Intracellular potassium stabilizes human ether-à-go-go-related gene channels for export from endoplasmic reticulum

Molecular Pharmacology

Volumn 75, Issue 4, 2009, Pages 927-937

  Wang, Lu ^a   Dennis, Adrienne T ^a   Trieu, Phan ^b   Charron, Francois ^b   Ethier, Natalie ^b   Hebert, Terence E ^b   Wan, Xiaoping ^a   Ficker, Eckhard ^a,c  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b MCGILL UNIVERSITY   (Canada)

^c METROHEALTH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASTEMIZOLE; CARDIAC GLYCOSIDE; GRAMICIDIN; MUTANT PROTEIN; POTASSIUM CHANNEL HERG; POTASSIUM ION; SODIUM;

ARTICLE; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; LOW TEMPERATURE; POTASSIUM CELL LEVEL; PRIORITY JOURNAL; PROTEIN TRANSPORT;

CARDIAC GLYCOSIDES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; INTRACELLULAR FLUID; POTASSIUM; PROTEIN TRANSPORT;

EID: 63849242843     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.053793     Document Type: Article

References (46)

1. + channel inactivation. Cell Biochem Biophys 41:25-40.
2. Cordes JS, Sun Z, Lloyd DB, Bradley JA, Opsahl AC, Tengowski MW, Chen X, and Zhou J (2005) Pentamidine reduces hERG expression to prolong the QT interval. Br J Pharmacol 145:15-23.
3. Cordero-Morales JF, Jogini V, Lewis A, Vasquez V, Cortes DM, Roux B, and Perozo E (2007) Molecular driving forces determining potassium channel slow inactivation. Nat Struct Mol Biol 14:1062-1069.
4. Cera E (2006) A structural perspective on enzymes activated by monovalent cations. J Biol Chem 281:1305-1308.
5. Dmitrieva RI and Doris PA (2003) Ouabain is a promoter of growth and activator of ERK1/2 in ouabain-resistant rat renal epithelial cells. J Biol Chem 278:28160-28166.
6. Ficker E, Obejero-Paz CA, Zhao S, and Brown AM (2002) The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (hERG) mutations. J Biol Chem 277:4989-4998.
7. Ficker E, Dennis AT, Wang L, and Brown AM (2003) Role ofthe cytosolic chaperones Hsp70andHsp90inmaturationofthecardiacpotassiumchannelHERG. CircRes 92:e87-100.
8. Ficker E, Kuryshev YA, Dennis AT, Obejero-Paz C, Wang L, Hawryluk P, Wible BA, and Brown AM (2004) Mechanisms of arsenic-induced prolongation of cardiac repolarization. Mol Pharmacol 66:33-44.
9. + permeation and block of hERG potassium channels. J Gen Physiol 128:55-71.
10. +ions: a remarkable stable non-conducting state produced by membrane depolarizations. J Physiol 499:3-15.
11. Greger IH, Khatri L, Kong X, and Ziff EB (2003) AMPA receptor tetramerization is mediated by Q/R editing. Neuron 40:763-774.
12. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440-3450.
13. Kr and its trafficking disruption induced by probucol in cultured neonatal rat cardiomyocytes. J Pharmacol Exp Ther 321:911-920.
14. + in individual fibroblasts and lymphocytes. J Biol Chem 264:19458-19467.
15. Kasner SE and Ganz MB (1992) Regulation of intracellular potassium in mesangial cells: a fluorescence analysis using the dye, PBFI. Am J Physiol 262:F462-F467.
16. +. Mol Pharmacol 56:619-632. Kometiani P, Li J, Gnudi L, Kahn BB, Askari A, and Xie Z
17. +-ATPase to growth-related genes in cardiac myocytes. J Biol Chem 273:15249-15256.
18. +-ATPase in human breast cancer cells. Mol Pharmacol 67:929-936.
19. Krishnan MN, Bingham JP, Lee SH, Trombley P, and Moczydlowski E (2005) Functional role and affinity of inorganic cations in stabilizing the tetrameric structure of the KcsA K+ channel. J Gen Physiol 126:271-283.
