Direct injection of Kit ligand-2 lentivirus improves cardiac repair and rescues mice post-myocardial infarction

Molecular Therapy

Volumn 17, Issue 2, 2009, Pages 262-268

  Higuchi, Koji ^a   Ayach, Bilal ^b,c,d   Sato, Takeya ^e   Chen, Manyin ^b   Devine, Sean P ^d   Rasaiah, Vanessa I ^a   Dawood, Fayez ^b   Yanagisawa, Teruyuki ^e   Tei, Chuwa ^f   Takenaka, Toshihiro ^f   Liu, Peter P ^b,c,d   Medin, Jeffrey A ^a,b,d  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 1; CARDIAC AGENT; CARDIOVASCULAR AGENT; CELL SURFACE ANTIGEN LY49; ENHANCED GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR; MEMBRANE ANTIGEN; STEM CELL FACTOR 1; STEM CELL FACTOR 2; STEM CELL FACTOR RECEPTOR; UNCLASSIFIED DRUG; GREEN FLUORESCENT PROTEIN; STEM CELL FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CARDIOVASCULAR GENE THERAPY; CONTROLLED STUDY; GENE EXPRESSION; HEART DISEASE; HEART INFARCTION; HEART LEFT VENTRICLE; HEART VOLUME; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; SURVIVAL; VIRAL GENE DELIVERY SYSTEM; WEIGHT REDUCTION; ANIMAL; CELL CULTURE; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE VECTOR; GENETICS; HEART MUSCLE; IMMUNOHISTOCHEMISTRY; INJECTION; LENTIVIRINAE; METABOLISM; METHODOLOGY; PATHOLOGY; PHYSIOLOGY;

ANIMALIA; LENTIVIRUS; MURINAE; MUS;

ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; IMMUNOHISTOCHEMISTRY; INJECTIONS; LENTIVIRUS; MICE; MYOCARDIAL INFARCTION; MYOCARDIUM; STEM CELL FACTOR;

EID: 63649139251     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2008.244     Document Type: Article

References (27)

