메뉴 건너뛰기




Volumn 32, Issue 3, 2009, Pages 129-138

Molecular targeted therapies for solid tumors: Management of side effects

Author keywords

Adverse event; Kinase inhibitors; Management; Molecular targeted therapy

Indexed keywords

AFINITOR; BEVACIZUMAB; CAPECITABINE; CEDIRANIB; CELECOXIB; CETUXIMAB; CORTICOSTEROID; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; EVEROLIMUS; FLUOROURACIL; FOLINIC ACID; GEFITINIB; IRINOTECAN; LAPATINIB; MAMMALIAN TARGET OF RAPAMYCIN; METRONIDAZOLE; MONOCLONAL ANTIBODY; PANITUMUMAB; PROTEIN SERINE THREONINE KINASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; PYRIDOXINE; SORAFENIB; SUNITINIB; TEMSIROLIMUS; TETRACYCLINE; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN; VASCULOTROPIN INHIBITOR;

EID: 63849189675     PISSN: 0378584X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000194949     Document Type: Article
Times cited : (25)

References (55)
  • 2
    • 34648813908 scopus 로고    scopus 로고
    • Managing side effects of angiogenesis inhibitors in renal cell carcinoma
    • Grunwald V, Heinzer H, Fiedler W: Managing side effects of angiogenesis inhibitors in renal cell carcinoma. Onkologie 2007;30:519-524.
    • (2007) Onkologie , vol.30 , pp. 519-524
    • Grunwald, V.1    Heinzer, H.2    Fiedler, W.3
  • 3
    • 38049025794 scopus 로고    scopus 로고
    • Review: Side effects of approved molecular targeted therapies in solid cancers
    • Widakowich C, de Castro G, Jr, Azambuja E, Dinh P, Awada A: Review: Side effects of approved molecular targeted therapies in solid cancers. Oncologist 2007;12:1443-1455.
    • (2007) Oncologist , vol.12 , pp. 1443-1455
    • Widakowich, C.1    de Castro Jr, G.2    Azambuja, E.3    Dinh, P.4    Awada, A.5
  • 4
    • 40349106029 scopus 로고    scopus 로고
    • The potential role of mTOR inhibitors in non-small cell lung cancer
    • Gridelli C, Maione P, Rossi A: The potential role of mTOR inhibitors in non-small cell lung cancer. Oncologist 2008;13:139-147.
    • (2008) Oncologist , vol.13 , pp. 139-147
    • Gridelli, C.1    Maione, P.2    Rossi, A.3
  • 5
    • 48749128305 scopus 로고    scopus 로고
    • Bellmunt J, Szczylik C, Feingold J, Strahs A, Berkenbilt A: Temsirolimus safety profile and management of toxic effects in patients with advanced renal cell carcinoma and poor prognostic features. Ann Oncol 2008;19(suppl 2):ii47-48.
    • Bellmunt J, Szczylik C, Feingold J, Strahs A, Berkenbilt A: Temsirolimus safety profile and management of toxic effects in patients with advanced renal cell carcinoma and poor prognostic features. Ann Oncol 2008;19(suppl 2):ii47-48.
  • 7
    • 63849222670 scopus 로고    scopus 로고
    • Van Cutsem E, Michael M, Berry S, Dibartolomeo M, Rivera F, Kretzschmar A, Mazier M, Lutiger B, Cunningham D: Preliminary safety and efficacy of bevacizumab with first-line FOLFOX, XELOX, FOLFIRI, and capecitabine for mCRC: First BEA-Trial. ASCO GI 2007;abstr 346.
    • Van Cutsem E, Michael M, Berry S, Dibartolomeo M, Rivera F, Kretzschmar A, Mazier M, Lutiger B, Cunningham D: Preliminary safety and efficacy of bevacizumab with first-line FOLFOX, XELOX, FOLFIRI, and capecitabine for mCRC: First BEA-Trial. ASCO GI 2007;abstr 346.
  • 13
    • 34447130180 scopus 로고    scopus 로고
    • FDA drug approval summary: Bevacizumab (avastin) plus carboplatin and paclitaxel as first-line treatment of advanced/metastatic recurrent nonsquamous non-small cell lung cancer
    • Cohen MH, Gootenberg J, Keegan P, Pazdur R: FDA drug approval summary: Bevacizumab (avastin) plus carboplatin and paclitaxel as first-line treatment of advanced/metastatic recurrent nonsquamous non-small cell lung cancer. Oncologist 2007;12:713-718.
