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Volumn 12, Issue 1, 2009, Pages 43-50

Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial (ONTARGET): Implications for reduced cardiovascular risk

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INOTROPIC AGENT; LOSARTAN; PLACEBO; RAMIPRIL; TELMISARTAN; VALSARTAN; VASODILATOR AGENT; BENZIMIDAZOLE DERIVATIVE; BENZOIC ACID DERIVATIVE;

EID: 63849189587     PISSN: 1520037X     EISSN: 17517141     Source Type: Journal    
DOI: 10.1111/j.1751-7141.2008.00010.x     Document Type: Review
Times cited : (16)

References (38)
  • 1
    • 18744380400 scopus 로고    scopus 로고
    • The ONTARGET/TRANSCEND Trial Programme: baseline data
    • Sleight P. The ONTARGET/TRANSCEND Trial Programme: baseline data. Acta Diabetol 2005, 42:S50-S56.
    • (2005) Acta Diabetol , vol.42
    • Sleight, P.1
  • 2
    • 42049107348 scopus 로고    scopus 로고
    • Telmisartan, ramipril, or both in patients at high risk for vascular events
    • Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med. 2008, 358:1547-1559.
    • (2008) N Engl J Med. , vol.358 , pp. 1547-1559
  • 3
    • 50549091800 scopus 로고    scopus 로고
    • Clinical Trial Update: ENHANCE and ONTARGET
    • Liebson PR. Clinical Trial Update: ENHANCE and ONTARGET. Prev Cardiol. 2008, 11:179-182.
    • (2008) Prev Cardiol. , vol.11 , pp. 179-182
    • Liebson, P.R.1
  • 4
    • 47649125502 scopus 로고    scopus 로고
    • RAS blockade with ARB and ACE inhibitors: current perspective on rationale and patient selection
    • [Epub]
    • Werner C, Baumhäkel M, Teo KK. RAS blockade with ARB and ACE inhibitors: current perspective on rationale and patient selection. Clin Res Cardiol. 2008, 3:418-431. [Epub]
    • (2008) Clin Res Cardiol. , vol.3 , pp. 418-431
    • Werner, C.1    Baumhäkel, M.2    Teo, K.K.3
  • 5
    • 0021265674 scopus 로고
    • Evidence for a putatively new angiotensin-II generating enzyme in the vascular wall
    • Okunishu H, Miyazaki M, Toda N. Evidence for a putatively new angiotensin-II generating enzyme in the vascular wall. J Hypertens. 1984, 2:277-284.
    • (1984) J Hypertens. , vol.2 , pp. 277-284
    • Okunishu, H.1    Miyazaki, M.2    Toda, N.3
  • 6
    • 0037154324 scopus 로고    scopus 로고
    • The AT (1)-type angiotensin receptor in oxidative stress and atherogenesis. Part I: oxidative stress and atherogenesis
    • Nickenig G, Harrison DG. The AT (1)-type angiotensin receptor in oxidative stress and atherogenesis. Part I: oxidative stress and atherogenesis. Circulation. 2002, 105:393-396.
    • (2002) Circulation. , vol.105 , pp. 393-396
    • Nickenig, G.1    Harrison, D.G.2
  • 7
    • 33745530252 scopus 로고    scopus 로고
    • Pathophysiological regulation of the AT1-receptor and Implications for vascular disease
    • Wassman S, Nickenig G. Pathophysiological regulation of the AT1-receptor and Implications for vascular disease. J Hypertens. 2006, 24:S15-S21.
    • (2006) J Hypertens. , vol.24
    • Wassman, S.1    Nickenig, G.2
  • 8
    • 0035818917 scopus 로고    scopus 로고
    • Aldosterone in congestive heart failure
    • Weber KT. Aldosterone in congestive heart failure. N Engl J Med. 2001, 345:1689-1697.
    • (2001) N Engl J Med. , vol.345 , pp. 1689-1697
    • Weber, K.T.1
  • 9
    • 0034688194 scopus 로고    scopus 로고
    • Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high risk patients
    • Yusuf S. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high risk patients. N Engl J Med. 2000, 342:145-153.
    • (2000) N Engl J Med. , vol.342 , pp. 145-153
    • Yusuf, S.1
  • 10
    • 0034700790 scopus 로고    scopus 로고
    • Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy
    • Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Lancet. 2000, 355:253-259.
