Allogeneic hematopoietic stem cell transplantation of patients with fa and high risk features using fludarabine without radiation

Pediatric Blood and Cancer

Volumn 52, Issue 5, 2009, Pages 683-685

  Baker, Jillian M ^a   Lewis, Victor A ^b   Fernandez, Conrad V ^c   Duval, Michel ^d   Crooks, Bruce N ^c   Yuille, Kim ^a   Freedman, Melvin H ^a   Doyle, John J ^a   Dror, Yigal ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b ALBERTA CHILDREN'S HOSPITAL   (Canada)

^c IWK HEALTH CENTRE   (Canada)

^d UNIVERSITY OF MONTREAL   (Canada)

Author keywords

FA; Fludarabine; Mairow failure; Reduced intensity; Transplantation

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN; CYTOMEGALOVIRUS ANTIBODY; FLUDARABINE; GANCICLOVIR; GRANULOCYTE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN; METHYLPREDNISOLONE; PREDNISONE; DRUG DERIVATIVE; VIDARABINE;

ADOLESCENT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FANCONI ANEMIA; FEBRILE NEUTROPENIA; FEMALE; GRAFT VERSUS HOST REACTION; HUMAN; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROPHYLAXIS; RISK FACTOR; SCHOOL CHILD; VIRUS INFECTION; ALLOTRANSPLANTATION; CLINICAL TRIAL; DRUG EFFECT; FOLLOW UP; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOSUPPRESSIVE TREATMENT; METHODOLOGY; MULTICENTER STUDY; PILOT STUDY; RADIATION; TREATMENT OUTCOME;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; FANCONI ANEMIA; FEMALE; FOLLOW-UP STUDIES; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; PILOT PROJECTS; RADIATION; RISK FACTORS; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME; VIDARABINE;

EID: 63649093212     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.21921     Document Type: Article

References (20)

1. Gluckman E, Auerbach AD, Horowitz MM, et al. Bone marrow transplantation for FA. Blood 1995;86:2856-2862.
2. Kutler DI, Singh B, Satagopan J, et al. A 20-year perspective on the International FA Registry (IFAR). Blood 2003;101:1249-1256.
3. Dokal I. Dyskeratosis congenita in all its forms. Br J Haematol 2000;110:768-779.
4. Alter B. Nathan and Oski's hematology of infancy and childhood, 6th edition. Philadelphia: W.B: Saunders Co 2005; p. 289.
5. Gluckman E, Devergie A, Dutreix J. Radiosensitivity in Fanconi anaemia: application to the conditioning regimen for bone marrow transplantation. Br J Haematol 1983;54:431-440.
6. MacMillan ML, Auerbach AD, Davies SM, et al. Haematopoietic cell transplantation in patients with Fanconi anaemia using alternate donors: Results of a total body irradiation dose escalation trial. Br J Haematol 2000;109:121-129.
7. Davies SM, Khan S, Wagner JE, et al. Unrelated donor bone marrow transplantation for FA. Bone Marrow Transplant 1996;17: 43-47.
8. Guardiola P, Pasquini R, Dokal I, et al. Outcome of 69 allogeneic stem cell transplantations for FA using HLA-matched unrelated donors: A study on behalf of the European Group for Blood and Marrow Transplantation. Blood 2000;95:422-429.
9. Socie G, Devergie A, Girinski T, et al. Transplantation for Fanconi's anaemia: long-term follow-up of fifty patients transplanted from a sibling donor after low-dose cyclophosphamide and thoraco-abdominal irradiation for conditioning. Br J Haematol 1998;103:249-255.
10. Boulad F, Auerbach AD, Kernan NA, et al. Fludarabine based cytoreductive regimen and T-cell depleted grafts from unrelated or mismatched donors for the treatment of high risk patients with FA (FA). Blood 2004;104:592a.
11. Boulad F, Gillio A, Small TN, et al. Stem cell transplantation for the treatment of Fanconi anaemia using a fludarabine-based cytor- eductive regimen and T-cell-depleted related HLA-mismatched peripheral blood stem cell grafts. Br J Haematol 2000;111:1153-1157.
12. Kapelushnik J, Or R, Slavin S, et al. A fludarabine-based protocol for bone marrow transplantation in Fanconi's anemia. Bone Marrow Transplant 1997;20:1109-1110.
13. Tan PL, Wagner JE, Auerbach AD, et al. Successful engraftment without radiation after fludarabine-based regimen in Fanconi Anemia patients undergoing genotypically identical donor hema- topoietic cell transplantation. Pediatr Blood Cancer 2006;46:630-636.
14. McCloy M, Almeida A, Daly P, et al. Fludarabine-based stem cell transplantation protocol for Fanconi's anaemia in myelodysplastic transformation. Br J Haematol 2001;112:427-429.
15. Wagner JE, Eapen M, MacMillan ML, et al. Unrelated donor bone marrow transplantation for the treatment of FA. Blood 2007; 109:2256-2262.
16. Tan P-L, Wagner JE, Auerbach AD, et al. Successful engraftment without radiation after fludarabine-based regiment in FA patients undergoing genotypically identical donor hematopoietic cell transplantation. Pediatr Blood Cancer 2006;46:630-636.
17. Aker M, Varadi G, Slavin S, et al. Fludarabine-based protocol for human umbilical cord blood transplantation in children with FA. J Pediatr Hematol Oncol 1999;21:237-239.
18. de la Fuente J, Reiss S, McCloy M, et al. Non-TBI stem cell transplantation protocol for Fanconi anaemia using HLA-compat- ible sibling and unrelated donors. Bone Marrow Transplant 2003;32:653-656.
19. Motwani J, Lawson SE, Darbyshire PJ. Successful HSCT using nonradiotherapy-based conditioning regimens and alternative donors in patients with Fanconi anaemiaExperience in a single UK centre. Bone Marrow Transplant 2005;36:405 -410.
20. Petersdorf EW, Longton GM, Anasetti C, et al. Association of HLA-C disparity with graft failure after marrow transplantation from unrelated donors. Blood 1997;89:1818-1823.