    • (2007) Oncologist , vol.12 , pp. 713-718
    • Cohen, M.H.1    Gootenberg, J.2    Keegan, P.3    Pazdur, R.4
  • 14
    • 34249294557 scopus 로고    scopus 로고
    • Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition
    • Verheul HM, Pinedo HM: Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition. Nat Rev Cancer 2007;7:475-485.
    • (2007) Nat Rev Cancer , vol.7 , pp. 475-485
    • Verheul, H.M.1    Pinedo, H.M.2
  • 15
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Kabbinavar F, Hurwitz HI, Fehrenbacher L, Meropol NJ, Novotny WF, Lieberman G, Griffing S, Bergsland E: Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 2003;21:60-65.
    • (2003) J Clin Oncol , vol.21 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3    Meropol, N.J.4    Novotny, W.F.5    Lieberman, G.6    Griffing, S.7    Bergsland, E.8
  • 17
    • 33749018219 scopus 로고    scopus 로고
    • Mechanisms of cutaneous toxicities to EGFR inhibitors
    • Lacouture ME: Mechanisms of cutaneous toxicities to EGFR inhibitors. Nat Rev Cancer 2006;6:803-812.
    • (2006) Nat Rev Cancer , vol.6 , pp. 803-812
    • Lacouture, M.E.1
  • 18
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • Saltz LB, Meropol NJ, Loehrer PJ, Sr, Needle MN, Kopit J, Mayer RJ: Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004;22:1201-1208.
    • (2004) J Clin Oncol , vol.22 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer Sr, P.J.3    Needle, M.N.4    Kopit, J.5    Mayer, R.J.6
  • 19
    • 1842772526 scopus 로고    scopus 로고
    • Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck
    • Soulieres D, Senzer NN, Vokes EE, Hidalgo M, Agarwala SS, Siu LL: Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J Clin Oncol 2004;22:77-85.
    • (2004) J Clin Oncol , vol.22 , pp. 77-85
    • Soulieres, D.1    Senzer, N.N.2    Vokes, E.E.3    Hidalgo, M.4    Agarwala, S.S.5    Siu, L.L.6
  • 20
    • 24644513947 scopus 로고    scopus 로고
    • Cutaneous adverse effects with HER1/EGFR-targeted agents: Is there a silver lining?
    • Perez-Soler R, Saltz L: Cutaneous adverse effects with HER1/EGFR-targeted agents: Is there a silver lining? J Clin Oncol 2005;23:5235-5246.
    • (2005) J Clin Oncol , vol.23 , pp. 5235-5246
    • Perez-Soler, R.1    Saltz, L.2
  • 22
    • 3242799070 scopus 로고    scopus 로고
    • New advances on the functions of epidermal growth factor receptor and ceramides in skin cell differentiation, disorders and cancers
    • Mimeault M, Bonenfant D, Batra SK: New advances on the functions of epidermal growth factor receptor and ceramides in skin cell differentiation, disorders and cancers. Skin Pharmacol Physiol 2004;17:153-166.
    • (2004) Skin Pharmacol Physiol , vol.17 , pp. 153-166
    • Mimeault, M.1    Bonenfant, D.2    Batra, S.K.3
  • 24
    • 0142241307 scopus 로고    scopus 로고
    • Hair depigmentation is a biological readout for pharmacological inhibition of kit in mice and humans
    • Moss KG, Toner GC, Cherrington JM, Mendel DB, Laird AD: Hair depigmentation is a biological readout for pharmacological inhibition of kit in mice and humans. J Pharmacol Exp Ther 2003;307:476-480.
    • (2003) J Pharmacol Exp Ther , vol.307 , pp. 476-480
    • Moss, K.G.1    Toner, G.C.2    Cherrington, J.M.3    Mendel, D.B.4    Laird, A.D.5
  • 26
    • 0344034808 scopus 로고    scopus 로고
    • Pyridoxine treatment and prevention of hand-and-foot syndrome in patients receiving capecitabine
    • Mortimer JE, Lauman MK, Tan B: Pyridoxine treatment and prevention of hand-and-foot syndrome in patients receiving capecitabine. J Oncol Pharm Pract 2003;9:161-166.
    • (2003) J Oncol Pharm Pract , vol.9 , pp. 161-166