    • (2000) Lancet. , vol.355 , pp. 253-259
  • 11
    • 0042330455 scopus 로고    scopus 로고
    • Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicenter trial (the EUROPA study)
    • Fox KM. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicenter trial (the EUROPA study). Lancet. 2003, 362:782-788.
    • (2003) Lancet. , vol.362 , pp. 782-788
    • Fox, K.M.1
  • 12
    • 19644400972 scopus 로고    scopus 로고
    • Angiotensin-converting-enzyme inhibition in stable coronary artery disease
    • [PEACE trial]
    • Braunwald E, Domanski MJ, Fowler SE. Angiotensin-converting-enzyme inhibition in stable coronary artery disease. N Engl J Med. 2004, 351:2058-2068. [PEACE trial]
    • (2004) N Engl J Med. , vol.351 , pp. 2058-2068
    • Braunwald, E.1    Domanski, M.J.2    Fowler, S.E.3
  • 13
    • 34547129852 scopus 로고    scopus 로고
    • Rationale for double renin-angiotensin-aldosterone system blockade
    • Unger T, Stoppelhaar M. Rationale for double renin-angiotensin-aldosterone system blockade. Am J Cardiol. 2007, 100:25J-31J.
    • (2007) Am J Cardiol. , vol.100
    • Unger, T.1    Stoppelhaar, M.2
  • 14
    • 15744392514 scopus 로고    scopus 로고
    • Stimulation of endothelial progenitor cells: a new putative therapeutic effect of angiotensin II receptor antagonists
    • Bahlmann FH, deGroot K, Mueller O. Stimulation of endothelial progenitor cells: a new putative therapeutic effect of angiotensin II receptor antagonists. Hypertension. 2005, 45:526-529.
    • (2005) Hypertension. , vol.45 , pp. 526-529
    • Bahlmann, F.H.1    deGroot, K.2    Mueller, O.3
  • 15
    • 33846623798 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets
    • Brown JD, Plutzky J. Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets. Circulation. 2007, 115:518-533.
    • (2007) Circulation. , vol.115 , pp. 518-533
    • Brown, J.D.1    Plutzky, J.2
  • 16
    • 0035922441 scopus 로고    scopus 로고
    • Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    • Brenner BM, Cooper ME, de Zeeuw D. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med. 2001, 345:861-869.
    • (2001) N Engl J Med. , vol.345 , pp. 861-869
    • Brenner, B.M.1    Cooper, M.E.2    de Zeeuw, D.3
  • 17
    • 0035922447 scopus 로고    scopus 로고
    • Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
    • Lewis EJ, Hunsicker LG, Clarke WR. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med. 2001, 345:851-860.
    • (2001) N Engl J Med. , vol.345 , pp. 851-860
    • Lewis, E.J.1    Hunsicker, L.G.2    Clarke, W.R.3
  • 18
    • 34249869003 scopus 로고    scopus 로고
    • Impact of telmisartan versus ramipril on renal endothelial function in patients with hypertension and type 2 diabetes
    • Schmieder RE, Delles C, Mimran A. Impact of telmisartan versus ramipril on renal endothelial function in patients with hypertension and type 2 diabetes. Diabetes Care. 2007, 30:1351-1356.
    • (2007) Diabetes Care. , vol.30 , pp. 1351-1356
    • Schmieder, R.E.1    Delles, C.2    Mimran, A.3
  • 19
    • 7444237666 scopus 로고    scopus 로고
    • Angiotensin-receptor blockade versus converting-enzyme inhibition in type 2 diabetes and nephropathy
    • Barnett AH, Bain SC, Bouter P. Angiotensin-receptor blockade versus converting-enzyme inhibition in type 2 diabetes and nephropathy. N Engl J Med. 2004, 351:1952-1961.
    • (2004) N Engl J Med. , vol.351 , pp. 1952-1961
    • Barnett, A.H.1    Bain, S.C.2    Bouter, P.3    et al4
  • 20
    • 0041909380 scopus 로고    scopus 로고
    • Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial
    • Granger CB, McMurray JJ, Yusuf S. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial. Lancet. 2003, 362A:772-776.
    • (2003) Lancet. , vol.362 A , pp. 772-776
    • Granger, C.B.1    McMurray, J.J.2    Yusuf, S.3
  • 21
    • 0037120958 scopus 로고    scopus 로고
    • Effects of valsartan on morbidity and mortality in patients with heart failure not receiving angiotensin-converting enzyme inhibitors
    • Maggioni AP, Anand I, Gottlieb SO. Effects of valsartan on morbidity and mortality in patients with heart failure not receiving angiotensin-converting enzyme inhibitors. J Am Coll Cardiol. 2002, 40:1414-1421.
