The use of 99mTc-recombinant human annexin v imaging for differential diagnosis of aseptic loosening and low-grade infection in hip and knee prostheses

Journal of Nuclear Medicine

Volumn 50, Issue 4, 2009, Pages 534-537

  Lorberboym, Mordechai ^a,c   Feldbrin, Zeev ^a   Hendel, David ^a   Blankenberg, Francis G ^b   Schachter, Pinhas ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WOLFSON MEDICAL CENTER   (Israel)

Author keywords

Annexin v; Apoptosis; Hip; Infection; Knee; Loosening; Prosthesis

Indexed keywords

HYDRAZINONICOTINAMIDE RECOMBINANT HUMAN ANNEXIN V CONJUGATE PERTECHNETATE TC 99M; MEDRONATE TECHNETIUM TC 99M; TRACER; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; LIPOCORTIN 5; RADIOPHARMACEUTICAL AGENT; RECOMBINANT PROTEIN; TECHNETIUM COMPLEX; TECHNETIUM TC 99M ANNEXIN V;

AGED; ARTICLE; BACTERIUM CULTURE; BONE SCINTISCANNING; CLINICAL ARTICLE; CLINICAL TRIAL; DIAGNOSTIC IMAGING; DIFFERENTIAL DIAGNOSIS; DRUG DISTRIBUTION; DRUG UPTAKE; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; FEMALE; FOLLOW UP; HIP PROSTHESIS; HUMAN; ISOTOPE LABELING; KNEE PROSTHESIS; LABORATORY TEST; MALE; PATHOLOGY; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROSTHESIS INFECTION; PROSTHESIS LOOSENING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TOTAL HIP PROSTHESIS; TOTAL KNEE REPLACEMENT; BACTERIAL INFECTION; EQUIPMENT; HIP; INFECTION; JOINT INSTABILITY; KNEE; METABOLISM; METHODOLOGY; PREDICTION AND FORECASTING; PROSTHESIS FAILURE; SCINTISCANNING;

AGED; AGED, 80 AND OVER; ANNEXIN A5; BACTERIAL INFECTIONS; DIAGNOSIS, DIFFERENTIAL; EQUIPMENT FAILURE ANALYSIS; FEMALE; HIP JOINT; HIP PROSTHESIS; HUMANS; JOINT INSTABILITY; KNEE JOINT; KNEE PROSTHESIS; MALE; ORGANOTECHNETIUM COMPOUNDS; PREDICTIVE VALUE OF TESTS; PROSTHESIS FAILURE; PROSTHESIS-RELATED INFECTIONS; RADIOPHARMACEUTICALS; RECOMBINANT PROTEINS;

EID: 63849296919     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.108.059345     Document Type: Article

References (20)

1. Puskas BL, Menke NE, Huie P, et al. Expression of nitric oxide, peroxynitrite, and apoptosis in loose total hip replacements. J Biomed Mater Res A. 2003;66:541-549.
2. Fihman V, Hannouche D, Bousson V, et al. Improved diagnosis specificity in bone and joint infections using molecular techniques. J Infect. 2007;55:510-517.
3. Nagoya S, Kaya M, Sasaki M, Tateda K, Yamashita T. Diagnosis of peri-prosthetic infection at the hip using triple-phase bone scintigraphy. J Bone Joint Surg. 2008;90-B:140-144.
4. Törmänen J, Tervonen O, Koivula A, Junila J, Suramo I. Image technique optimization in MR imaging of a titanium alloy joint prosthesis. J Magn Reson Imaging. 1996;6:805-811.
5. Van den Brande JM, Koehler TC, Zelinkova Z, et al. Prediction of antitumour necrosis factor clinical efficacy by real-time visualisation of apoptosis in patients with Crohn's disease. Gut. 2007;56:509-517.
6. Kietselaer BL, Narula J, Hofstra L. The annexin code: revealing endocarditis. Eur Heart J. 2007;28:948.
7. Funakoshi T, Hendrickson LE, McMullen BA, Fujikawa K. Primary structure of human placental anticoagulant protein. Biochemistry. 1987;26:8087-8092.
8. 99mTc-labeled Hynic-derivatized annexin V for human use. Nucl Med Biol. 2003;30:771-778.
9. Blankenberg FG. In vivo detection of apoptosis. J Nucl Med. 2008;49(suppl 2):81S-95S.
10. Landgraeber S, Toetsch M, Wedemeyer C, et al. Over-expression of p53/BAK in aseptic loosening after total hip replacement. Biomaterials. 2006;27:3010-3020.
11. al-Saffar N, Revell PA. Pathology of the bone-implant interfaces. J Long Term EffMed Implants. 1999;9:319-347.
12. Fink SL, Cookson BT. Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect Immun. 2005;73:1907-1916.
13. Maderazo EG, Judson S, Pasternak H. Late infections of total joint prostheses: a review and recommendation for prevention. Clin Orthop. 1988;229:131-142.
14. Segura AB, Munoz A, Brulles YR, et al. What is the role of bone scintigraphy in the diagnosis of infected joint prostheses? Nucl Med Commun. 2004;25:527-532.
15. Oswald SG, Van Nostrand D, Savory CG, Callaghan JJ. Three phase bone scintigraphy scan and indium white blood cell scintigraphy following porous coated hip arthroplasty: a prospective study of the prosthetic tip. J Nucl Med. 1989;30:1321-1331.
16. Palestro CJ, Love C. Radionuclide imaging of musculoskeletal infection: conventional agents. Semin Musculoskelet Radiol. 2007;11:335-352.
17. Itasaka T, Kawai A, Sato T, Mitani S, Inoue H. Diagnosis of infection after total hip arthroplasty. J Orthop Sci. 2001;6:320-326.
18. Gomez-Luzuriaga MA, Galan V, Villar JM. Scintigraphy with Tc, Ga and In in painful total hip prosthesis. Int Orthop. 1988;12:163-167.
19. Kwee TC, Kwee RM, Alavi A. FDG-PET for diagnosing prosthetic joint infection: systematic review and metaanalysis. Eur J Nucl Med Mol Imaging. 2008;35:2122-2132.
20. Love C, Tomas MB, Marwin SE, Pugliese PV, Palestro CJ. Role of nuclear medicine in diagnosis of the infected joint replacement. Radiographics. 2001;21:1229-1238.