    • Mortimer, J.E.1    Lauman, M.K.2    Tan, B.3
  • 27
    • 0036985988 scopus 로고    scopus 로고
    • Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity
    • Lin E, Morris JS: Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity. Oncology 2002;16(suppl 14):31-37.
    • (2002) Oncology , vol.16 , Issue.SUPPL. 14 , pp. 31-37
    • Lin, E.1    Morris, J.S.2
  • 28
    • 33751234523 scopus 로고    scopus 로고
    • Managing the side effects of sorafenib and sunitinib
    • Wood LS: Managing the side effects of sorafenib and sunitinib. Commun Oncol 2006;3:558-562.
    • (2006) Commun Oncol , vol.3 , pp. 558-562
    • Wood, L.S.1
  • 30
    • 63849306162 scopus 로고    scopus 로고
    • www.mascc.org/media/Resource-centers/Guidelines-mucositis.pdf.
  • 31
    • 63849122300 scopus 로고    scopus 로고
    • www.onkosupport.de/asors/content.
  • 33
    • 34548222618 scopus 로고    scopus 로고
    • Lapatinib-associated toxicity and practical management recommendations
    • Moy B, Goss PE: Lapatinib-associated toxicity and practical management recommendations. Oncologist 2007;12:756-765.
    • (2007) Oncologist , vol.12 , pp. 756-765
    • Moy, B.1    Goss, P.E.2
  • 34
    • 13344294983 scopus 로고    scopus 로고
    • Management of chemotherapy-induced nausea, vomiting, oral mucositis, and diarrhoea
    • Sharma R, Tobin P, Clarke SJ: Management of chemotherapy-induced nausea, vomiting, oral mucositis, and diarrhoea. Lancet Oncol 2005;6:93-102.
    • (2005) Lancet Oncol , vol.6 , pp. 93-102
    • Sharma, R.1    Tobin, P.2    Clarke, S.J.3
  • 35
    • 33846638744 scopus 로고    scopus 로고
    • Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: Systematic review and meta-analysis
    • Zhu X, Wu S, Dahut WL, Parikh CR: Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: systematic review and meta-analysis. Am J Kidney Dis 2007;49:186-193.
    • (2007) Am J Kidney Dis , vol.49 , pp. 186-193
    • Zhu, X.1    Wu, S.2    Dahut, W.L.3    Parikh, C.R.4
  • 36
    • 33749153407 scopus 로고    scopus 로고
    • Incidence and management of bevacizumab-related toxicities in colorectal cancer
    • Saif MW, Mehra R: Incidence and management of bevacizumab-related toxicities in colorectal cancer. Expert Opin Drug Saf 2006;5:553-566.
    • (2006) Expert Opin Drug Saf , vol.5 , pp. 553-566
    • Saif, M.W.1    Mehra, R.2
  • 37
    • 33846484966 scopus 로고    scopus 로고
    • Renal thrombotic microangiopathy caused by anti-VEGF-antibody treatment for metastatic renal-cell carcinoma
    • Frangie C, Lefaucheur C, Medioni J, Jacquot C, Hill GS, Nochy D: Renal thrombotic microangiopathy caused by anti-VEGF-antibody treatment for metastatic renal-cell carcinoma. Lancet Oncol 2007;8:177-178.
    • (2007) Lancet Oncol , vol.8 , pp. 177-178
    • Frangie, C.1    Lefaucheur, C.2    Medioni, J.3    Jacquot, C.4    Hill, G.S.5    Nochy, D.6
  • 38
    • 0142121282 scopus 로고    scopus 로고
    • Kilickap S, Abali H, Celik I: Bevacizumab, bleeding, thrombosis, and warfarin. J Clin Oncol 2003;21:3542; author reply 3543.
    • Kilickap S, Abali H, Celik I: Bevacizumab, bleeding, thrombosis, and warfarin. J Clin Oncol 2003;21:3542; author reply 3543.
  • 39
    • 17844373871 scopus 로고    scopus 로고
    • Thromboembolic events in gastric cancer: High incidence in patients receiving irinotecan- and bevacizumab-based therapy
    • Shah MA, Ilson D, Kelsen DP: Thromboembolic events in gastric cancer: High incidence in patients receiving irinotecan- and bevacizumab-based therapy. J Clin Oncol 2005;23:2574-2576.
    • (2005) J Clin Oncol , vol.23 , pp. 2574-2576
    • Shah, M.A.1    Ilson, D.2    Kelsen, D.P.3
  • 40
