activation by dual ubiquitin-editing functions Trends Biochem Sci 2005, 30:1-4. 10.1016/ j.tibs.2004.11.001 15653317
10. Beyaert R Heyninck K Van Huffel S A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis Biochem Pharmacol 2000, 60:1143-1151. 10.1016/ S0006-2952(00)00404-4 11007952
11. Dieguez-Gonzalez R Akar S Calaza M Perez-Pampin E Costas J Torres M Vicario JL Velloso ML Navarro F Narvaez J Joven B Herrero-Beaumont G Gonzalez-Alvaro I Fernandez-Gutierrez B de la Serna AR Carreño L Lopez-Longo J Caliz R Collado-Escobar MD Blanco FJ Fernandez-Lopez C Balsa A Pascual-Salcedo D Gomez-Reino JJ Gonzalez A Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis Ann Rheum Dis 2009, 68:579-583. 10.1136/ ard.2007.087304 18434448
12. Arnett FC Edworthy SM Bloch DA Mcshane DJ Fries JF Cooper NS Healey LA Kaplan SR Liang MH Luthra HS Medsger TA Jr Mitchell DM Neustadt DH Pinals RS Schaller JG Sharp JT Wilder RL Hunder G The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis Arthritis Rheum 1988, 31:315-324. 10.1002/ art.1780310302 3358796
13. International HapMap Consortium Frazer KA Ballinger DG Cox DR Hinds DA Stuve LL Gibbs RA Belmont JW Boudreau A Hardenbol P Leal SM Pasternak S Wheeler DA Willis TD Yu F Yang H Zeng C Gao Y Hu H Hu W Li C Lin W Liu S Pan H Tang X Wang J Wang W Yu J Zhang B Zhang Q et al A second generation human haplotype map of over 3.1 million SNPs Nature 2007, 449:851-861. 10.1038/nature06258 17943122
14. Barrett JC Fry B Maller J Daly MJ Haploview: Analysis and visualization of LD and haplotype maps Bioinformatics 2005, 21:263-265. 10.1093/ bioinformatics/bth457 15297300
15. Stephens M Smith NJ Donnelly P A new statistical method for haplotype reconstruction from population data Am J Hum Genet 2001, 68:978-989. 1275651 11254454 10.1086/319501
16. Dupont WD Plummer WD Jr Power and sample size calculations. A review and computer program Control Clin Trials 1990, 11:116-128. 10.1016/ 0197-2456(90)90005-M 2161310
17. Thomson W Barton A Eyre S Ke X Hinks A UKRAG Consortium Wilson G Worthington J Characterisation of the 6q23 rheumatoid arthritis susceptibility locus Arthritis Rheum 2008, 58:S214-S215.
18. Boonyasrisawat W Eberle D Bacci S Zhang YY Nolan D Gervino EV Johnstone MT Trischitta V Shoelson SE Doria A Tag polymorphisms at the A20 (TNFAIP3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes Diabetes 2007, 56:499-505. 10.2337/db06-0946 17259397
19. Huizinga TW Amos CI Helm-van Mil van der AH Chen W van Gaalen FA Jawaheer D Schreuder GM Wener M Breedveld FC Ahmad N Lum RF de Vries RR Gregersen PK Toes RE Criswell LA Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins Arthritis Rheum 2005, 52:3433-3438. 10.1002/art.21385 16255021
20. Kallberg H Padyukov L Plenge RM Ronnelid J Gregersen PK Helm-van Mil van der AH Toes RE Huizinga TW Klareskog L Alfredsson L Epidemiological Investigation of Rheumatoid Arthritis Study Group Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis Am J Hum Genet 2007, 80:867-875. 1852748 17436241 10.1086/516736
21. Dieguez-Gonzalez R Calaza M Perez-Pampin E de la Serna AR Fernandez-Gutierrez B Castañeda S Largo R Joven B Narvaez J Navarro F Marenco JL Vicario JL Blanco FJ Fernandez-Lopez JC Caliz R Collado-Escobar MD Carreño L Lopez-Longo J Cañete JD Gomez-Reino JJ Gonzalez A Association of interferon regulatory factor 5 haplotypes, similar to that found in systemic lupus erythematosus, in a large subgroup of patients with rheumatoid arthritis Arthritis Rheum 2008, 58:1264-1274. 10.1002/art.23426 18438842
22. Ioannidis JP Why most discovered true associations are inflated Epidemiology 2008, 19:640-648. 10.1097/EDE.0b013e31818131e7 18633328