    • (2002) J Am Coll Cardiol. , vol.40 , pp. 1414-1421
    • Maggioni, A.P.1    Anand, I.2    Gottlieb, S.O.3
  • 22
    • 0041408234 scopus 로고    scopus 로고
    • Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved trial
    • Yusuf S, Pfeffer MA, Swedberg K. Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved trial. Lancet. 2003, 362:777-781.
    • (2003) Lancet. , vol.362 , pp. 777-781
    • Yusuf, S.1    Pfeffer, M.A.2    Swedberg, K.3
  • 23
    • 0034612118 scopus 로고    scopus 로고
    • Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomized trial - the Losartan Heart Failure Survival study ELITE II
    • Pitt B, Poole-Wilson PA, Segal R. Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomized trial - the Losartan Heart Failure Survival study ELITE II. Lancet. 2000, 355:1582-1587.
    • (2000) Lancet. , vol.355 , pp. 1582-1587
    • Pitt, B.1    Poole-Wilson, P.A.2    Segal, R.3
  • 24
    • 0242490542 scopus 로고    scopus 로고
    • Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both
    • Pfeffer MA, McMurray JJ, Velazquez EJ. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med. 2003, 349:1893-1906.
    • (2003) N Engl J Med. , vol.349 , pp. 1893-1906
    • Pfeffer, M.A.1    McMurray, J.J.2    Velazquez, E.J.3
  • 25
    • 0041408235 scopus 로고    scopus 로고
    • Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial
    • McMurray JJ, Ostergren J, Swedberg K. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial. Lancet. 2003, 362:767-771.
    • (2003) Lancet. , vol.362 , pp. 767-771
    • McMurray, J.J.1    Ostergren, J.2    Swedberg, K.3
  • 26
    • 0035818884 scopus 로고    scopus 로고
    • Valsartan Heart Failoure Trial Investigators. A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure
    • Cohn JN, Tognoni G. Valsartan Heart Failoure Trial Investigators. A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. N Engl J Med. 2001, 345:1667-1675.
    • (2001) N Engl J Med. , vol.345 , pp. 1667-1675
    • Cohn, J.N.1    Tognoni, G.2
  • 27
    • 0033533456 scopus 로고    scopus 로고
    • Comparison of candesartan, enalapril, and their combination in congestive heart failure: Randomized Evaluation of Strategies for Left Ventricular Dysfunction (RESOLVD) pilot study
    • McKelvie RS, Yusuf S, Pericak D. Comparison of candesartan, enalapril, and their combination in congestive heart failure: Randomized Evaluation of Strategies for Left Ventricular Dysfunction (RESOLVD) pilot study. Circulation. 1999, 100:1056-1064.
    • (1999) Circulation. , vol.100 , pp. 1056-1064
    • McKelvie, R.S.1    Yusuf, S.2    Pericak, D.3
  • 28
    • 32644482770 scopus 로고    scopus 로고
    • The effect of valsartan, captopril, or both on atherosclerotic events after myocardial infarction
    • McMurray J, Solomon S, Pieper K. The effect of valsartan, captopril, or both on atherosclerotic events after myocardial infarction. J Am Coll Cardiol. 2006, 47:726-733.
    • (2006) J Am Coll Cardiol. , vol.47 , pp. 726-733
    • McMurray, J.1    Solomon, S.2    Pieper, K.3
  • 29
    • 0037036971 scopus 로고    scopus 로고
    • Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomized trial
    • Dickstein K, Kjekshus J. Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomized trial. Lancet. 2002, 360:752-760.
    • (2002) Lancet. , vol.360 , pp. 752-760
    • Dickstein, K.1    Kjekshus, J.2
  • 30
    • 7244227872 scopus 로고    scopus 로고
    • Meta-analysis: angiotensin-receptor blockers in chronic heart failure and high-risk acute myocardial infarction
    • Lee VC, Rhew DC, Dylan M. Meta-analysis: angiotensin-receptor blockers in chronic heart failure and high-risk acute myocardial infarction. Ann Int Med. 2004, 141:693-704.
