Radiation dose to trabecular bone marrow stem cells from 3H, 14C and selected α-emitters incorporated in a bone remodeling compartment

Physics in Medicine and Biology

Volumn 54, Issue 4, 2009, Pages 963-979

  Nie, Huiling ^a,b   Richardson, Richard B ^c  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c ATOMIC ENERGY OF CANADA LIMITED   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORBED DOSE; BONE CANCERS; BONE REMODELING; BONE SURFACES; ENERGY RANGES; INTERNATIONAL COMMISSION ON RADIOLOGICAL PROTECTIONS; MEAN DOSE; MICROENVIRONMENT; MONTE CARLO SIMULATIONS; OXYGEN EFFECTS; PROGENITOR CELLS; RADIATION DOSE; RADIATION-INDUCED CANCERS; SIMULATION RESULTS; STATIC MODELS; STEM CELLS; STEM-CELL NICHES; TARGET VOLUMES; TRABECULAR BONES;

BIOLOGICAL RADIATION EFFECTS; BONE; CYTOLOGY; DOSIMETRY; ECOLOGY; MONTE CARLO METHODS; OXYGEN; RADIATION; RADIATION PROTECTION; SURFACES; TARGETS;

CELLS;

CARBON 14; TRITIUM;

ARTICLE; BONE CANCER; BONE REMODELING; CANCER RISK; HEMATOPOIETIC STEM CELL; MICROENVIRONMENT; MONTE CARLO METHOD; OXYGENATION; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; RADIOSENSITIZATION; TRABECULAR BONE;

ALPHA PARTICLES; BONE AND BONES; BONE REMODELING; CARBON RADIOISOTOPES; COMPUTER SIMULATION; DEUTERIUM; DOSE-RESPONSE RELATIONSHIP, RADIATION; HEMATOPOIETIC STEM CELLS; HUMANS; MODELS, BIOLOGICAL; RADIATION DOSAGE; RELATIVE BIOLOGICAL EFFECTIVENESS;

EID: 63649150841     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/54/4/010     Document Type: Article

References (40)