20. Kuryshev YA, Ficker E, Wang L, Hawryluk P, Dennis AT, Wible BA, Brown AM, Kang J, Chen XL, Sawamura K, et al. (2005) Pentamidine-induced long QT syndrome and block of hERG trafficking. J Pharmacol Exp Ther 312:316-323.
21. Lin H, Juang JL, and Wang PS (2004) Involvement of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis. J Biol Chem 279:29302-29307.
22. 2+ concentrations. J Biol Chem 275:27838-27844.
23. +. Biophys J 80:2704-2714.
24. + channel. PLoS Biol 5:e121.
25. Minta A and Tsien RY (1989) Fluorescent indicators for cytosolic sodium. J Biol Chem 264:19449-19457.
26. Mullins FM, Stepanovic SZ, Desai RR, George AL Jr, and Balser JR (2002) Extracellular sodium interacts with the HERG channel at an outer pore site. J Gen Physiol 120:517-537.
27. Nilsson C, Kågedal K, Johansson U, and Ollinger K (2003) Analysis of cytosolic and lysosomal pH in apoptotic cells by flow cytometry. Methods Cell Sci 25:185-194.
28. O'Brien MC and McKay DB (1995) How potassium affects the activity of the molecular chaperone Hsp70. J Biol Chem 270:2247-2250.
29. Palasis M, Kuntzweiler TA, Argüello JM, and Lingrel JB (1996) Ouabain interactions with the H5-H6 hairpin of the Na,K-ATPase reveal a possible inhibition mechanism via the cation binding domain. JBiol Chem 271:14176-14182.
30. + exchange in gastric glands as measured with a cytoplasmic-trapped, fluorescent pH indicator. Proc Natl Acad Sci U S A 81:7436-7440.
31. Pierre SV and Xie Z (2006) The Na,K-ATPase receptor complex: its organization and membership. Cell Biochem Biophys 46:303-316.
32. Rajamani S, Eckhardt LL, Valdivia CR, Klemens CA, Gillman BM, Anderson CL, Holzem KM, Delisle BP, Anson BD, Makielski JC, et al. (2006) Drug-induced long
33. + channel block and disruption of protein trafficking by fluoxetine and norfluoxetine. Br J Pharmacol 149:481-489.
34. +-channel dysfunction in an inherited arrhythmia. Proc Natl Acad Sci USA 93:2208-2212.
35. Sanguinetti MC and Mitcheson JS (2005) Predicting drug-hERG channel interactions that cause acquired long QT syndrome. Trends Pharmacol Sci 26:119-124.
36. Sanguinetti MC and Tristani-Firouzi M. (2006) hERG potassium channels and cardiac arrhythmia. Nature 440:463-469.
37. Takemasa H, Nagatomo T, Abe H, Kawakami K, Igarashi T, Tsurugi T, Kabashima N, Tamura M, Okazaki M, Delisle BP, et al. (2007) Coexistence of hERG current
38. block and disruption of protein trafficking in ketoconazole-induced long QT syndrome. Br J Pharmacol 153:439-447.
39. van der Heyden MA, Smits ME, and Vos MA (2007) Drugs and trafficking of ion channels: a new pro-arrhythmic threat on the horizon? Br J Pharmacol 153:406-409.
40. Wang L, Wible BA, Wan X, and Ficker E (2007) Cardiac glycosides as novel inhibitors of human ether-a-gogo-related gene channel trafficking. J Pharmacol Exp Ther 320:525-534.
41. Wible BA, Hawryluk P, Ficker E, Kuryshev YA, Kirsch G, and Brown AM (2005) HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk. J Pharmacol Toxicol Methods 52:136-145.
42. +-ATPase to hypertrophy and its marker genes in cardiac myocytes. J Biol Chem 274:19323-19328.
43. Zhou Y, Morais-Cabral JH, Kaufman A, and MacKinnon R. (2001) Chemistry of ion coordination and hydration revealed by a K+ channel Fab complex at 2.0 Å resolution. Nature 414:43-48.
44. + selectivity filter: charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates. J Mol Biol 333:965-975.
45. Zhou Y and MacKinnon R (2004) Ion binding affinity in the cavity of the KcsA potassium channel. Biochemistry 43:4978-4982.
46. + channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation. J Physiol 509:129-137.