    • (2004) Ann Int Med. , vol.141 , pp. 693-704
    • Lee, V.C.1    Rhew, D.C.2    Dylan, M.3
  • 31
    • 35348976721 scopus 로고    scopus 로고
    • Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from randomized clinical trials
    • Phillips CO, Kashani A, Ko DK. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from randomized clinical trials. Arch Int Med. 2007, 167:1930-1936.
    • (2007) Arch Int Med. , vol.167 , pp. 1930-1936
    • Phillips, C.O.1    Kashani, A.2    Ko, D.K.3
  • 32
    • 42549125725 scopus 로고    scopus 로고
    • Cardiac and vascular protection: the potential of ONTARGET
    • Mancia G, Jakobsen A, Heroys J. Cardiac and vascular protection: the potential of ONTARGET. Medscape J Med. 2008, 10.
    • (2008) Medscape J Med. , vol.10
    • Mancia, G.1    Jakobsen, A.2    Heroys, J.3
  • 33
    • 10344249378 scopus 로고    scopus 로고
    • Antidiabetic mechanisms of ACE inhibitors and AII receptor antagonists: beyond the renin-angiotensin system
    • Kurtz TW, Pravenek M. Antidiabetic mechanisms of ACE inhibitors and AII receptor antagonists: beyond the renin-angiotensin system. J Hypertens. 2004, 22:2253-2261.
    • (2004) J Hypertens. , vol.22 , pp. 2253-2261
    • Kurtz, T.W.1    Pravenek, M.2
  • 34
    • 33846976548 scopus 로고    scopus 로고
    • The effects of irbesartan and telmisartan on metabolic parameters and blood pressure in obese, insulin resistant, hypertensive patients
    • Negro R, Formoso G, Hassan H. The effects of irbesartan and telmisartan on metabolic parameters and blood pressure in obese, insulin resistant, hypertensive patients. J Endocrinol Invest. 2006, 29:957-961.
    • (2006) J Endocrinol Invest. , vol.29 , pp. 957-961
    • Negro, R.1    Formoso, G.2    Hassan, H.3
  • 35
    • 4344569280 scopus 로고    scopus 로고
    • Effects of telmisartan compared eprosartan on blood pressure control. Glucose metabolism and lipid profile in hypertensive, type 2 diabetic patients: a randomized, double-blind, placebo-controlled 12 month study
    • De Rosa G, Ragonesi PD, Mugellini A. Effects of telmisartan compared eprosartan on blood pressure control. Glucose metabolism and lipid profile in hypertensive, type 2 diabetic patients: a randomized, double-blind, placebo-controlled 12 month study. Hypertens Res. 2004, 27:457-464.
    • (2004) Hypertens Res. , vol.27 , pp. 457-464
    • De Rosa, G.1    Ragonesi, P.D.2    Mugellini, A.3
  • 36
    • 42049084174 scopus 로고    scopus 로고
    • ACE inhibitors in cardiovascular disease-unbeatable?
    • McMurray JJV. ACE inhibitors in cardiovascular disease-unbeatable?. N Engl J Med. 2008, 358:1615-1616.
    • (2008) N Engl J Med. , vol.358 , pp. 1615-1616
    • McMurray, J.J.V.1
  • 37
    • 3142740224 scopus 로고    scopus 로고
    • ONTARGET/TRANSCEND Investigators. Rationale, design characteristics of 2 large, simple, randomized trials evaluating telmisartan, ramipril, and their combination risk patients; the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Randomized Assessment Study in ACE intolerant Subjects with Cardiovascular Disease (ONTARGET/TRANSCEND) trials
    • Teo K, Yusuf S, Anderson C. ONTARGET/TRANSCEND Investigators. Rationale, design characteristics of 2 large, simple, randomized trials evaluating telmisartan, ramipril, and their combination risk patients; the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Randomized Assessment Study in ACE intolerant Subjects with Cardiovascular Disease (ONTARGET/TRANSCEND) trials. Am Heart J. 2004, 148:52-61.
    • (2004) Am Heart J. , vol.148 , pp. 52-61
    • Teo, K.1    Yusuf, S.2    Anderson, C.3    et al4
  • 38
    • 38349053972 scopus 로고    scopus 로고
    • Clinical trial update: focus on the ONTARGET study
    • Fitchett D. Clinical trial update: focus on the ONTARGET study. Vas Health Risk Manag. 2007, 3:901-908.
    • (2007) Vas Health Risk Manag. , vol.3 , pp. 901-908
    • Fitchett, D.1


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