Will non-invasive markers replace liver biopsy for diagnosing and staging fibrosis in non-alcoholic steatohepatitis?

Journal of Gastroenterology and Hepatology (Australia)

Volumn 24, Issue 4, 2009, Pages 501-503

  Hashimoto, Etsuko ^a,c   Farrell, Geoffrey C ^b  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b The Australian National University   (Australia)

^c NONE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CYTOKERATIN 18; HYALURONIC ACID; INTERLEUKIN 6; LEPTIN; THIOREDOXIN; TUMOR NECROSIS FACTOR ALPHA;

DISEASE CLASSIFICATION; DISEASE SEVERITY; EDITORIAL; HUMAN; LIVER BIOPSY; LIVER FIBROSIS; NONALCOHOLIC FATTY LIVER; PRIORITY JOURNAL; SCORING SYSTEM;

EID: 63849278008     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2009.05806.x     Document Type: Editorial

References (17)

1. Amarapurkar DN, Hashimoto E, Lesmana LA et al. How common is non-alcoholic fatty liver disease in the Asia-Pacific region and are there local differences? J. Gastroenterol. Hepatol. 2007 22 : 788 93.
2. Ludwig J, Viggiano TR, McGill DB et al. Nonalcoholic steatohepatitis. Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin. Proc. 1980 55 : 434 8.
3. Matteoni CA, Younossi ZM, Gramlich T et al. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999 116 : 1413 19.
4. Brunt EM, Janney CG, DiBisceglie AM et al. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am. J. Gastroenterol. 1999 94 : 2467 74.
5. Kleiner DE, Brunt EM, Van Natta M et al. Nonalcoholic Steatohepatitis Clinical Research Network. Related Articles: design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005 41 : 1313 21.
6. Farrell GC, Chitturi S, Lau GKK et al. Guidelines for the assessment and management of non-alcoholic fatty liver disease in the Asia-Pacific region: executive summary. J. Gastroenterol. Hepatol. 2007 22 : 775 7.
7. Tokushige K, Takakura M, Hashimoto E et al. Influence of TNF gene polymorphisms in Japanese patients with NASH and simple steatosis. J. Hepatol. 2007 46 : 1104 10.
8. Wieckowska A, Zein N, Yerian LM et al. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 2006 44 : 27 33.
9. Wieckowska A, Lopez AR, Zein NN et al. Noninvasive assessment of hepatocyte apoptosis in nonalcoholic fatty liver disease; a multi-center validation study. Gastroenterology 2007 132 : A729.
10. Diab D, Yerian L, Schauer P et al. Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients. Clin. Gastroenterol. Hepatol. 2008 6 : 1249 54.
11. Malik R, Chang M, Bhaskar K et al. The clinical utility of biomarkers and the nonalcoholic steatohepatitis CRN liver biopsy scoring system in patients with nonalcoholic fatty liver disease. J. Gastroenterol. Hepatol. 2009 24 : 564 8.
12. Campos GM, Bambha K, Vittinghoff E et al. A clinical scoring system for predicting nonalcoholic steatohepatitis in morbidly obese patients. Hepatology 2008 47 : 1916 23.
13. Younossi ZM, Jarrar M, Nugent C et al. A novel diagnostic biomarker panel for obesity-related nonalcoholic steatohepatitis (NASH). Obes. Surg. 2008 18 : 1430 7.
14. Kaneda H, Hashimoto E, Yatsuji S et al. Hyaluronic acid levels can predict severe fibrosis and platelet counts can predict cirrhosis in patients with nonalcoholic fatty liver disease. J. Gastroenterol. Hepatol. 2006 21 : 1459 65.
15. Angulo P, Hui JM, Marchesini G et al. The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology 2007 45 : 846 54.
16. Harrison S, Oliver D, Arnold H et al. Development and validation of a simple NAFLD clinical scoring system for identifying patients without advanced disease. Gut 2008 57 : 1441 7.
17. Cales P, Laine F, Boursier J et al. Comparison of blood tests for liver fibrosis specific or not to NAFLD. J. Hepatol. 2009 50 : 165 73.