Effects of environmental enrichment on the amyotrophic lateral sclerosis mouse model

Laboratory Animals

Volumn 43, Issue 2, 2009, Pages 182-190

  Sorrells, A D ^a   Corcoran Gomez, K ^a   Eckert, K A ^a,b   Fahey, A G ^c   Hoots, B L ^a   Charleston, L B ^d   Charleston, J S ^d   Roberts, C R ^a   Markowitz, H ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO STATE UNIVERSITY   (United States)

^c PURDUE UNIVERSITY   (United States)

^d StereoTome NW ^*  (United States)

Author keywords

Amyotrophic lateral sclerosis (ALS); Animal wellbeing; Environmental enrichment; Exercise; Mice

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE;

ALPHA NERVE FIBER; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL HOUSING; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAGE; CONDITIONING; CONTROLLED STUDY; DISEASE COURSE; ENVIRONMENTAL ENRICHMENT; EXERCISE; EXPERIMENTAL MODEL; EXPERIMENTAL MOUSE; FORCED CHOICE METHOD; LIFESPAN; MALE; MEDICAL RESEARCH; MOUSE; MOUSE STRAIN; MOUSE STRAIN SOD1; NONHUMAN; TASK PERFORMANCE; TREADMILL;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; GAIT; HOUSING, ANIMAL; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR NEURONS; PHYSICAL CONDITIONING, ANIMAL; RANDOM ALLOCATION; SPINAL CORD;

ANIMALIA; MUS; MUS MUSCULUS; RODENTIA;

EID: 63849120127     PISSN: 00236772     EISSN: None     Source Type: Journal    
DOI: 10.1258/la.2008.005090     Document Type: Article

References (45)