1. Sasano, T, McDonald, AD, Kikuchi, K and Donahue, JK (2006). Molecular ablation of ventricular tachycardia after myocardial infarction. Nat Med 12: 1256-1258.
2. Kusano, KF, Pola, R, Murayama, T, Curry, C, Kawamoto, A, Iwakura, A et al. (2005). Sonic hedgehog myocardial gene therapy: Tissue repair through transient reconstitution of embryonic signaling. Nat Med 11: 1197-1204.
3. Higuchi, K and Medin, JA (2007). Lentiviral vectors for gene therapy of heart disease. J Cardiol 49: 1-11.
4. Takahashi, T, Kalka, C, Masuda, H, Chen, D, Silver, M, Kearney, M et al. (1999). Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med 5: 434-438.
5. Orlic, D, Kajstura, J, Chimenti, S, Limana, F, Jakoniuk, I, Quaini, F et al. (2001). Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci USA 98: 10344-10349.
6. Kawada, H, Fujita, J, Kinjo, K, Matsuzaki, Y, Tsuma, M, Miyatake, H et al. (2004). Nonhematopoietic mesenchymal stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction. Blood 104: 3581-3587.
7. Harada, M, Qin, Y, Takano, H, Minamino, T, Zou, Y, Toko, H et al. (2005). G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat Med 11 305-311.
8. Dawn, B, Guo, Y, Rezazadeh, A, Huang, Y, Stein, AB, Hunt, G et al. (2006). Postinfarct cytokine therapy regenerates cardiac tissue and improves left ventricular function. Circ Res 98: 1098-1105.
9. Woldbaek, PR, Hoen, IB, Christensen, G and Tonnessen, T (2002). Gene expression of colony-stimulating factors and stem cell factor after myocardial infarction in the mouse. Acta Physiol Scand 175: 173-181.
10. Ayach, BB, Yoshimitsu, M, Dawood, F, Sun, M, Arab, S, Chen, M et al. (2006). Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction. Proc Natl Acad Sci USA 103: 2304-2309.
11. Ashman, LK (1999). The biology of stem cell factor and its receptor C-kit. Int J Biochem Cell Biol 31: 1037-1051.
12. Miyazawa, K, Williams, DA, Gotoh, A, Nishimaki, J, Broxmeyer, HE and Toyama, K (1995). Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form. Blood 85: 641-649.
13. Caruana, G, Ashman, LK, Fujita, J and Gonda, TJ (1993). Responses of the murine myeloid cell line FDC-P1 to soluble and membrane-bound forms of steel factor (SLF). Exp Hematol 21: 761-768.
14. Caruana, G, Cambareri, AC and Ashman, LK (1999). Isoforms of c-KIT differ in activation of signaling pathways and transformation of NIH3T3 fibroblasts. Oncogene 18: 5573-5581.
15. Yoshimitsu, M, Higuchi, K, Dawood, F, Rasaiah, VI, Ayach, B, Chen, M et al. (2006). Correction of cardiac abnormalities in fabry mice by direct intraventricular injection of a recombinant lentiviral vector that engineers expression of alpha-galactosidase A. Circ J 70 1503-1508.
16. Yoshimitsu, M, Sato, T, Tao, K, Walia, JS, Rasaiah, VI, Sleep, GT et al. (2004). Bioluminescent imaging of a marking transgene and correction of Fabry mice by neonatal injection of recombinant lentiviral vectors. Proc Natl Acad Sci USA 101: 16909-16914.
17. Toksoz, D, Zsebo, KM, Smith, KA, Hu, S, Brankow, D, Suggs, SV et al. (1992). Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor. Proc Natl Acad Sci USA 89: 7350-7354.
18. Kitamura, T, Tange, T, Terasawa, T, Chiba, S, Kuwaki, T, Miyagawa, K et al. (1989). Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. J Cell Physiol 140: 323-334.
19. Naldini, L, Blomer, U, Gallay, P, Ory, D, Mulligan, R, Gage, FH et al. (1996). In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272: 263-267.
20. Naldini, L, Blomer, U, Gage, FH, Trono, D and Verma, IM (1996). Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci USA 93: 11382-11388.
21. Fleury, S, Simeoni, E, Zuppinger, C, Deglon, N, von Segesser, LK and Kappenberger, L et al. (2003). Multiply attenuated, self-inactivating lentiviral vectors efficiently deliver and express genes for extended periods of time in adult rat cardiomyocytes in vivo. Circulation 107: 2375-2382.
22. Orlic, D, Kajstura, J, Chimenti, S, Jakoniuk, I, Anderson, SM, Li, B et al. (2001). Bone marrow cells regenerate infarcted myocardium. Nature 410: 701-705.
23. Jackson, KA, Majka, SM, Wang, H, Pocius, J, Hartley, CJ, Majesky, MW et al. (2001). Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest 107: 1395-1402.
24. Linke, A, Muller, P, Nurzynska, D, Casarsa, C, Torella, D, Nascimbene, A et al. (2005). Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function. Proc Natl Acad Sci USA 102: 8966-8971.
25. Wang, Q, Sigmund, CD and Lin, JJ-C (2000). Identification of cis elements in the cardiac troponin T gene conferring specific expression in cardiac muscle of transgenic mice. Circ Res 86: 478-484.
26. Su, H, Joho, S, Huang, Y, Barcena, A, Arakawa-Hoyt, J, Grossman, W et al. (2004). Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts. Proc Natl Acad Sci USA 101: 16280-16285.
27. Sun, M, Dawood, F, Wen, WH, Chen, M, Dixon, I, Kirshenbaum, LA et al. (2004). Excessive tumor necrosis factor activation after infarction contributes to susceptibility of myocardial rupture and left ventricular dysfuction. Circulation 110: 3221-3228.