Reducing variation in a rabbit vaccine safety study with particular emphasis on housing conditions and handling

Laboratory Animals

Volumn 43, Issue 2, 2009, Pages 155-164

  Verwer, Cynthia M ^a   Van Ark, Arno Der ^b   Van Amerongen, Geert ^b   Van Bos, Ruud Den ^a   Hendriksen, Coenraad F M ^a,b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b NETHERLANDS VACCINE INSTITUTE   (Netherlands)

Author keywords

Body temperature; Handling; Housing conditions; Pertussis whole cell vaccine; Rabbit; Reduction; Refinement

Indexed keywords

PERTUSSIS VACCINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL HOUSING; ARTICLE; BLOOD SAMPLING; BODY TEMPERATURE; CAGE; CIRCADIAN RHYTHM; CLEANING; CONDITIONING; CONTROLLED STUDY; DOSE RESPONSE; DRUG SAFETY; EXPERIMENTAL ANIMAL; EXPERIMENTAL STUDY; HABITUATION; INOCULATION; MALE; MONITORING; NONHUMAN; OUTCOME ASSESSMENT; PARAMETER; RABBIT;

ANIMALS; ANTIBODIES, BACTERIAL; BLOOD CELL COUNT; BODY TEMPERATURE; BODY WEIGHT; DIPHTHERIA-TETANUS-PERTUSSIS VACCINE; FEMALE; HANDLING (PSYCHOLOGY); HEMATOCRIT; HEMOGLOBINS; HOUSING, ANIMAL; HUMANS; MALE; MODELS, ANIMAL; RABBITS; RANDOM ALLOCATION; TELEMETRY; TOXICITY TESTS;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 63849088874     PISSN: 00236772     EISSN: None     Source Type: Journal    
DOI: 10.1258/la.2008.007134     Document Type: Article

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