Deletion of the gene encoding the glycolytic enzyme triosephosphate isomerase (tpi) alters morphology of Salmonella enterica serovar Typhimurium and decreases fitness in mice

FEMS Microbiology Letters

Volumn 294, Issue 1, 2009, Pages 45-51

  Paterson, Gavin K ^a   Cone, Danielle B ^a   Northen, Helen ^a   Peters, Sarah E ^a   Maskell, Duncan J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Salmonella; Triosephosphate isomerase; Virulence

Indexed keywords

GLYCOLYTIC ENZYME; LIVE VACCINE; TRIOSEPHOSPHATE ISOMERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COUNT; BACTERIAL GENE; BACTERIAL INFECTION; CELL STRUCTURE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; FITNESS; GENE DELETION; IN VIVO STUDY; LIVER; MOUSE; MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SALMONELLA ENTERICA; SALMONELLA TYPHIMURIUM; SPLEEN; TPIA GENE; TYPHOID FEVER; WILD TYPE;

ANIMALS; BACTERIAL PROTEINS; COLONY COUNT, MICROBIAL; GENE DELETION; GENETIC COMPLEMENTATION TEST; LIVER; MICE; PARATYPHOID FEVER; SALMONELLA TYPHIMURIUM; SPLEEN; TRIOSE-PHOSPHATE ISOMERASE; VIRULENCE FACTORS;

BACTERIA (MICROORGANISMS); MUS; SALMONELLA; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM;

EID: 63849220099     PISSN: 03781097     EISSN: 15746968     Source Type: Journal    
DOI: 10.1111/j.1574-6968.2009.01553.x     Document Type: Article

References (19)

1. Anderson A Cooper RA (1969) Gluconeogenesis in Escherichia coli the role of triose phosphate isomerase. FEBS Lett 4 : 19 20.
2. Booth IR, Ferguson GP, Miller S, Li C, Gunasekera B Kinghorn S (2003) Bacterial production of methylglyoxal: a survival strategy or death by misadventure? Biochem Soc Trans 31 : 1406 1408.
3. Brown SA, Palmer KL Whiteley M (2008) Revisiting the host as a growth medium. Nat Rev Micro 6 : 657 666.
4. Bullas LR Ryu JI (1983) Salmonella typhimurium LT2 strains which are r- m+ for all three chromosomally located systems of DNA restriction and modification. J Bacteriol 156 : 471 474.
5. Cooper RA (1984) Metabolism of methylglyoxal in microorganisms. Annu Rev Microbiol 38 : 49 68.
6. Cooper RA Anderson A (1970) The formation and catabolism of methylglyoxal during glycolysis in Escherichia coli. FEBS Lett 11 : 273 276.
7. Eriksson S, Lucchini S, Thompson A, Rhen M Hinton JCD (2003) Unravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella enterica. 47 : 103 118.
8. Ferguson GP, Chacko AD, Lee CH Booth IR (1996) The activity of the high-affinity K+ uptake system Kdp sensitizes cells of Escherichia coli to methylglyoxal. J Bacteriol 178 : 3957 3961.
9. Ferguson GP, Totemeyer S, MacLean MJ Booth IR (1998) Methylglyoxal production in bacteria: suicide or survival? Arch Microbiol 170 : 209 219.
10. Hoiseth SK Stocker BA (1981) Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines. Nature 291 : 238 239.
11. Irani MH Maitra PK (1977) Properties of Escherichia coli mutants deficient in enzymes of glycolysis. J Bacteriol 132 : 398 410.
12. Mercado-Lubo R, Gauger EJ, Leatham MP, Conway T Cohen PS (2008) A Salmonella enterica serovar Typhimurium succinate dehydrogenase/fumarate reductase double mutant is avirulent and immunogenic in BALB/c mice. Infect Immun 76 : 1128 1134.
13. Mo E, Peters SE, Willers C, Maskell DJ Charles IG (2006) Single, double and triple mutants of Salmonella enterica serovar Typhimurium degP (htrA), degQ (hhoA) and degS (hhoB) have diverse phenotypes on exposure to elevated temperature and their growth in vivo is attenuated to different extents. Microb Pathogenesis 41 : 174 182.
14. Munoz-Elias EJ McKinney JD (2006) Carbon metabolism of intracellular bacteria. Cell Microbiol 8 : 10 22.
15. Poysti NJ Oresnik IJ (2007) Characterization of Sinorhizobium meliloti triose phosphate isomerase genes. J Bacteriol 189 : 3445 3451.
16. Schmieger H (1972) Phage P22-mutants with increased or decreased transduction abilities. Mol Gen Genet 119 : 75 88.
17. Smith H (2000) Questions about the behaviour of bacterial pathogens in vivo. Philos T Roy Soc B 355 : 551 564.
18. Totemeyer S, Booth NA, Nichols WW, Dunbar B Booth IR (1998) From famine to feast: the role of methylglyoxal production in Escherichia coli. Mol Microbiol 27 : 553 562.
19. Zheng P, Sun JB, van den Heuvel J Zeng AP (2006) Discovery and investigation of a new, second triose phosphate isomerase in Klebsiella pneumoniae. J Biotechnol 125 : 462 473.