    • 33746833739 scopus 로고    scopus 로고
    • Phase II multicenter trial of bevacizumab plus fluorouracil and leucovorin in patients with advanced refractory colorectal cancer: An NCI treatment referral center trial TRC-0301
    • Chen HX, Mooney M, Boron M, Vena D, Mosby K, Grochow L, Jaffe C, Rubinstein L, Zwiebel J, Kaplan RS: Phase II multicenter trial of bevacizumab plus fluorouracil and leucovorin in patients with advanced refractory colorectal cancer: An NCI treatment referral center trial TRC-0301. J Clin Oncol 2006;24:3354-3360.
    • (2006) J Clin Oncol , vol.24 , pp. 3354-3360
    • Chen, H.X.1    Mooney, M.2    Boron, M.3    Vena, D.4    Mosby, K.5    Grochow, L.6    Jaffe, C.7    Rubinstein, L.8    Zwiebel, J.9    Kaplan, R.S.10
  • 42
    • 33845353863 scopus 로고    scopus 로고
    • Chemotherapy with bevacizumab, irinotecan, 5-fluorouracil and leucovorin (IFL) associated with a large, embolizing thrombus in the thoracic aorta
    • Yoon S, Schmassmann-Suhijar D, Zuber M, Konietzny P, Schmassmann A: Chemotherapy with bevacizumab, irinotecan, 5-fluorouracil and leucovorin (IFL) associated with a large, embolizing thrombus in the thoracic aorta. Ann Oncol 2006;17:1851-1852.
    • (2006) Ann Oncol , vol.17 , pp. 1851-1852
    • Yoon, S.1    Schmassmann-Suhijar, D.2    Zuber, M.3    Konietzny, P.4    Schmassmann, A.5
  • 45
    • 33845313345 scopus 로고    scopus 로고
    • The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; a review
    • Eskens FA, Verweij J: The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; a review. Eur J Cancer 2006;42:3127-3139.
    • (2006) Eur J Cancer , vol.42 , pp. 3127-3139
    • Eskens, F.A.1    Verweij, J.2
  • 47
    • 34247169465 scopus 로고    scopus 로고
    • Sunitinib and hypothyroidism
    • author reply 1580-1581
    • Wolter P, Dumez H, Schoffski P: Sunitinib and hypothyroidism. N Engl J Med 2007;356:1580; author reply 1580-1581.
    • (2007) N Engl J Med , vol.356 , pp. 1580
    • Wolter, P.1    Dumez, H.2    Schoffski, P.3
  • 48
    • 36549031784 scopus 로고    scopus 로고
    • Unanswered questions regarding the management of sunitinibinduced hypothyroidism
    • Garfield D, Hercbergs A, Davis P: Unanswered questions regarding the management of sunitinibinduced hypothyroidism. Nat Clin Pract Oncol 2007;4:674.
    • (2007) Nat Clin Pract Oncol , vol.4 , pp. 674
    • Garfield, D.1    Hercbergs, A.2    Davis, P.3
  • 49
    • 0031967581 scopus 로고    scopus 로고
    • Presence and possible role of vascular endothelial growth factor in thyroid cell growth and function
    • Wang JF, Milosveski V, Schramek C, Fong GH, Becks GP, Hill DJ: Presence and possible role of vascular endothelial growth factor in thyroid cell growth and function. J Endocrinol 1998;157:5-12.
    • (1998) J Endocrinol , vol.157 , pp. 5-12
    • Wang, J.F.1    Milosveski, V.2    Schramek, C.3    Fong, G.H.4    Becks, G.P.5    Hill, D.J.6
  • 53
    • 34547654541 scopus 로고    scopus 로고
    • Phase I dose escalation and pharmacokinetic study of AZD2171, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinase, in patients with hormone refractory prostate cancer (HRPC)
    • Ryan CJ, Stadler WM, Roth B, Hutcheon D, Conry S, Puchalski T, Morris C, Small EJ: Phase I dose escalation and pharmacokinetic study of AZD2171, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinase, in patients with hormone refractory prostate cancer (HRPC). Invest New Drugs 2007;25:445-451.
    • (2007) Invest New Drugs , vol.25 , pp. 445-451
    • Ryan, C.J.1    Stadler, W.M.2    Roth, B.3    Hutcheon, D.4    Conry, S.5    Puchalski, T.6    Morris, C.7    Small, E.J.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.