1. Allen J E, Henshaw D L, Keitch P A, Fews A P and Eatough J P 1995 Fat cells in red bone marrow of human rib: their size and spatial distribution with respect to the radon-derived dose to the haemopoietic tissue Int. J. Radiat. Biol. 68 669-78
2. Arai F, Hirao A and Suda T 2005 Regulation of hematopoiesis and its interaction with stem cell niches Int. J. Hematol. 82 371-6
3. Barendsen G W, Coot C J, Van Kersen O R, Bewley D K, Field S B and Parnell C J 1966 The effect of oxygen on impairment of the proliferative capacity of human cells in culture by ionising radiations of different LET Int. J. Radiat. Biol. 10 317-27
4. Beddoe A H, Darley P J and Spiers F W 1976 Measurements of trabecular bone structure in man Phys. Med. Biol. 21 589-607
5. BEIR IV 1988 Health effects of radon and other internally deposited alpha-emitters Committee on the Biological Effects of Ionizing Radiation, National Research Council (Washington, DC: National Academy Press)
6. Chow D C, Wenning L A, Miller W M and Papoutsakis E T 2001 Modeling pO(2) distributions in the bone marrow hematopoietic compartment: I. Krogh's model Biophys. J. 81 675-84
7. Cross W G, Ing H and Freedman N 1983 A short atlas of beta-ray spectra Phys. Med. Biol. 28 1251-60
8. Eriksen E F 1986 Normal and pathological remodeling of human trabecular bone: three dimensional reconstruction of the remodeling sequence in normals and in metabolic bone disease Endocr. Rev. 7 379-408
9. Gössner W 2003 Target cells in internal dosimetry Radiat. Prot. Dosim. 105 39-42
10. Guldberg R E, Lin A S, Coleman R, Robertson G and Duvall C 2004 Microcomputed tomography imaging of skeletal development and growth Birth Defects Res. C Embryo Today 72 250-9
11. Gurney J G, Swensen A R and Bulterys M 1999 Malignant bone tumours Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975-1995 ed L A G Ries, M A Smith, J G Gurney, M Linet, T Tamra, J L Young and G R Bunin NIH Pub. no. 99-4649 (Bethesda, MD: National Cancer Institute, SEER Program) pp 17-34
12. Harrison J D and Muirhead C R 2003 Quantitative comparisons of cancer induction in humans by internally deposited radionuclides and external radiation Int. J. Radiat. Biol. 79 1-13
13. Harrison J S, Rameshwar P, Chang V and Bandari P 2002 Oxygen saturation in the bone marrow of healthy volunteers Blood 99 394
14. Hauge E M, Qvesel D, Eriksen E F, Mosekilde L and Melsen F 2001 Cancellous bone remodeling occurs in specialized compartments lined by cells expressing osteoblastic markers J. Bone Miner. Res. 16 1575-82
15. ICRP 1979 Limits for Intakes of Radionuclides by Workers ICRP Publication 30, Part 1 Ann. ICRP 2 (3/4) (Oxford: Pergamon)
16. ICRP 1995 Basic Anatomical and Physiological Data for Use in Radiological Protection: The Skeleton ICRP Publication 70 (Oxford: Pergamon)
17. ICRP 2007 Commission on Radiological Protection: Summary of the Recommendations ICRP Publication 103 (Oxford: Pergamon)
18. Jee W S S 2001 Integrated Bone Tissue Physiology: Anatomy and Physiology Bone Mechanics Handbook 2nd edn ed S C Cowin (Boca Raton, FL: CRC Press) pp 1-53
19. Kopp H G, Avecilla S T, Hooper A T and Rafii S 2005 The bone marrow vascular niche: home of HSC differentiation and mobilization Physiology (Bethesda) 20 349-56
20. Kvinnsland Y, Skretting A and Bruland O S 2001 Radionuclide therapy with bone-seeking compounds: Monte Carlo calculations of dose-volume histograms for bone marrow in trabecular bone Phys. Med. Biol. 46 1149-61
21. Leggett R W 1992 A generic age-specific biokinetic model for calcium-like elements Radiat. Prot. Dosim. 41 183-98
22. Martin R B, Burr D B and Sharkey N A 1998 Skeletal Tissue Mechanics (New York: Springer)
23. 224Ra Health Effects of Internally Deposited Radionuclides: Emphasis on Radium, Thorium, Uranium and Their Daughter Products: Proc. HEIR 2004 ed U Oeh, P Roth and H G Paretzke (Neuherberg: GSF-Forschungszentrum) pp 67-74
24. Parfitt A M 1983 The physiologic and clinical significance of bone histomorphometric data Bone Histomorphology: Techniques and Interpretation ed R R Recker (Boca Raton, FL: CRC Press) pp 143-223
25. Priest N D 1990 The distribution and behaviour of heavy metals in the skeleton and body: studies with bone-seeking radionuclides Trace Metals and Fluoride in Bones and Teeth ed N D Priest and F L Van De Vyver (Boca Raton, FL: CRC Press) pp 83-139
26. Priest N D, Freemont A, Humphreys J A and Kathren R L 1995 Histopathology and 241 Am microdistribution in skeletal USTER Case 246 Health Phys 69 330-7
27. Priest N D and Giannola S J 1980 Uptake and loss of plutonium from osteoclasts and macrophages in the mandibular condyle of the rat Calcif. Tissue Int. 30 15-20
28. Richardson R B 2008 Age-dependent changes in oxygen tension, radiation dose and sensitivity within normal and diseased coronary arteries-part C. Oxygen effect and its implications on high- and low-LET dose Int. J. Radiat. Biol. 84 858-65
29. Richardson R B and Dunford D W 2003 A biochemical-based model for the dosimetry of dietary organically bound tritium-part 2. Physiological criteria Health Phys. 85 539-52
30. Richardson R B, Nie H L and Chettle D R 2007 Monte Carlo simulation of trabecular bone remodelling and absorbed dose coefficients for tritium and 14 C Radiat. Prot. Dosim. 127 158-62
31. Rozman C, Feliu E, Berga L, Reverter J C, Climent C and Ferran M J 1989 Age-related variations of fat tissue fraction in normal human bone marrow depend both on size and number of adipocytes: a stereological study Exp. Hematol. 17 34-7
32. Salmon P L, Onischuk Y N, Bondarenko O A and Lanyon L E 1999 Alpha-particle doses to cells of the bone remodeling cycle from alpha-particle-emitting bone-seekers: indications of an antiresorptive effect of actinides Radiat. Res. 152 S43-7
33. Schlenker R A, Keane A T and Unni K K 1989 Comparison of Radium-Induced and Natural Bone Sarcomas by Histological Type, Subject Age and Site of Occurrence British Institute of Radiology Report 21 (London: BIR) pp 55-63
34. 241Am at human bone surfaces: implications for the ICRP 30 bone dosimetry model Radiat. Prot. Dosim. 16 195-203
35. Shleien B 1992 The Health Physics and Radiological Health Handbook (Silver Spring, MD: Scinta)
36. Taichman R S 2005 Blood and bone: two tissues whose fates are intertwined to create the haematopoietic stem-cell niche Blood 105 2631-9
37. Thoday J M and Read J 1947 Effect of oxygen on the frequency of chromosomal aberrations produced by x-rays Nature 160 608-9
38. Unni K K 1996 Dahlin's Bone Tumours. General Aspects and Data on 11087 Cases 5th edn (Philadelphia, New York: Lippincott-Raven)
39. Watchman C J, Bourke V A, Lyon J R, Knowlton A E, Butler S L, Grier D D, Wingard J R, Braylan R C and Bolch W E 2007 Spatial distribution of blood vessels and CD34+ hematopoietic stem and progenitor cells within the marrow cavities of human cancellous bone J. Nucl. Med. 48 645-54
40. Woodard H Q and White D R 1986 The composition of body tissues Brit. J. Radiol. 59 1209-18