Plasma homocysteine and cerebrospinal fluid neurodegeneration biomarkers in mild cognitive impairment and dementia

Journal of the American Geriatrics Society

Volumn 57, Issue 4, 2009, Pages 737-739

  Alexopoulos, Panagiotis ^a,b   Günther, Florian ^a   Popp, Julius ^c   Jessen, Frank ^c   Peters, Oliver ^d   Wolf, Stefanie ^e   Kneib, Thomas ^f   Kurz, Alexander ^b   Richter Schmidinger, Tanja ^a   Lewczuk, Piotr ^a   Bleich, Stefan ^a,g   Wiltfang, Jens ^h   Kornhuber, Johannes ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF BONN   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e UNIVERSITY OF GÖTTINGEN   (Germany)

^f UNIVERSITY OF MUNICH   (Germany)

^g HANNOVER MEDICAL SCHOOL   (Germany)

^h UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; BIOLOGICAL MARKER; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; TAU PROTEIN;

AGED; AMINO ACID BLOOD LEVEL; BLOOD SAMPLING; CEREBROSPINAL FLUID; COGNITIVE DEFECT; DEGENERATIVE DISEASE; DEMENTIA; DISEASE ASSOCIATION; FEMALE; HUMAN; LABORATORY TEST; LETTER; LUMBAR PUNCTURE; MAJOR CLINICAL STUDY; MALE; MULTIPLE LINEAR REGRESSION ANALYSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENESIS; RADIOIMMUNOASSAY;

AGED; AMYLOID BETA-PROTEIN; BIOLOGICAL MARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CREATININE; DEMENTIA; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLIC ACID; GERMANY; HOMOCYSTEINE; HUMANS; IMMUNOASSAY; LINEAR MODELS; MALE; MIDDLE AGED; NEPHELOMETRY AND TURBIDIMETRY; NERVE DEGENERATION; PEPTIDE FRAGMENTS; TAU PROTEINS; VITAMIN B 12;

EID: 63849113918     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2009.02212.x     Document Type: Letter

References (10)

1. Kessler H, Bleich S, Falkai P et al. Homocysteine and dementia. Fortschr Neurol Psychiatr 2003 71 : 150 156.
2. Irizarry MC, Gurol ME, Raju S et al. Association of homocysteine with plasma amyloid beta protein in aging and neurodegenerative disease. Neurology 2005 65 : 1402 1408.
3. Obeid R, Kasoha M, Knapp JP et al. Folate and methylation status in relation to phosphorylated tau protein(181P) and beta-amyloid(1-42) in cerebrospinal fluid. Clin Chem 2007 53 : 1129 1136.
4. Kornhuber J, Schmidtke K, Frölich L et al. Early and differential diagnosis of dementia and MCI: Design and cohort baseline characteristics of the German Dementia Competence Network. Dement Geriatr Cogn Disord 2009 in press.
5. Petersen RC, Doody R, Kurz A et al. Current concepts in mild cognitive impairment. Arch Neurol 2001 58 : 1985 1892.
6. Zappacosta B, Persichilli S, Schribano D et al. Comparing different methods for homocysteine determination. Clin Chem Lab Med 2002 40 : 1139 1142.
7. Selley ML, Close DR, Stern SE. The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and the cerebrospinal fluid of patients with Alzheimer's disease. Neurobiol Aging 2002 3 : 383 388.
8. Mehta PD, Pirttila T, Patrick BA et al. Amyloid beta protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease. Neurosci Lett 2001 304 : 102 106.
9. Clarke R, Woodhouse P, Ulvik A et al. Variability and determinants of total homocysteine concentrations in plasma in an elderly population. Clin Chem 1998 44 : 102 107.
10. Thirup P, Ekelund S. Day-to-day, postprandial, and orthostatic variation of total plasma homocysteine. Clin Chem 1999 45 : 1280 1283.