1. van de Weerd HA, van Loo PL, van Zutphen LF, Koolhaus JM, Baumans V. Preferences for nesting material as environmental enrichment for laboratory mice. Lab Anim 1997;31:133-43
2. Markowitz H, Gavazzi A. Eleven principles for improving the quality of captive animal life. Lab Animal 1995;24:30-3
3. Benn DM. Innovations in research animal care. J Am Vet Med Assoc 1995;206:465-8
4. Markowitz H, Line S. The need for responsive environments. In: Rollin BE, ed. The Experimental Animal in Biomedical Research. Vol. 1. Florida: CRC Press, 1990:153-70
5. Reinhardt V, Reinhardt A. Environmental Enrichment for Caged Rhesus Macaques (Macaca mulatta) - Photographic Documentation and Literature Review. 2nd edn. Washington DC: Animal Welfare Institute, 2001
6. Jensen P, Toates FM. Who needs 'behavioural needs'? Motivational aspects of the needs of animals. Appl Anim Behav Sci 1993;37:161-81
7. Chamove AS. Cage design reduces emotionality in mice. Lab Anim 1989;23:215-19
8. Poole TB. The nature and evolution of behavioural needs in mammals. Anim Welf 1992;1:203-20
9. Spinelli JS, Markowitz H. Prevention of cage associated distress. Lab Anim 1985;14:19-24
10. Wemelsfelder F. Boredom and laboratory animal welfare. In: Rollin BE, ed. The Experimental Animal in Biomedical Research. Vol. 1. Florida: CRC Press, 1990:234-72
11. Ferin M, Carmel PW, Warren MP, Himsworth RL, Frantz AG. Phencyclidine sedation as a technique for handling rhesus monkeys: effects on LH, GH, and prolactin secretion. Proc Soc Exp Biol Med 1976;151:428-33
12. Brockway BP, Hassler CR, Hicks N. Minimizing stress during physiological monitoring. In: Niemi SM, Willson JE, eds. Refinement and Reduction in Animal Testing. Greenbelt: Scientists Center for Animal Welfare, 1993:56-69
13. Fuchs E. Requirements of biomedical research in terms of housing and husbandry: neuroscience. Primate Rep 1997;49:43-6
14. Garner JP, Mason GJ. Evidence for a relationship between cage stereotypies and behavioural disinhibition in laboratory rodents. Behav Brain Res 2002;136:83-92
15. Sherwin CM. Comfortable quarters for mice. In: Reinhardt V, Reinhardt K, eds. Comfortable Quarters for Animals. Washington DC: Animal Welfare Institute, 2002:6-17 (http://www.awionline.org/pubs/cq02/cqindex. html)
16. Olsson IAS, Nevison CM, Patteson-Kane E, Sherwin CM, van de Weerd HA, Würbel H. Understanding behaviour: the relevance of ethological approaches in laboratory animal science. Appl Anim Behav Sci 2003;81:245 - 64
17. Crabbe JC, Wahlsten D, Dudek BC. Genetics of mouse behavior: interactions with laboratory environment. Science 1999;284:1670-2
18. Würbel H. Behavioural phenotyping enhanced - beyond (environmental) standardization. Genes Brain Behav 2002;1:3-8
19. Hockley E, Cordery PM, Woodman B, et al. Environmental enrichment slows disease progression in R6/2 Huntington's disease mice. Ann Neurol 2002;51:235 -42
20. Lazarov O, Robinson J, Tang YP, et al. Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell 2005;120:701-13
21. Guilarte TR, Toscano CD, McGlothan JL, Weaver SA. Environmental enrichment reverses cognitive and molecular deficits induced by developmental lead exposure. Ann Neurol 2003;53:50-6
22. Rowland LP. Amyotrophic lateral sclerosis: human challenge for neuroscience. Proc Natl Acad Sci 1995;92:1251 -3
23. Gurney ME. What transgenic mice tell us about neurodegenerative disease. BioEssays 2000;22:297-304
24. Rosen DR, Siddique T, Patterson D, et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993;362:59-62
25. Deng HX, Hentati A, Tainer JA, et al. Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. Science 1993;261:1047-51
26. Ripps ME, Huntley GW, Hof PR, Morrison JH, Gordon JW. Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc Natl Acad Sci 1995;92:689- 93
27. Chiu AY, Zhai P, Dal Canto MC, et al. Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis. Mol Cell Neurosci 1995;6:349-62
28. Francis K, Bach JR, DeLisa JA. Evaluation and rehabilitation of patients with adult motor neuron disease. Arch Phys Med Rehab 1999;80:951 -63
29. Drory VE, Goltsman E, Reznik JG, Mosek A, Korczyn AD. The value of muscle exercise in patients with amyotropic lateral sclerosis. J Neurol Sci 2001;19:133-7
30. Mullenix P, Norton S, Culver B. Locomotor damage in rats after X-irradiation in utero. Exp Neurol 1975;82:310-24
31. Charleston JS. Morphometric analysis of cell number in the central nervous system. In: Costa L, ed. Current Protocols in Toxicology. New York, NY: John Wiley and Sons, 2000: Unit 12:6
32. Gundersen HJG, Bagger P, Bendtsen TF, et al. The new stereological tools: dissector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. A'P'MIS 1988;96:857-81
33. West MJ, Slomianka L, Gundersen HJG. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 1991;231:482-97
34. West MJ. New stereological methods for counting neurons. Neurobiol Aging 1993;14:275-85
35. Bjugn R, Gundersen HJG. Estimate of the total number of neurons and glial and endothelial cells in the rat spinal cord by means of the optical dissector. J Comp Neurol 1993;328:406-14
36. West MJ, Gundersen HJG. Unbiased stereological estimation of the number of neurons in the human hippocampus. J Comp Neurol 1990;296:1-22
37. Sherwin CM. Voluntary wheel-running: a review and novel interpretation. Anim Behav 1998;56:11-27
38. Fischer FR, Peduzzi JD. Functional improvement in rats with chronic spinal cord injuries after exposure to an enriched environment. Soc Neurosci Abstr 1997;23:2188
39. Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995;12:1-21
40. Zhang DW, Cheema SS. Degeneration of corticospinal and bulbospinal systems in the superoxide dismutase 1 G93aAG1H transgenic mouse model of familial amyotrophic lateral sclerosis. Neurosci Lett 2002;332:99-102
41. Ciavarro GL, Calvaresi N, Botturi A, Bendotti C, Andreoni G, Pedotti A. The densitometric physical fractionator for counting neuronal populations: application to a mouse model of familial amyotrophic lateral sclerosis. J Neurosci Methods 2003;129:61-71
42. Gredal O, Pakkenberg H, Karlsborg M, Pakkenberg B. Unchanged total number of neurons in motor cortex and neocortex in amyotrophic lateral sclerosis: a stereological study. J Neurosci Methods 2000;95:171 -6
43. Augustsson H, van de Weerd HA, Kruitwagen CLJJ, Baumans V. Effects of enrichment on variation and results in the light/dark test. Lab Anim 2003;37:328-40
44. Barnard J, Behnke JM, Siegel J. Environmental enrichment, immunocompetence, and resistance to Babesia microti in male mice. Physiol Behav 1999;60:1223-31
45. Olsson AS, Dahlborn K. Improving housing conditons for laboratory mice: a review of environmental enrichment. Lab Anim 2002;36:243-70