Inflammatory enteric neuropathy with severe constipation after ipilimumab treatment for melanoma: A case report

Journal of Immunotherapy

Volumn 32, Issue 2, 2009, Pages 203-205

  Bhatia, Shailender ^a,b   Huber, Bertrand R ^a   Upton, Melissa P ^a   Thompson, John A ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b SEATTLE CANCER CARE ALLIANCE   (United States)

Author keywords

Autoimmune neuritis; Autoimmunity; Constipation; CTLA 4; Inflammatory enteric neuropathy; Ipilimumab; MDX 010; Melanoma

Indexed keywords

BUDESONIDE; DOCUSATE SODIUM; FLEET ENEMA; IPILIMUMAB; LACTULOSE; MACROGOL; MONOCLONAL ANTIBODY;

ADULT; ARTICLE; AUTOPSY; B LYMPHOCYTE; CANCER IMMUNOTHERAPY; CANCER REGRESSION; CASE REPORT; CAUSE OF DEATH; COLON BIOPSY; CONSTIPATION; DISEASE EXACERBATION; DRUG DOSE ESCALATION; DRUG TREATMENT FAILURE; ENTEROPATHY; FIBER; HUMAN; HUMAN TISSUE; INFLAMMATORY ENTERIC NEUROPATHY; LYMPHOCYTIC INFILTRATION; MALE; MELANOMA; METASTASIS; MULTIPLE CYCLE TREATMENT; NERVOUS SYSTEM; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SIGMOIDOSCOPY; T LYMPHOCYTE; ENTEROCOLITIS; MIDDLE AGED; MYENTERIC PLEXUS; NEURITIS; PATHOLOGY; SKIN TUMOR;

ANTIBODIES, MONOCLONAL; CONSTIPATION; ENTEROCOLITIS; HUMANS; MALE; MELANOMA; MIDDLE AGED; MYENTERIC PLEXUS; NEURITIS; SKIN NEOPLASMS;

EID: 63649143542     PISSN: 15249557     EISSN: None     Source Type: Journal    
DOI: 10.1097/CJI.0b013e318193a206     Document Type: Article

References (8)

1. Beck KE, Blansfield JA, Tran KQ, et al. Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. J Clin Oncol. 2006;24:2283-2289.
2. Downey SG, Klapper JA, Smith FO, et al. Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade. Clin Cancer Res. 2007;13:6681-6688.
3. O'Mahony D, Morris JC, Quinn C, et al. A pilot study of CTLA-4 blockade after cancer vaccine failure in patients with advanced malignancy. Clin Cancer Res. 2007;13:958-964.
4. Small EJ, Tchekmedyian NS, Rini BI, et al. A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer. Clin Cancer Res. 2007; 13: 1810-1815.
5. Weber JS, Berman D, Siegel J, et al. Safety and efficacy of ipilimumab with or without prophylactic budesonide in treatment-naive and previously treated patients with advanced melanoma. J Clin Oncol. 2008;26(Suppl) abstract 9010.
6. De Giorgio R, Guerrini S, Barbara G, et al. Inflammatory neuropathies of the enteric nervous system. Gastroenterology. 2004;126:1872-1883.
7. Darnell RB, Posner JB. Paraneoplastic syndromes involving the nervous system. N Engl J Med. 2003;349:1543-1554.
8. Zhu J, Zou L, Zhu S, et al. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade enhances incidence and severity of experimental autoimmune neuritis in resistant mice. J Neuro-immunol. 2001;115:111-117.